This means that animal welfare can now, for the first time, be properly considered alongside other impacts of farming to help identify which farming systems are best.

This is vital for improving animal welfare in livestock production, at a time when demand for meat is rising globally and the way animals are farmed is changing - with concerns about the welfare of intensive and indoor systems.

Animal welfare assessments could also enable consumers to be better informed when choosing what to eat.

Britain has various labelling schemes for meat products to assure consumers that certain standards have been met. The team used their new system to test how the different labels compare in terms of animal welfare.

Farms producing ‘woodland’ labelled pork products scored best for pig welfare, followed by ‘organic’, then free-range, RSPCA assured, Red Tractor, and finally those with no certification.

“We have shown that it’s possible to reliably assess animal welfare on farms. This means decisions about which types of farm are better or worse for animal welfare can be based on proper calculations, rather than assumptions – as is currently the case,” said Dr Harriet Bartlett, first author of the study, who carried out this work while a researcher at the University of Cambridge’s Department of Veterinary Medicine. She is now a Research Associate in Sustainable Food Solutions at the University of Oxford.

Bartlett added: “Now animal welfare can be included in overall assessments of farm sustainability alongside other measures like carbon emissions and biodiversity impacts, so we can make better informed decisions about how we choose to farm and what we choose to eat.”

Coming up with an overall measurement of animal welfare has previously been difficult because of disagreement on which factors are most important. For example, is a health problem more important than a behaviour problem? What level of welfare is good enough?

The new system assesses the quality of an animal’s life through a wide-ranging set of welfare measurements, reflecting a range of concerns about welfare. The results can be integrated into a single score to enable comparison across farms.

This will enable exploration of trade-offs between animal welfare and other issues of concern to consumers, such as the impact of farming on the environment.

The results are published today in the journal Proceedings of the Royal Society B.

Assessment of the pigs looked at everything from health problems like coughing, sneezing, and lameness, to the way they interacted: biting each other’s ears or tails, or engaging with their environment, for example.

Various scoring methods were tested - giving more or less weight to the different aspects of animal welfare - on 74 pig farming systems in the UK. The team were surprised to find that each method gave broadly the same overall result in terms of which farms, and types of farms, performed best and worst.

“Despite ongoing debate about how to measure animal welfare, we found we can identify which types of farms we might want to encourage and which we shouldn’t with reasonable consistency,” said Professor Andrew Balmford in the University of Cambridge’s Department of Zoology, who was involved in the study.

The new welfare measurements combine quality of life with length of life, and scores can be produced ‘per unit’ of production. The welfare scores can also allow several farms to be grouped together – for example when animals are kept on different farms at different growth stages.

“This work opens up possibilities for greater rolling out of welfare assessment scores in food labelling, including in other species as well as pigs. Until now, the methods available have made this impractical,” said Professor James Wood at the University of Cambridge’s Department of Veterinary Medicine, who was involved in the study.

The technique of ‘Life Cycle Assessment’ is widely used to quantify environmental impacts, such as greenhouse gas emissions and land use, across all stages of farm animal production. But until now there hasn’t been a way of measuring animal welfare that enables valid comparisons across different farming systems, so Life Cycle Assessments do not include it and as a result, welfare concerns have sometimes been overlooked.

Food production accounts for over a quarter of all global greenhouse gas emissions. Making farming systems more sustainable, in the face of growing global demand for meat, is a major challenge for farmers and the government.

‘Woodland’ labelled pork is from farms that provide at least partial tree cover for the pigs, and ‘Organic’ provides outdoor access for the animals. The ‘RSPCA assured’ label is welfare focused, while ‘Free range’ is not a formal assurance, but typically refers to fully outdoor farming systems. Most UK pig farms produce ‘Red Tractor’ labelled pork, which has lower production costs – translating to a lower price for consumers.

This research was funded by the BBSRC, the Royal Society, MRC, and The Alborada Trust.

Reference

Bartlett, H. et al: ‘Advancing the quantitative characterisation of farm animal welfare.’ Proc Roy Soc B. March 2023. DOI 10.1098/rspb.2023.0120

A study has found that infrastructure worldwide is widespread in sites that have been identified as internationally important for biodiversity, and its prevalence is likely to increase.

This is the first ever assessment of the presence of infrastructure in Key Biodiversity Areas (KBAs): a global network of thousands of sites recognised internationally as being the world’s most critical areas for wildlife.

Infrastructure is one of the greatest drivers of threats to biodiversity according to the International Union for Conservation of Nature. It can cause natural habitat destruction and fragmentation, pollution, increased disturbance or hunting by humans, the spread of invasive species, direct mortality, and can have wider impacts beyond the development site.

Now, researchers from BirdLife International, WWF and the RSPB, in association with the University of Cambridge, have conducted an assessment of infrastructure in KBAs, finding that it is widespread and likely to increase. The results are published today in Biological Conservation.

“It’s concerning that human developments exist in the vast majority of sites that have been identified as being critical for nature,” said Ash Simkins, a Zoology PhD student at the University of Cambridge who led the study.

KBAs are sites that contribute significantly to the global persistence of biodiversity. For example, they may contain species that are under a high risk of extinction or are home to species or ecosystems that are found in only a small area worldwide.

Researchers assessed 15,150 KBAs on land and found that 80% contained infrastructure. Multiple combinations of infrastructure types occurred in KBAs with the most common being roads (75%), power lines (37%) and urban areas (37%).

They found that potential future planned infrastructure developments could lead to an additional 2,201 KBAs containing mines (from 754 to 2,955; 292% increase), an additional 1,508 KBAs containing oil and gas infrastructure (from 2,081 to 3,589; 72% increase) and an additional 1,372 KBAs containing power plants (from 233 to 1,605; 589% increase).

Maps of KBAs were intersected with spatial datasets of different types of infrastructure that researchers categorised as transport, dams and reservoirs, extractives (relating to natural resources), energy (power lines and power plants) and urban areas.

Energy and extractives were the only categories for which some global data on potential future planned developments was available.

“We recognise that infrastructure is essential to human development but it’s about building smartly. This means ideally avoiding or otherwise minimising infrastructure in the most important locations for biodiversity. If the infrastructure must be there, then it should be designed to cause as little damage as possible, and the impacts more than compensated for elsewhere,” said Simkins.

Researchers found that countries in South America, (for example 82% of KBAs in Brazil), Sub-Saharan, Central and Southern Africa, and parts of South-east Asia are amongst the areas with the highest proportion of extractive claims, concessions or planned development in their KBA networks. All of the KBAs identified to date in Bangladesh, Kuwait, the Republic of the Congo and Serbia have potential extractive claims, concessions or planned development.

“It’s also concerning to see that in the future, extensive mining and oil and gas related infrastructure is planned to be built in many of the world’s most important sites for biodiversity,” said Simkins.

Some of the technology to tackle the climate crisis, like solar panels and wind turbines, is also dependent on mining for precious metals. “We need smart solutions to the climate crisis whilst avoiding or minimising negative impacts on biodiversity,” said Simkins.

“At the UN biodiversity COP15 meetings in Montreal last year, governments committed to halting human-induced extinctions,” said co-author Dr Stuart Butchart, Chief Scientist at BirdLife International and Honorary Research Fellow at Cambridge’s Department of Zoology. “Widespread destruction or degradation of the natural habitats within KBAs could lead to wholesale extinctions, so existing infrastructure in KBAs must be managed to minimise impacts, and further development in these sites has to be avoided as far as possible.”

“Infrastructure underpins our societies, delivering the water we drink, the roads we travel on, and the electricity that powers livelihoods,” said Wendy Elliott, Deputy Leader for Wildlife at WWF. “This study illustrates the crucial importance of ensuring smart infrastructure development that provides social and economic value for all, whilst ensuring positive outcomes for nature. Making this happen will be the challenge of our time, but with the right planning, design and commitment it is well within the realms of possibility.”

Researchers say that infrastructure within a KBA varies in the degree to which it may drive a loss of biodiversity. More research is required to find out the extent to which infrastructure in a particular KBA affects wildlife within the site and what measures are needed to mitigate this.

Reference: A.T Simkins et al, A global assessment of the prevalence of current and potential future infrastructure in Key Biodiversity Areas, Biological Conservation, DOI: 10.1016/j.biocon.2023.109953

The Victor Phillip Dahdaleh Heart and Lung Research Institute (HLRI) is home to the largest concentration of scientists and clinicians in heart and lung medicine in Europe. It opened in July 2022 with the ambitious goal of identifying ten new potential treatments or diagnostic tests for heart and lung diseases within five years.

The HLRI is located on Cambridge’s rapidly expanding Biomedical Campus, immediately adjacent to Royal Papworth Hospital. The institute brings together population health, laboratory and clinical scientists, with NHS clinicians and patients, with the aim of improving outcomes for people with cardiovascular and lung diseases such as heart attacks, pulmonary hypertension, lung cancers, cystic fibrosis and acute respiratory distress syndrome.

Dr Dahdaleh said: “Cambridge is one of the greatest Universities in the history of civilisation and, 800 years on, it is at the cutting edge of scientific progress. Over the years in which I have been supporting education and medical research around the world, I have realised the UK is a global leader in the prevention, identification and treatment of heart and lung diseases.

“I’m supporting this new Institute because, through collaboration with Royal Papworth Hospital and other leading institutions, it will enable a concentration of expertise that will make medical advances in these fields that are of international importance.”

Dr Dahdaleh has previously supported research at the University of Cambridge looking into COVID-19 and national research on mesothelioma, a type of lung cancer linked to asbestos exposure. Cardiovascular and lung diseases kill more than 26 million people a year and have a major impact on the quality of life of many more. Alongside the immense human cost, the economic burden of these diseases – an estimated annual global cost of £840 billion – is already overwhelming and unsustainable. Yet declining air quality and increasing rates of obesity are set to compound the scale of the challenge faced worldwide.

Dr Anthony Freeling, Acting Vice-Chancellor of the University of Cambridge, said: “We are truly grateful to Victor for his generous donation. There has never been a more pressing need to develop new approaches and treatments to help us tackle the heart and lung diseases that affect many millions of people worldwide. The Victor Phillip Dahdaleh Heart and Lung Research Institute is in a strong position to make a major difference to people’s lives.”

Professor John Wallwork, Chair of Royal Papworth Hospital NHS Foundation Trust, said: “When we moved our hospital to the Cambridge Biomedical Campus in 2019, one of our ambitions was to collaborate with partners to create a research and education institute on this scale. Victor’s kind donation will support all the teams working in HLRI to develop new treatments in cardiovascular and respiratory diseases, improving the lives of people in the UK and around the globe.”

The HLRI includes state-of-the-art research facilities, space for collaboration between academia, healthcare providers and industry, conference and education facilities. It also includes a special 10-bed clinical research facility where the first-in-patient studies of new treatments are being conducted.

Professor Charlotte Summers, Interim Director of the HLRI, said: “We have set ourselves ambitious goals because of the urgent need to improve cardiovascular and lung health across the world. Victor’s generous gift will help us realise our ambitions. Collaboration is at the heart of our approach, with our researchers and clinicians working with patient, academic, charity and industry partners within the Cambridge Cluster, nationally and internationally.”

Dr Dahdaleh is also a significant supporter of the Duke of Edinburgh awards, York and McGill universities in his homeland of Canada, and the British Lung Foundation. Dr Dahdaleh and his wife Mona, via the Victor Dahdaleh Foundation, have a commitment to supporting scholarships for disadvantaged students pursuing higher education in addition to their extensive philanthropic support for research into cancer, lung and heart disease.

The HLRI has already raised £30 million from the UK Research Partnership Investment Fund and £10 million from the British Heart Foundation, with additional funding from the Wolfson Foundation, Royal Papworth Hospital Charity and the University of Cambridge. Additional support has been provided by the Cystic Fibrosis Trust for a Cystic Fibrosis Trust Innovation Hub within the institute.

Read more: "There isn’t anything like it in the UK" - The new institute tackling some of the world's biggest killers

The Lundbeck Foundation has announced today the recipients of The Brain Prize 2023, the world’s largest award for outstanding contributions to neuroscience.

Professor Christine Holt shares the award with two other neuroscientists, Professor Erin Schuman at the Max Planck Institute for Brain Research, and Professor Michael Greenberg at Harvard Medical School.

A profound aspect of our nervous system is that during development and adulthood our brains are subject to extensive change, known as neural plasticity. Collectively, the scientists have made significant advances in unveiling the cellular and molecular mechanisms that enable the brain to develop, and to restructure itself in response to external stimuli as it adapts, learns, and even recovers from injury.

“Receiving the Brain Prize is an honour beyond my wildest dreams, and I’m absolutely delighted. It’s an incredible recognition of the work that we have been doing over the last forty years,” said Christine Holt, Professor of Developmental Neuroscience in the Department of Physiology, Development and Neuroscience at the University of Cambridge.

The Brain Prize, which is considered the world’s most significant prize for brain research, includes approximately €1.3 million to be shared by the three recipients. The prize is awarded annually by the Danish Lundbeck Foundation to researchers who have made highly original and influential discoveries in brain research.

“Our work has revealed the surprisingly fast and precise mechanism by which brains ‘wire-up’ during development, and actively maintain their wiring throughout life,” said Holt.

She added: “This provides key insights into the causes of neurodevelopmental and neurodegenerative diseases. Fundamental knowledge of this sort is essential for developing clinical therapies in nerve repair.”

The brain is an extraordinarily complex organ made up of billions of individual cells - called neurons - that are wired together in very precise ways. This organisation underlies our ability to sense and interact with the outside world.

If the brain wiring connections fail to form, or form incorrectly, then serious neurological deficits may result - such as blindness. Similarly, if the connections fail to be maintained, as occurs in many neurodegenerative diseases - such as dementia - then important neurological function may be lost.

Holt’s work on the developing brain revealed that each neuron sends out a long ‘wire’ - called an axon - that navigates a remarkable journey to its own specific target in the brain. When an axon first grows out from a neuron it is tipped with a specialised growth cone, which finds its way using guidance cues - much like reading signposts along a road.

Holt found that an important aspect of this navigation system is the autonomy of growth cones in reading and responding to guidance cues. The growth cone contains all the machinery necessary to make the new proteins the axons need to steer along the right pathway. She also found that proteins are continuously made in our axons every day – an important process enabling the developing and adult brain to be shaped by experience.

Other laboratories around the world are now looking at how mutations in these proteins affect the growth and survival of axons. The hope is that new therapies can be developed for treating neurodevelopmental and neurodegenerative diseases.

“It is such a great honour to share the prize with Erin Schuman and Mike Greenberg. Their beautiful work has been an inspiration to me over the years. It’s been an exciting journey of discovery that may eventually lead to advances in therapies for neurodegenerative disease and neural repair. Thank you most sincerely to the Lundbeck Foundation,’’ said Holt.

‘‘In order to establish appropriate neural connections during development or to adapt to new challenges in adulthood through learning and memory, brain circuits must be remodeled, and the new patterns of connectivity maintained; processes that require the synthesis of new proteins for those connections,” said Professor Richard Morris, Chair of The Brain Prize Selection Committee.

He added: “The Brain Prize winners of 2023, Michael Greenberg, Christine Holt, and Erin Schuman have revealed the fundamental principles of how this enigmatic feature of brain function is mediated at the molecular level. Together, they have made ground-breaking discoveries by showing how the synthesis of new proteins is triggered in different neuronal compartments, thereby guiding brain development and plasticity in ways that impact our behavior for a lifetime.’’

The Brain Prize is the world’s largest neuroscience research prize, awarded each year by the Lundbeck Foundation. The Brain Prize recognises highly original and influential advances in any area of brain research, from basic neuroscience to applied clinical research. Recipients of The Brain Prize may be of any nationality and work in any country in the world. Since it was first awarded in 2011 The Brain Prize has been awarded to 44 scientists from 9 different countries.

Brain Prize recipients are presented with their award by His Royal Highness, The Crown Prince of Denmark, at a ceremony in the Danish capital, Copenhagen.

The UK Innovation Report 2023, compiled by Cambridge Industrial Innovation Policy - based at the University's Institute for Manufacturing - brings together innovation and value-added indicators in a single resource.

Among other analyses, the report looks at whether the UK is producing enough scientists and engineers, and how innovation translates into internationally competitive industries and well-paid jobs.

It also provides deep dives into the food and drinks, and aerospace sectors, offering insights into the structure and performance of these UK industries.

Last year's edition reported a new Innovation Strategy, a new Office for Science and Technology Strategy and a new National Science and Technology Council. This year, the major institutional change has been the ministerial restructure in February 2023. A new Department for Science, Innovation and Technology (DSIT) was created with the mandate to ensure the UK is “the most innovative economy in the world” and a “science and technology superpower”. 

Co-author Dr Carlos López-Gómez, from Cambridge Industrial Innovation Policy, said: "What the report does differently is to bring together multiple different sources of data on innovation – which are often only accessible to specialised audiences and challenging to navigate – in one centralised place.

"By curating these insights, the report provides an honest assessment of UK performance compared with key competitors. It’s designed to provide policymakers with the evidence needed to best promote innovation in industry.

"The report tries to bring attention to the interplay between these innovation inputs and the outcomes from an industrial perspective. This is because the value of our investment in science and technology can only be fully captured if it sustains a competitive and sustainable industry – one that provides well-paid jobs and helps address regional imbalances."

The discovery is a step towards harnessing the protective effects of cooling the brain to treat patients with acute brain injury and even to prevent dementias, such as Alzheimer’s.

When the body cools down significantly, it increases its levels of RBM3, a molecule known as the cold shock protein – a phenomenon first observed in hibernating animals. It is thought that during hibernation, the protein helps protect the brain from damage and allows it to continue to form new connections.

In 2015, Professor Giovanna Mallucci and colleagues showed in mice that RBM3 can protect the brain against damage associated with build-up of misfolded proteins, which can lead to various forms of dementia, such as Alzheimer’s and Parkinson’s disease, and from prion diseases such as Creutzfeldt-Jakob Disease (CJD).

Induced hypothermia is used to treat patients in intensive care units – including newborn babies and traumatic brain injury patients – with the patients placed into a coma and their brains cooled to protect against damage. But this comes with associated risks, such as blood clotting and pneumonia. Could the cold shock protein be harnessed to treat patients without having to cool the body, offering a safer treatment for acute brain injury or a way of protecting the brain against dementia?

In research published in EMBO Molecular Medicine, scientists at the UK Dementia Research Institute, University of Cambridge, and the Institute of Chemistry and Biochemistry, Freie Universität Berlin, studied whether a form of gene therapy known as antisense oligonucleotides (ASOs) could increase levels of the cold shock protein in the brains of mice – and hence protect them.

The team examined the gene that codes for production of the cold shock protein and found that it contains a key element which under normal conditions prevents its expression.  Removing, or ‘dialling down’ this element using an ASO, results in a long-lasting boost to production of RBM3.

To test whether this approach could protect the brain, the researchers used mice infected with prions.  Some of these mice were injected with a single dose of the ASO three weeks later, while the others were given a control treatment.

Twelve weeks after being administered the prions, those mice that had received the control treatment succumbed to prion disease and showed extensive loss of neurons in the hippocampus, an area of the brain important for memory.

The story was very different for the mice that had received the ASO. At the same time as the other mice were succumbing to prion disease, the ASO-treated mice had levels of RBM3 twice as high as in the other mice. Seven of the eight ASO-treated mice showed extensive preservation of neurons in the hippocampus.

Professor Giovanna Mallucci, who led the work while at the UK Dementia Research Institute at the University of Cambridge, said: “Essentially, the cold shock protein enables the brain to protect itself – in this case, against the damage to nerve cells in the brain during prion disease. Remarkably, we showed that just a single injection with the ASO was sufficient to provide long-lasting protection for these mice, preventing the inevitable progression of neurodegeneration.”

Professor Florian Heyd from Freie Universität Berlin added: “This approach offers the prospect of being able to protect against diseases such as Alzheimer’s and Parkinson’s disease, for which we have no reliable preventative treatments.

“We are still a long way off this stage as our work was in mice, but if we can safely use ASOs to boost production of the cold shock protein in humans, it might be possible to prevent dementia. We are already seeing ASOs being used to successfully treat spinal muscular atrophy and they have recently been licenced to treat motor neurone disease.”

If the findings can be replicated in humans, this approach could have major implications for the treatment of patients beyond neurodegeneration.  These include acute brain injury from newborn babies with hypoxia through protecting the brain in heart surgery, stroke and head injury in adults who would otherwise be treated by therapeutic hypothermia.

Professor Mallucci is now based at the Alto Labs, Cambridge Institute of Science.

The research was supported by core funding from the Freie Universität Berlin and by the UK Dementia Research Institute, which in turn is funded by the Medical Research Council, Alzheimer’s Society and Alzheimer’s Research UK.

Reference
Preußner, M et al. ASO targeting temperature-controlled RBM3 poison exon splicing prevents neurodegeneration in vivo. EMBO Molecular Medicine; 22 March 2023; DOI: 10.15252/emmm.202217157

Funded by The Brain Tumour Charity, this research aims to develop new ways to diagnose medulloblastoma using minimally invasive methods, protecting the quality of life of children with this diagnosis.

Medulloblastoma is the most common cancerous childhood brain tumours, accounting for 15-20% of all childhood brain tumour diagnoses. Around 52 children are diagnosed with a medulloblastoma each year in the UK. These tumours are fast growing and develop at the back of the brain in the cerebellum.

Dr Jessica Taylor, a postdoctoral researcher at the University of Cambridge working in Professor Richard Gilbertson’s lab at the Cancer Research UK Cambridge Institute, will focus on one of the four subtypes of medulloblastoma - wingless (WNT) medulloblastoma. WNT-medulloblastoma is typically difficult to operate on, but is highly curable with chemotherapy and radiation.

The research will use antibodies that have been designed to bind to the WNT-medulloblastoma cells. Once bound to the cells, they will be visible on a PET scan and can be used to diagnose this subtype of medulloblastoma. This method avoids the use of invasive surgery and so will protect children from the potential long-term, damaging effects of surgery such as memory problems and speech issues.

Dr Taylor, the recipient of a Future Leaders Award from The Brain Tumour Charity, said: “With one in four children with this tumour type suffering long-term memory loss and speech issues after surgery, it is important that we work towards improving diagnostic methods which avoid surgery.

“I hope my research will change the way medulloblastoma is clinically diagnosed and that it will improve the treatment and quality of life for children diagnosed with this disease.”

The antibodies will be designed to bind to drugs that could treat WNT-medulloblastoma. This innovative approach would deliver treatments directly to the tumour, potentially replacing the need for more traditional chemotherapy. This could have several benefits including giving patients an additional treatment option and offering a more targeted therapy, potentially reducing the side effects from treatment.

Dr David Jenkinson, Chief Scientific Officer at The Brain Tumour Charity, said: “This innovative project exploits the features of WNT-medulloblastoma to create specific antibodies that will help diagnose and even treat this type of tumour, avoiding unnecessary surgery for the children diagnosed. Focusing research on non-invasive diagnostics and treatments helps to prevent long-term damage that can result from surgery.”

Adapted from a press release from The Brain Tumour Charity

It was an exceptional weekend of sport between Cambridge and Oxford University which saw Cambridge win five out of six sporting fixtures. The Light Blues won the 141st men’s Varsity Rugby Match on Saturday, followed by The Boat Race on Sunday where Cambridge won the 77th Women’s Race, the 168th Men’s Race and both Reserve races.

Cambridge University RUFC men’s team dug deep at Twickenham on Saturday 25 March to deny Oxford a hat-trick of victories. The Cambridge Light Blues, led by Jamie Benson, took the match 15-10 to extend the winning head-to-head record in the fixture to 65-62.

The following day, The Boat Race was dominated by Cambridge, who comprehensively won all four races along The Championship Course on the River Thames, London.

The Cambridge Women’s crew took victory by four-and-a-quarter lengths, making it a sixth straight win for the women's team.

The men’s crew held off a late charge from Oxford to win by just over a length for their fourth victory in the past five races.

Cambridge lead the rivalry 47-30 in the women's event, while Cambridge men have won 86 times to Oxford's 81.

Cambridge University RUFC women’s were defeated in the Varsity Rugby Match for the first time since 2016 with a 31-12 loss against their Oxford counterparts at Twickenham. They had racked up wins in 2017, 2018 and 2019 before last year’s meeting between the rivals ended in a first ever draw, meaning Cambridge successfully defended the title.
 

Researchers from the University of Cambridge, the Wellcome Sanger Institute, the Friedrich Miescher Institute for Biomedical Research (FMI), Switzerland, EMBL’s European Bioinformatics Institute (EMBL-EBI), and collaborators, have created an in-depth picture of how the placenta develops and communicates with the uterus.

The study, published today in the journal Nature, is part of the Human Cell Atlas initiative to map every cell type in the human body. It informs and enables the development of experimental models of the human placenta.

"For the first time, we have been able to draw the full picture of how the placenta develops and describe in detail the cells involved in each of the crucial steps. This new level of insight can help us improve laboratory models to continue investigating pregnancy disorders, which cause illness and death worldwide,” said Anna Arutyunyan, co-first author at the University of Cambridge and Wellcome Sanger Institute.

The placenta is a temporary organ built by the foetus that facilitates vital functions such as foetal nutrition, oxygen and gas exchange, and protects against infections.The formation and embedding of the placenta into the uterus, known as placentation, is crucial for a successful pregnancy.

Understanding normal and disordered placentation at a molecular level can help answer questions about poorly understood disorders including miscarriage, stillbirth, and pre-eclampsia. In the UK, mild pre-eclampsia affects up to six per cent of pregnancies. Severe cases are rarer, developing in about one to two per cent of pregnancies.

Many of the processes in pregnancy are not fully understood, despite pregnancy disorders causing illness and death worldwide. This is partly due to the process of placentation being difficult to study in humans, and while animal studies are useful, they have limitations due to physiological differences.

During its development, the placenta forms tree-like structures that attach to the uterus, and the outer layer of cells, called trophoblast, migrate through the uterine wall, transforming the maternal blood vessels to establish a supply line for oxygen and nutrients.  

In the new study, scientists built on previous work investigating the early stages of pregnancy, to capture the process of placental development in unprecedented detail. Cutting-edge genomic techniques allowed them to see all of the cell types involved and how trophoblast cells communicate with the maternal uterine environment around them.

The team uncovered the full trajectory of trophoblast development, suggesting what could go wrong in disease and describing the involvement of multiple populations of cells, such as maternal immune and vascular cells.

"This research is unique as it was possible to use rare historical samples that encompassed all the stages of placentation occurring deep inside the uterus. We are glad to have created this open-access cell atlas to ensure that the scientific community can use our research to inform future studies,” said Professor Ashley Moffett, co-senior author at the University of Cambridge's Department of Pathology.

They also compared these results to placental trophoblast organoids, sometimes called ‘mini-placentas’, that are grown in the lab. They found that most of the cells identified in the tissue samples can be seen in these organoid models. Some later populations of trophoblast are not seen and are likely to form in the uterus only after receiving signals from maternal cells.   

The team focussed on the role of one understudied population of maternal immune cells known as macrophages. They also discovered that other maternal uterine cells release communication signals that regulate placental growth.

The insights from this research can start to piece together the unknowns about this stage of pregnancy. The new understanding will help in the development of effective lab models to study placental development and facilitate new ways to diagnose, prevent, and treat pregnancy disorders.

This research was funded by Wellcome, The Royal Society, and the European Research Council.

Reference

Arutyunyan, A. et al: 'Spatial multiomics map of trophoblast development in early pregnancy.' March 2023, Nature. DOI: 10.1038/s41586-023-05869-0

Adapted from a press release by the Wellcome Sanger Institute.

The team used a simulated supermarket that presented shoppers with varying proportions of alcoholic and non-alcoholic drinks and asked them to select drinks to purchase for their next online shop. They found that shoppers who were exposed to more non-alcoholic drinks selected and purchased fewer units of alcohol. The findings are published in PLOS Medicine.

Excessive alcohol consumption is a major risk factor for a number of diseases, including cancer, heart disease and stroke. Encouraging people to change their behaviour could therefore have significant health benefits at both an individual and population level.

There is increasing evidence that people can be ‘nudged’ towards reducing their alcohol consumption by making small adjustments to their environment. For example, scientists at Cambridge’s Behaviour and Health Research Unit have previously shown that serving wine in smaller glasses – even while keeping the amount of wine in the glasses the same – led to people consuming less alcohol.

A recent analysis found that reducing the proportion of unhealthy snacks available can reduce how much of these food products people consume, though the evidence included was limited in both quality and quantity. The Cambridge team wanted to see if a similar approach might work to nudge people towards consuming fewer alcoholic drinks.

The researchers recruited 737 adults living in England and Wales, all of whom regularly purchased alcohol online, to take part in the study. Of these, just over 600 completed the study and were included in the final analysis – 60% were female and the average (mean) age was 38.

Participants selected drinks from 64 options in a simulated online supermarket designed to look and function like a real online supermarket. Options included a range of beers, ciders, alcohol-free beer and cider alternatives, and soft drinks.

Participants were randomly assigned to one of three groups, each of which was presented with a different proportion of alcoholic and non-alcoholic drinks. 25% of the drinks seen by Group 1 were non-alcoholic. For Group 2, this increased to 50%, and for Group 3 the proportion of non-alcoholic drinks seen rose to 75%.

Those exposed to the highest proportion of non-alcoholic drinks (Group 3) selected fewer alcohol units, 17.5 units, compared to 29.4 units in those exposed to the lowest proportion of non-alcoholic drinks (Group 1) – equivalent to a reduction of about 41%.

Participants were then asked to actually purchase the same drinks in an online supermarket, Tesco, the largest national supermarket in the UK. Around two-thirds of participants completed this second stage, with 422 participants going on to purchase drinks. The researchers point out that ‘cart abandonment’ – where people do not purchase items they put in their shopping cart – is common in online shopping contexts.

The researchers found that amongst participants exposed to the highest proportion of non-alcoholic drinks, 52% of the drinks purchased were alcoholic, compared to 70% of drinks that were purchased by those exposed to the lowest proportion of non-alcoholic drinks.

Lead author Dr Natasha Clarke said: “We created our simulated supermarket to be as close as possible to an actual online supermarket and found that increasing the proportion of non-alcoholic drinks that shoppers were exposed to made a meaningful difference to their alcohol selection. Though we’d need to confirm these findings using only a real online supermarket, they are very promising.”

While the current market for alcohol-free beer, wine and spirits represents only a small share of the global alcohol industry, it is rapidly growing. For example, low and no-alcohol beer currently accounts for 3% of the total beer market, but this is forecast to increase by nearly 13% per year over the next 3 years and is the fastest growing drinks segment in the UK.

Senior author Dr Gareth Hollands said: “Supermarkets typically stock a wider range of alcoholic drinks than non-alcoholic alternatives aimed at adults, but this is slowly changing. Our results suggest that if non-alcoholic options were to become the majority instead, we might expect to see substantial reductions in alcohol purchasing.”

Importantly, the overall number of drinks that participants selected and purchased remained similar between groups, suggesting that effects were a result of shifting people’s choices. This implies overall drink sales and potentially revenues may be relatively unchanged, dependent on the pricing of non-alcoholic drinks.

Professor Dame Theresa Marteau, Director of the Behaviour and Health Research Unit and a Bye-Fellow at Christ's College, said: “We all know that drinking too much alcohol is bad for us, but we’re often unaware of how much we are influenced by the environment around us. Making changes to this environment – from exposing people to a greater proportion of healthier options through to changing the sizes of the utensils we eat and drink from – can help us cut down on potentially unhealthy habits. Even relatively small changes can make a difference both to individuals and at a population level.”

Although some of the non-alcoholic drink options in the current study contained no sugar and were generally lower in calories than the alcoholic options – an average of 64 calories per non-alcoholic drink versus 233 calories per alcoholic drink – many soft drinks and alcohol-free alternatives still contain large amounts of sugar and calories. The researchers argue that, given the health risks associated with sugary drink consumption, continued regulation and policies to reduce sugar content and consumption from both alcoholic and non-alcoholic drinks is needed to mitigate these risks.

The research was funded by Wellcome and carried out at the Behaviour and Health Research Unit, University of Cambridge. Dr Clarke is now a Lecturer in Psychology at Bath Spa University. Dr Hollands is a Principal Research Fellow at UCL.

Reference
Clarke, N et al. Impact on alcohol selection and online purchasing of changing the proportion of available non-alcoholic versus alcoholic drinks: A randomised controlled trial. PLOS Med; 30 Mar 2023; DOI: 10.1371/journal.pmed.1004193

In a study of over 7,500 Irish children, researchers at the University of Cambridge and University College Dublin found that children exposed to ‘hostile’ parenting at age three were 1.5 times likelier than their peers to have mental health symptoms which qualified as ‘high risk’ by age nine.

Hostile parenting involves frequent harsh treatment and discipline and can be physical or psychological. It may, for example, involve shouting at children regularly, routine physical punishment, isolating children when they misbehave, damaging their self-esteem, or punishing children depending on the parent’s mood.

The researchers charted children’s mental health symptoms at ages three, five and nine. They studied both internalising mental health symptoms (such as anxiety and social withdrawal) and externalising symptoms (such as impulsive and aggressive behaviour, and hyperactivity).

About 10% of the children were found to be in a high-risk band for poor mental health. Children who experienced hostile parenting were much more likely to fall into this group.

Importantly, the study makes clear that parenting style does not completely determine mental health outcomes. Children’s mental health is shaped by multiple risk factors, including gender, physical health, and socio-economic status.

The researchers do argue, however, that mental health professionals, teachers and other practitioners should be alert to the potential influence of parenting on a child who shows signs of having poor mental health. They add that extra support for the parents of children who are already considered to be at risk could help to prevent these problems from developing.

The study was undertaken by Ioannis Katsantonis, a doctoral researcher at the Faculty of Education, University of Cambridge, and Jennifer Symonds, Associate Professor in the School of Education, University College Dublin. It is reported in the journal, Epidemiology and Psychiatric Sciences.

“The fact that one in 10 children were in the high-risk category for mental health problems is a concern and we ought to be aware of the part parenting may play in that,” Katsantonis said. “We are not for a moment suggesting that parents should not set firm boundaries for their children’s behaviour, but it is difficult to justify frequent harsh discipline, given the implications for mental health.”

Symonds said: “Our findings underline the importance of doing everything possible to ensure that parents are supported to give their children a warm and positive upbringing, especially if wider circumstances put those children at risk of poor mental health outcomes. Avoiding a hostile emotional climate at home won’t necessarily prevent poor mental health outcomes from occurring, but it will probably help.”

While parenting is widely acknowledged as a factor influencing children’s mental health, most studies have not investigated how it affects their mental health over time, or how it relates to both internalising and externalising symptoms together.

The researchers used data from 7,507 participants in the ‘Growing up in Ireland’ longitudinal study of children and young people. Mental health data was captured using a standard assessment tool called the Strengths and Difficulties Questionnaire. Each child was given a composite score out of 10 for their externalising and internalising symptoms at ages three, five and nine.

A second standard assessment was used to measure the parenting style children experienced at age three. Parents were profiled based on how far they inclined towards each of three styles: warm parenting (supportive and attentive to their child’s needs); consistent (setting clear expectations and rules); and hostile.

The researchers found that, based on the trajectories along which their mental health symptoms developed between ages three and nine, the children fell into three broad categories. Most (83.5%) were low risk, with low internalising and externalising symptom scores at age three which then fell or remained stable. A few (6.43%) were mild risk, with high initial scores that decreased over time, but remained higher than the first group. The remaining 10.07% were high risk, with high initial scores that increased by age nine.

Hostile parenting raised a child’s chances of being in the high-risk category by 1.5 times, and the mild-risk category by 1.6 times, by age nine. Consistent parenting was found to have a limited protective role, but only against children falling into the ‘mild-risk’ category. To the researchers’ surprise, however, warm parenting did not increase the likelihood of children being in the low-risk group, possibly due to the influence of other factors on mental health outcomes.

Previous research has highlighted the importance of these other factors, many of which the new study also confirmed. Girls, for example, were more likely to be in the high-risk category than boys; children with single parents were 1.4 times more likely to be high-risk, and those from wealthier backgrounds were less likely to exhibit worrying mental health symptoms by middle childhood.

Katsantonis said that the findings underscored the importance of early intervention and support for children who are at risk of mental health difficulties, and that this should involve tailored support, guidance and training for new parents.

“Appropriate support could be something as simple as giving new parents clear, up-to-date information about how best to manage young children’s behaviour in different situations,” he said. “There is clearly a danger that parenting style can exacerbate mental health risks. This is something we can easily take steps to address.”

The European Research Council (ERC) has announced the award of 218 Advanced Grants to outstanding research leaders across Europe, as part of the Horizon Europe programme.

The grants, totalling €544 million, support cutting-edge research in a wide range of fields from medicine and physics to social sciences and humanities.

The ERC is the premier European funding organisation for excellent frontier research. The ERC Advanced Grant funding is amongst the most prestigious and competitive EU funding schemes, providing researchers with the opportunity to pursue ambitious, curiosity-driven projects that could lead to major scientific breakthroughs. Grants are awarded to established, leading researchers with a proven track record of significant research achievements over the past decade.

The University of Cambridge’s grant awardees are:

Anna Korhonen, Professor of Natural Language Processing in the Faculty of Modern and Medieval Languages and Linguistics, for her project Towards Globally Equitable Language Technologies.

Richard Nickl, Professor of Mathematical Statistics in the Department of Pure Mathematics and Mathematical Statistics, for his project Statistical aspects of non-linear inverse problems.

Peter Sewell, Professor of Computer Science at the Computer Laboratory, for his project Secure Foundations: Verified Systems Software Above Full-Scale Integrated Semantics.

Sujit Sivasundaram, Professor of World History at the Faculty of History, for his project Colombo: Layered Histories in the Global South City.

"This funding puts our 218 research leaders, together with their teams of postdoctoral fellows, PhD students and research staff, in pole position to push back the boundaries of our knowledge, break new ground and build foundations for future growth and prosperity in Europe,” said Mariya Gabriel, European Commissioner for Innovation, Research, Culture, Education and Youth.

"These new ERC Advanced Grantees are a testament to the outstanding quality of research carried out across Europe. I am especially pleased to see such a high number of female researchers in this competition and that they are increasingly successful in securing funding. We look forward to seeing the results of the new projects in the years to come, with many likely to lead to breakthroughs and new advances,” said Maria Leptin, ERC President.

The laureates of this grant competition will carry out their projects at universities and research centres in 20 countries in Europe, with the highest number of projects in Germany (37), the UK (35), France (32) and Spain (16). The winners come from all over the world, with 27 nationalities represented, notably Germans (36 researchers), French (32), Italians (21), British (19).

This call for proposals attracted nearly 1,650 applications, which were reviewed by panels of renowned researchers. The overall success rate was 13.2%. Female researchers account for 23% of all applications, their highest participation rate in Advanced Grant calls up to now.

In addition to strengthening Europe's knowledge base, the grants are expected to create more than 2,000 jobs for postdoctoral fellows, PhD students, and other staff at the host institutions. Past recipients have included Nobel laureates and other leading scientists who have gone on to make major contributions to their respective fields.

The statistics and final list of successful candidates are provisional. The Trade and Cooperation Agreement between the European Union and the United Kingdom allows for associating the UK to the current EU research and innovation funding programme, Horizon Europe, subject to the adoption of a Protocol. As this Protocol has not been adopted so far, the UK is still considered “non-associated” to Horizon Europe. The successful proposals of applicants based in a country in the process of associating to Horizon Europe will be eligible for funding only if the relevant Horizon Europe association agreement applies by the time of the signature of the grant agreement. However, successful applicants from UK host institutions can still be funded, provided that they move to a host institution.

Adapted from a press release by the ERC.

The announcement came at the second UK-US Summit for Democracy on 30 March 2023. The prize challenges innovators on both sides of the Atlantic to build solutions that enable collaborative development of artificial intelligence (AI) models, while keeping sensitive information private.

Driven by a shared priority to employ data to help solve critical global challenges in a manner that supports US and UK commitments to democratic values and the fundamental right to privacy, the challenges focused on developing PETs solutions for two scenarios: forecasting pandemic infection and detecting financial crime.

A team led by Professor Nic Lane from the Department of Computer Science and Technology at the University of Cambridge was named joint winner in the financial crime category. Their challenge was to develop a privacy-preserving solution to help tackle the challenge of international money laundering.

Xinchi Qiu, a PhD student in Professor Lane’s lab, said: “We developed an end-to-end privacy-preserving federated learning solution to detect potentially anomalous payments, leveraging a combination of inputs from a number of financial institution and different banks. Our project aims to develop a method that can utilise all the inputs from different institutions while protecting the original data.”

Professor Lane said: "Right now, machine learning with federated and other privacy preserving methods are niche. But in the near future they will be the norm. Most of the world's data is inaccessible for machine learning – however these new methods are making such data available in safe manner. This will be a game changer for many high impact domains that are currently starved of sufficient data, such as health, finance and legal. Our solution shows how this can be done effectively for money laundering, but our methods can migrate to these other domains."

Experts from academic institutions, global technology companies, and privacy start-ups competed for cash prizes from a combined UK-US prize pool of $1.6 million (£1.3 million). The winning solutions combined different PETs to allow the AI models to learn to make better predictions without exposing any sensitive data. This focus on combining privacy approaches encouraged the development of innovative solutions that address practical data privacy concerns in real world scenarios.

In the final phase of the challenges, the privacy guarantees of the solutions were put to the test by ‘red teams’, who attempted to reveal the original data used for training the models. The resilience of the solutions to these attacks determined the final winners.

Michelle Donelan, Secretary of State for the UK Department for Science, Innovation and Technology, said: “Never before has our privacy been so important and we must protect our democratic values by safeguarding the right to privacy. That is why the UK and its allies are collaborating to create innovative technologies that enable public institutions to combat financial crime and promote public health without compromising the confidentiality of the sensitive data they manage.”

UK participants also received support from the UK Information Commissioner’s Office to help them consider how their solutions could demonstrate compliance with key UK data protection regulation principles.

John Edwards, UK Information Commissioner, said: “Privacy enhancing technologies can help analyse data responsibly, lawfully and securely and it will be important for regulators and industry to continue to work together to support responsible innovation in these technologies.”

Arati Prabhakar, Assistant to the President for Science and Technology and Director of the White House Office of Science and Technology Policy, added: “Data has the power to drive solutions to some of our biggest shared challenges, but much of that data is sensitive and needs to be protected.”

Adapted from a press release from the Centre for Data Ethics and Innovation

By performing a famous magic trick for three species of monkey with differing hand structures, scientists have discovered that – in order to deceive – a conjuror needs the same anatomy as their audience.

Psychologists used a sleight-of-hand trick called the French drop, in which an object appears to vanish when a spectator assumes it is taken from one hand by the hidden thumb of the other hand. 

The study, carried out at the University of Cambridge’s Comparative Cognition Lab, found that monkeys lacking opposable thumbs did not fall for the assumption – staying wise to the whereabouts of tasty treats a magician tried to disappear.

The research suggest that sharing a biomechanical ability may be necessary for accurately anticipating the movements of those same limbs in other individuals.

This is true even when those apparently accurate predictions end in befuddlement at the hands of an illusionist. The study is published today in the journal Current Biology.

“Magicians use intricate techniques to mislead the observer into experiencing the impossible. It is a great way to study blind spots in attention and perception,” said Dr Elias Garcia-Pelegrin, who has practiced magic for a decade, and conducted the experimental work during his PhD at Cambridge.

“By investigating how species of primates experience magic, we can understand more about the evolutionary roots of cognitive shortcomings that leave us exposed to the cunning of magicians.”

“In this case, whether having the manual capability to produce an action, such as holding an item between finger and thumb, is necessary for predicting the effects of that action in others,” said Garcia-Pelegrin, recently appointed an assistant professor at the National University of Singapore.

The French drop is often the first trick any budding magician sets out to master.

A coin is displayed in one hand. The other hand reaches over and grabs it. The palm of the second hand faces inwards, with the magician’s thumb concealed behind fingers.

The audience knows the thumb is lurking – ready to grip – so assumes the coin has been taken when it is no longer visible. Their attention follows the second hand, only to find it empty at 'the reveal'. The magician had secretly dropped the coin into the palm of the original hand.

Food morsels replaced coins for the monkeys, and were given as rewards – but only if the animals guessed the correct hand. Scientists predicted that monkeys with opposable thumbs would act like human audiences: assume the hidden thumb had grabbed the item, and choose the wrong hand.

They repeatedly performed the French drop on 24 monkeys. Eight capuchins were dazzled with peanuts, eight squirrel monkeys with dried mealworms, and eight marmosets with marshmallows.

Capuchins are famed for dexterity, and use stone tools to crack nuts in the wild. They can waggle each finger, and have opposable thumbs allowing 'precision grip' between thumb and forefingers.  

The capuchins were regularly fooled by the French drop (81% of the time). They mostly chose the empty second hand, and experienced a paucity of peanuts as a result.

Squirrel monkeys are much less dextrous than capuchins, with limited thumb rotation, but can oppose their thumbs. As such, they are still familiar with a hidden thumb interacting with fingers. However, they cannot perform a ‘precision grip’ in the same way as capuchins and humans. 

Yet squirrel monkeys were routinely misled by vanishing mealworms (93% of the time). “Squirrel monkeys cannot do full precision grips, but they were still fooled. This suggests that a monkey doesn’t have to be expert in a movement in order to predict it, just roughly able to do it,” said Garcia-Pelegrin.

Marmosets do not have opposable thumbs. Their thumbs align with their fingers to make five equidistant digits, ideal for climbing thick tree trunks. Marmosets were rarely taken in by magic (just 6% of the time). They simply chose the hand in which the marshmallow was initially placed, and stuck with it. 

Previous work from the Cambridge team shows that species without hands at all, in this case birds from the corvid family, namely Eurasian jays, make similar choices as marmosets when confronted with the French drop.

The team also tried nullifying the tricks by actually completing the hand-to-hand transfers, instead of misdirecting with a French drop. This time, the capuchins and squirrel monkeys anticipated correctly and dined out, and the marmosets missed out.

Finally, the scientists devised their own version of the French drop, which they call the “Power drop”. It utilises a hand action that all the monkey species can perform – essentially a full fist grab. The power drop fooled all of the monkey species the vast majority of the time.

“There is increasing evidence that the same parts of the nervous system used when we perform an action are also activated when we watch that action performed by others,” said Prof Nicola Clayton FRS, senior author of the study from Cambridge’s Department of Psychology.

“This mirroring in our neural motor system might explain why the French drop worked for the capuchins and squirrel monkeys but not for marmosets.”

“It’s about the embodiment of knowledge,” added Clayton. “How one’s fingers and thumbs move helps to shape the way we think, and the assumptions we make about the world – as well as what others might see, remember and anticipate, based on their expectations.”

“Our work raises the intriguing possibility that an individual’s inherent physical capability heavily influences their perception, their memory of what they think they saw, and their ability to predict manual movements of those around them.”

Another co-author of the study, Clive Wilkins, Artist in Residence at Cambridge’s Department of Psychology, is a professional magician and Member of the Magic Circle.

An international team of researchers used high-resolution imagery of the seafloor to reveal just how quickly a former ice sheet that extended from Norway retreated at the end of the last Ice Age, about 20,000 years ago. 

The team, including researchers from the University of Cambridge, mapped more than 7,600 small-scale landforms called corrugation ridges across the seafloor. The ridges are less than 2.5 metres high and are spaced between about 25 and 300 metres apart.

These landforms are understood to have formed when the ice sheet’s retreating margin moved up and down with the tides, pushing seafloor sediments into a ridge every low tide. Given that two ridges would have been produced each day, the researchers were able to calculate how quickly the ice sheet retreated.

Their results, reported in the journal Nature, show the former ice sheet underwent pulses of rapid retreat at a speed of 50 to 600 metres per day. This is much faster than any ice sheet retreat rate that has been observed from satellites or inferred from similar landforms in Antarctica.

“Our research provides a warning from the past about the speeds that ice sheets are physically capable of retreating at,” said Dr Christine Batchelor from Newcastle University, who led the research. “Our results show that pulses of rapid retreat can be far quicker than anything we’ve seen so far.”

Information about how ice sheets behaved during past periods of climate warming is important to inform computer simulations that predict future ice sheet and sea-level change. 

“This study shows the value of acquiring high-resolution imagery about the glaciated landscapes that are preserved on the seafloor,” said co-author Dr Dag Ottesen from the Geological Survey of Norway, who is involved in the MAREANO seafloor mapping programme that collected the data.

The new research suggests that periods of such rapid ice-sheet retreat may only last for short periods of time: from days to months.

“This shows how rates of ice-sheet retreat averaged over several years or longer can conceal shorter episodes of more rapid retreat,” said co-author Professor Julian Dowdeswell from Cambridge’s Scott Polar Research Institute. “It is important that computer simulations are able to reproduce this ‘pulsed’ ice-sheet behaviour.”

The seafloor landforms also shed light into the mechanism by which such rapid retreat can occur. The researchers found that the former ice sheet had retreated fastest across the flattest parts of its bed.

“An ice margin can unground from the seafloor and retreat near-instantly when it becomes buoyant,” said co-author Dr Frazer Christie, also from the Scott Polar Research Institute. “This style of retreat only occurs across relatively flat beds, where less melting is required to thin the overlying ice to the point where it starts to float.”

The researchers conclude that pulses of similarly rapid retreat could soon be observed in parts of Antarctica. This includes at West Antarctica’s vast Thwaites Glacier, which is the subject of considerable international research due to its potential susceptibility to unstable retreat. The authors of this new study suggest that Thwaites Glacier could undergo a pulse of rapid retreat because it has recently retreated close to a flat area of its bed.

“Our findings suggest that present-day rates of melting are sufficient to cause short pulses of rapid retreat across flat-bedded areas of the Antarctic Ice Sheet, including at Thwaites”, said Batchelor. “Satellites may well detect this style of ice-sheet retreat in the near future, especially if we continue our current trend of climate warming.”

Other co-authors are Dr Aleksandr Montelli and Evelyn Dowdeswell at the Scott Polar Research Institute, Dr Jeffrey Evans at Loughborough University, and Dr Lilja Bjarnadóttir at the Geological Survey of Norway. The study was supported by Peterhouse, Cambridge, the Faculty of Humanities and Social Sciences at Newcastle University, the Prince Albert II of Monaco Foundation, and the Geological Survey of Norway.

Reference:
Christine L. Batchelor et al. ‘Rapid, buoyancy-driven ice-sheet retreat of hundreds of metres per day’. Nature (2023), DOI: 10.1038/s41586-023-05876-1

Adapted from a press release by Newcastle University.

An international team, including researchers from the University of Cambridge, drew on readings of medieval texts, along with ice core and tree ring data, to accurately date some of the biggest volcanic eruptions the world has ever seen. Their results, reported in the journal Nature, uncover new information about one of the most volcanically active periods in Earth’s history, which some think helped to trigger the Little Ice Age, a long interval of cooling that saw the advance of European glaciers.

It took the researchers, led by the University of Geneva (UNIGE), almost five years to examine hundreds of annals and chronicles from across Europe and the Middle East, in search of references to total lunar eclipses and their colouration.

Total lunar eclipses occur when the moon passes into the Earth’s shadow. Typically, the moon remains visible as a reddish orb because it is still bathed in sunlight bent round the Earth by its atmosphere. But after a very large volcanic eruption, there can be so much dust in the stratosphere – the middle part of the atmosphere starting roughly where commercial aircraft fly – that the eclipsed moon almost disappears.

Medieval chroniclers recorded and described all kinds of historical events, including the deeds of kings and popes, important battles, and natural disasters and famines. Just as noteworthy were the celestial phenomena that, to the chroniclers, might foretell such calamities. Mindful of the Book of Revelation, a vision of the end times that speaks of a blood-red moon, the monks were especially careful to take note of the moon’s colouration.

Of the 64 total lunar eclipses that occurred in Europe between 1100 and 1300, the chroniclers had faithfully documented 51. In five of these cases, they also reported that the moon was exceptionally dark.

Asked what made him connect the monks’ records of the brightness and colour of the eclipsed moon with volcanic gloom, the lead author of the work, UNIGE’s Sébastien Guillet said: “I was listening to Pink Floyd's Dark Side of the Moon album when I realised that the darkest lunar eclipses all occurred within a year or so of major volcanic eruptions. Since we know the exact days of the eclipses, it opened the possibility of using the sightings to narrow down when the eruptions must have happened.”

The researchers found that scribes in Japan took equal note of lunar eclipses. One of the best known, Fujiwara no Teika, wrote of an unprecedented dark eclipse observed on 2 December 1229: ‘the old folk had never seen it like this time, with the location of the disk of the Moon not visible, just as if it had disappeared during the eclipse... It was truly something to fear.’

The stratospheric dust from large volcanic eruptions was not only responsible for the vanishing moon. It also cooled summer temperatures by limiting the sunlight reaching the Earth’s surface. This in turn could bring ruin to agricultural crops.

“We know from previous work that strong tropical eruptions can induce global cooling on the order of roughly 1°C over a few years,” said Markus Stoffel from the University of Geneva, a specialist in converting measurements of tree rings into climate data, who co-designed the study. “They can also lead to rainfall anomalies with droughts in one place and floods in another.”

Despite these effects, people at the time could not have imagined that the poor harvests or the unusual lunar eclipses had anything to do with volcanoes – the eruptions themselves were all but one undocumented.

“We only knew about these eruptions because they left traces in the ice of Antarctica and Greenland,” said co-author Professor Clive Oppenheimer from Cambridge’s Department of Geography. “By putting together the information from ice cores and the descriptions from medieval texts we can now make better estimates of when and where some of the biggest eruptions of this period occurred.”

To make the most of this integration, Guillet worked with climate modellers to compute the most likely timing of the eruptions. “Knowing the season when the volcanoes erupted is essential, as it influences the spread of the volcanic dust and the cooling and other climate anomalies associated with these eruptions,” he said.

As well as helping to narrow down the timing and intensity of these events, what makes the findings significant is that the interval from 1100 to 1300 is known from ice core evidence to be one of the most volcanically active periods in history. Of the 15 eruptions considered in the new study, one in the mid-13th century rivals the famous 1815 eruption of Tambora that brought on ‘the year without a summer’ of 1816. The collective effect of the medieval eruptions on Earth’s climate may have led to the Little Ice Age, when winter ice fairs were held on the frozen rivers of Europe.

“Improving our knowledge of these otherwise mysterious eruptions, is crucial to understanding whether and how past volcanism affected not only climate but also society during the Middle Ages,” said Guillet.

The research was supported in part by the Swiss National Science Foundation.

Reference:
Sébastien Guillet et al. ‘Lunar eclipses illuminate timing and climate impact of medieval volcanism.’ Nature (2023). DOI: 10.1038/s41586-023-05751-z

The findings, from the Atacama Cosmology Telescope collaboration involving researchers from the University of Cambridge, provide further support to Einstein’s theory of general relativity, which has been the foundation of the standard model of cosmology for more than a century. The results offer new methods to demystify dark matter, the unseen mass thought to account for 85% of the matter in the universe.

For millennia, humans have been fascinated by the mysteries of the cosmos. From ancient civilisations such as the Babylonians, Greeks, and Egyptians to modern-day astronomers, the allure of the starry sky has inspired countless quests to unravel the secrets of the universe.

And although models that explain the cosmos have existed for centuries, the field of cosmology, where scientists use quantitative methods to understand the evolution and structure of the universe, is relatively new—having only formed in the early 20th century with the development of Albert Einstein’s theory of general relativity. 

Now, a set of papers submitted to The Astrophysical Journal by researchers from the Atacama Cosmology Telescope (ACT) collaboration has produced a new image that reveals the most detailed map of matter distributed across a quarter of the entire sky, reaching deep into the cosmos. It confirms Einstein’s theory about how massive structures grow and bend light, with a test that spans the entire age of the universe.

“We have mapped the invisible dark matter across the sky to the largest distances, and clearly see features of this invisible world that are hundreds of millions of light-years across,” said co-author Professor Blake Sherwin from Cambridge’s Department of Applied Mathematics and Theoretical Physics, where he leads a group of ACT researchers. “It looks just as our theories predict.”

Although dark matter makes up a large chunk of the universe and shaped its evolution, it has remained hard to detect because it doesn’t interact with light or other forms of electromagnetic radiation. As far as we know, dark matter only interacts with gravity. 

To track it down, the more than 160 collaborators who have built and gathered data from the National Science Foundation’s Atacama Cosmology Telescope in the high Chilean Andes observe light emanating following the dawn of the universe’s formation, the Big Bang—when the universe was only 380,000 years old. Cosmologists often refer to this diffuse light that fills our entire universe as the “baby picture of the universe,” but formally, it is known as the cosmic microwave background radiation (CMB).

The team tracks how the gravitational pull of large, heavy structures including dark matter warps the CMB on its 14-billion year journey to us, like how a magnifying glass bends light as it passes through its lens.

“We’ve made a new mass map using distortions of light left over from the Big Bang,” said Mathew Madhavacheril from the University of Pennsylvania, lead author of one of the papers. “Remarkably, it provides measurements that show that both the ‘lumpiness’ of the universe, and the rate at which it is growing after 14 billion years of evolution, are just what you’d expect from our standard model of cosmology based on Einstein's theory of gravity.” 

“Our results also provide new insights into an ongoing debate some have called ‘The Crisis in Cosmology’,” said Sherwin. This crisis stems from recent measurements that use a different background light, one emitted from stars in galaxies rather than the CMB. These have produced results that suggest the dark matter was not lumpy enough under the standard model of cosmology and led to concerns that the model may be broken. However, the team’s latest results from ACT were able to precisely assess that the vast lumps seen in this image are the exact right size. 

“When I first saw them, our measurements were in such good agreement with the underlying theory that it took me a moment to process the results,” said Cambridge PhD candidate Frank Qu, lead author of one of the new papers. “But we still don’t know what the dark matter is, so it will be interesting to see how this possible discrepancy between different measurements will be resolved.”

“The CMB lensing data rivals more conventional surveys of the visible light from galaxies in their ability to trace the sum of what is out there,” said Suzanne Staggs from Princeton University, Director of ACT. “Together, the CMB lensing and the best optical surveys are clarifying the evolution of all the mass in the universe.” 

“When we proposed this experiment in 2003, this measurement wasn’t even on our agenda; we had no idea the full extent of information that could be extracted from our telescope,” said Mark Devlin, from the University of Pennsylvania, Deputy Director of ACT. “We owe this to the cleverness of the theorists, the many people who built new instruments to make our telescope more sensitive, and the new analysis techniques our team came up with.”

With ACT having been decommissioned in late 2022, further papers highlighting some of the other final results are slated for submission in the coming year. Observations will continue at the site with the Simons Observatory, including a new telescope due to begin in 2024 that can map the sky almost ten times faster.

The pre-print articles highlighted in this release are available on act.princeton.edu and will appear on the open-access arXiv.org. They have been submitted to The Astrophysical Journal. 

This work was supported by the U.S. National Science Foundation, Princeton University, the University of Pennsylvania, and a Canada Foundation for Innovation award. Team members at the University of Cambridge were supported by the European Research Council.

The study, by University of Cambridge researchers, is the first to examine the long-term effects of different types of third-party assisted reproduction on parenting and child adjustment, as well as the first to investigate prospectively the effect of the age at which children were told that they were conceived by egg donation, sperm donation or surrogacy.

The results, published today in Developmental Psychology, suggest that the absence of a biological connection between children and parents in assisted reproduction families does not interfere with the development of positive relationships between them or psychological adjustment in adulthood. These findings are consistent with previous assessments at age one, two, three, seven, ten and 14.

The findings overturn previous widely held assumptions that children born by third-party assisted reproduction are at a disadvantage when it comes to wellbeing and family relationships because they lack a biological connection to their parents.

“Despite people's concerns, families with children born through third-party assisted reproduction – whether that be an egg donor, sperm donor or a surrogate – are doing well right up to adulthood,” said Susan Golombok, Professor Emerita of Family Research and former Director of the Centre for Family Research, University of Cambridge, who led the study.

However, they found that mothers who began to tell their children about their biological origins in their preschool years had more positive relationships with them as assessed by interview at age 20, and the mothers showed lower levels of anxiety and depression. Most of the parents who had disclosed did so by age four and found that the child took the news well. This suggests that being open with children about their origins when they are young is advantageous.

In addition, in the final stage of this 20-year study, mothers who had disclosed their child’s origins by seven years old obtained slightly more positive scores on questionnaire measures of quality of family relationships, parental acceptance (mother’s feelings towards young adult), and family communication. For example, only 7% of mothers who had disclosed by age 7 reported problems in family relationships, compared with 22% of those who disclosed after age 7.

The young adults who had been told about their origins before seven obtained slightly more positive scores on questionnaire measures of parental acceptance (young adult’s perception of mother’s feelings towards them), communication (the extent to which they feel listened to, know what’s happening in their family and receive honest answers to questions), and psychological wellbeing. They were also less likely to report problems on the family relationships questionnaire; whereas 50% of young adults told after age 7 reported such problems, this was true of only 12.5% of those told before age 7.

“There does seem to be a positive effect of being open with children when they’re young – before they go to school – about their conception. It’s something that’s been shown by studies of adoptive families too,” said Golmobok.

Researchers from the University of Cambridge followed 65 UK families with children born by assisted reproduction ­– 22 by surrogacy, 17 by egg donation and 26 by sperm donation – from infancy through to early adulthood (20 years old). They compared these families with 52 UK unassisted conception families over the same period.

“The assisted reproduction families were functioning well, but where we did see differences, these were slightly more positive for families who had disclosed,” said Golombok.

Reflecting on their feelings about their biological origins, the young adults were generally unconcerned. As one young adult born through surrogacy put it, “It doesn’t faze me really, people are born in all different ways and if I was born a little bit differently - that’s OK, I understand.”

Another young adult born through sperm donation said, “My dad’s my dad, my mum’s my mum, I've never really thought about how anything’s different so, it's hard to put, I don’t really care.”

Some young adults actively embraced the method of their conception as it made them feel special, “I think it was amazing, I think the whole thing is absolutely incredible. Erm…I don’t have anything negative to say about it at all.”

Researchers found that egg donation mothers reported less positive family relationships than sperm donation mothers. They suggest that this could be due to some mothers’ insecurities about the absence of a genetic connection to their child. This was not reflected in the young adults’ perceptions of the quality of family relationships.

The team also found that young adults conceived by sperm donation reported poorer family communication than those conceived by egg donation. This could be explained by the greater secrecy around sperm donation than egg donation, sometimes driven by greater reluctance of fathers than mothers to disclose to their child that they are not their genetic parent, and a greater reluctance to talk about it once they have disclosed.

In fact, researchers found that only 42% of sperm donor parents disclosed by age 20, compared to 88% of egg donation parents and 100% of surrogate parents.

“Today there are so many more families created by assisted reproduction that it just seems quite ordinary,” said Golombok. “But twenty years ago, when we started this study, attitudes were very different. It was thought that having a genetic link was very important and without one, relationships wouldn’t work well.

“What this research means is that having children in different or new ways doesn’t actually interfere with how families function. Really wanting children seems to trump everything – that’s what really matters.”

This research was funded by a Wellcome Trust Collaborative Award.

Golombok, S., Jones, C., Hall, P., Foley, S., Imrie, S., &  Jadva, V. A longitudinal study of families formed through third-party assisted reproduction: Mother-child relationships and child adjustment from infancy to adulthood. Developmental Psychology DOI: 10.1037/dev0001526

The Centre for Family Research is collaborating with the Fitzwilliam Museum on a new exhibition, Real Families: Stories of Change (October – 7 January 2024), curated by Professor Golombok. The exhibition will explore the intricacies of families and family relationships through the eyes of artists including Paula Rego, Chantal Joffe, JJ Levine, Lucian Freud and Tracey Emin.

Professor Susan Golombok is author of We Are Family: What Really Matters for Parents and Children (Scribe) which describes researching new family forms from the 1970s to the present day.

Cattle-rearing is the biggest cause of tropical deforestation in the Amazon - and the world.

A study has found that some of the world’s largest slaughterhouses reduced cattle-driven deforestation in the Amazon by 15% - equivalent to sparing 7,000km2 of forest from clearance (4.5 times the size of London) - through their commitment to zero-deforestation policies between 2010 and 2018.

If these policies were fully implemented and adopted across all cattle companies operating in the Amazon, 24,000km2 of forest (an area larger than Wales) could have been spared over this time, effectively halving cattle-driven deforestation in Brazil.

Deforestation is the second largest contributor to global greenhouse gas emissions after fossil fuel use, and the Brazilian Amazon is the world’s deforestation hotspot.

Zero-deforestation commitments are supply chain policies aiming to ensure production of goods does not involve deforestation, by identifying and dropping suppliers who produce on areas recently cleared of natural vegetation. The commitments have been signed by many leading UK beef retailers, including the supermarkets Tesco, Sainsbury’s, and Waitrose.

Although the UK imported 60 million tonnes of Brazilian beef in 2017, according to the National Beef Association the UK is 75% self-sufficient for beef. Many British companies are increasingly turning away from Brazilian beef due to the perceived risk of deforestation. But the researchers argue that this is not the best approach.

“We can benefit the climate by eating less meat in general. But when it comes to deforestation, the solution is not to avoid beef from specific countries – because then we lose our power to make a difference in those places,” said Professor Rachael Garrett, Moran Professor of Conservation and Development at the University of Cambridge Conservation Research Institute, senior author of the report.

She added: “If we do eat imported beef, we should buy it from retailers that are trying to improve cattle production systems in Brazil and elsewhere. If enough countries join the UK and EU in purchasing only deforestation-free beef it’s likely to have a positive impact on the planet by reducing deforestation.”

The results are published today in the journal Global Environmental Change.

Due to the complexity of Brazilian supply chains and incomplete availability of public records, it has been challenging until now to determine how much of the cattle in any given region was being purchased by companies with zero-deforestation commitments. This impeded efforts to analyse the effectiveness of zero-deforestation policies linked to beef and leather goods - such as shoes and handbags.

The researchers traced the links between farming regions, slaughterhouses and companies with zero-deforestation commitments in the Brazilian Amazon cattle sector, to see how these links influenced deforestation.

An agreement called G4 is the most widespread and strongly implemented zero-deforestation commitment for cattle in the Brazilian Amazon – accounting for over 99% of cattle exports. The study focused on companies that have adopted the G4 Agreement, and found they were associated with substantial reductions in deforestation.

“We’ve shown that zero-deforestation policies are having an important - and measurable – impact in protecting forests, and that with widespread adoption and rigorous implementation they could achieve a lot more,” said Garrett.

She added: “Even reducing deforestation by 15% is a huge amount. But this result shows that supply chain policies have significant limitations, and we need to couple them with more visionary approaches to help countries like Brazil improve their agricultural systems.”

The researchers say a mix of interventions by the private and public sector is needed to improve cattle-rearing practices and help eliminate deforestation in countries like Brazil.

Public sector interventions could include support for alternative economic activities, and financial incentives or greater pressure to avoid deforestation from the Brazilian government.

“With this evidence, supermarkets can use their influence to help improve Brazilian cattle production. But more needs to be done to improve the rigour of corporate policies and the market coverage of policy adopters, even in relatively well-covered regions such as the Brazilian Amazon,” said Dr Sam Levy at ETH Zurich and New York University, lead author of the report.

Cattle production for beef and leather is the cause of over 70% of all deforestation in the Amazon – much of which is illegal. Zero-deforestation commitments cover 82% of beef exported from the Brazilian Amazon for trade internationally – but a large amount of beef production destined for Brazil’s domestic markets is not covered.

Deforestation causes the loss of diverse animal and plant life, threatens the livelihoods of indigenous groups, and increases inequality and conflict.

In 2021, the COP26 Glasgow Leaders’ Declaration on Forests and Land Use committed to halt and reverse deforestation by 2030. It was signed by over 100 countries, representing 85% of global forests.

The research was funded by the National Science Foundation, Gordon and Betty Moore Foundation, and the European Research Council.

Reference

Levy, S A et al: ‘Deforestation in the Brazilian Amazon could be halved by scaling up implementation of zero-deforestation cattle commitments.’ Global Environmental Change, April 2023. DOI: 10.1016/j.gloenvcha.2023.102671

See also: Companies' deforestation-free supply chain pledges have barely impacted forest clearance in the Amazon

Their analysis, published today in BMJ Open, also found that while female applicants are more successful overall, particular specialities tend to appeal to different genders.

Researchers from the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust examined data from applicants to Specialty Training Posts through Health Education England for the recruitment cycle 2021-22 to look at potential disparities in the success of applicants according to gender, ethnicity and disability.

During this period, there were just under 12,500 successful applicants to Health Education England for training posts – a success rate of one in three (32.7%). Overall, females were more successful than males (37.0% versus 29.1%).

The researchers found clear evidence that certain specialities were more attractive to females or to males. Of note, surgical specialities and radiology had the highest proportion of male applicants (65.3% and 64.3% respectively), while obstetrics and gynaecology and public health had the highest proportion of female applicants (72.4% and 67.2% respectively).

Senior author Professor Sharon Peacock, from the Department of Medicine at the University of Cambridge, said: “The success by female applicants in many specialties is a positive step towards gender balance, and perhaps reflects existing efforts to address disparities. But the skew in applications and subsequent recruitment by gender, particularly amongst surgical specialities, is concerning.”

Gender disparities are known to have knock-on effects. For example, a lack of female representation contributes towards a male dominated culture, which can then result in fewer female role models to inspire and encourage aspiring female doctors.

The researchers say there are several reasons for these disparities. In surgical specialities, for example, a male-dominated workplace culture, bullying and harassment, few female role models, and career inflexibility, have been suggested as factors that deter females from applying. Female surgeons have reported quality of life and fewer unsocial hours as explanations of why women prefer other clinical specialities, in addition to the fear that working less-than-full-time or taking career breaks is perceived negatively.

Approximately half (50.2%) of the applicants were non-UK graduates. The overall success rate of UK graduates was 44.5%, compared with 22.8% for non-UK graduates.

When it came to minority ethnic groups, after adjusting for country of graduation, applicants from eleven out of fifteen groups (73.3%) were significantly less likely to be successful compared to White British. Those who fared worst were those of Mixed White and Black African ethnicity, who were only half as likely (52%) to be successful as White British applicants.

Dr Dinesh Aggarwal, the study’s first author, also from the Department of Medicine, said: “The data suggests there’s a need to review recruitment policies and processes from a diversity and inclusion perspective. But the issues extend beyond recruitment – doctors from minority ethnic groups can struggle to progress within the NHS and report disproportionately high levels of discrimination from colleagues.

“More than four in ten of the medical and dental workforce in NHS trusts and clinical commissioning groups in England are from a minority ethnic group, and ensuring that they are able to work within an inclusive environment, that allows them to thrive and progress, should be a priority.”

Although only a very small proportion of successful applicants (1.4%) declared a disability, they were more likely to be successful (38.6% compared with 32.8% of non-disabled applicants). However, there were no disabled applicants to 22.4% of the specialities, and for a further 36.2% of specialities, no disabled applicants were accepted.

Dr Dinesh Aggarwal added: “It’s encouraging to see a high proportion of acceptances among individuals disclosing a disability. The NHS needs to ensure that application and recruitment processes are accessible and open to adjustments for all disabilities, eliminate any fear of discrimination, and provide assurance that all NHS workplaces will accommodate reasonable adjustments to ensure that disabled doctors can carry out their work. This will not only help to encourage more disabled applicants, but also allow disabled clinicians to feel more comfortable disclosing this information.”

Professor Peacock added: “The NHS is the largest employer in the UK and it’s vital that it nurtures diverse talent to benefit patient care. People from diverse backgrounds bring different lived experiences and perspectives, which in turn strengthens the pool of knowledge and skills within the NHS. A lack of workforce diversity can be detrimental to patient care, and research shows that inherent biases can influence how clinicians treat patients.”

Dr Aggarwal is a PhD student at Churchill College. Professor Peacock is a Fellow at St John’s College.

Reference
Aggarwal, D et al. Applications to medical and surgical specialist training in the UK National Health Service, 2021-22: a cross-sectional observational study to characterise the diversity of successful applicants. BMJ Open; 20 April 2023; DOI: 10.1136/bmjopen-2022-069846