Museum events, science talks and networking opportunities are among the activities highlighting the social, economic, cultural, and political achievements of women. This year’s International Women’s Day events include:

Snow Widows: A talk by Katherine MacInness – Scott Polar Museum

Saturday 4 March, 1.30pm to 2.15pm

Join us at the Polar Museum with author Katherine MacInnes to celebrate International Women's Day. Discover the untold stories of the race for the South Pole from the perspective of the women whose lives would be forever changed by it. Katherine MacInness is the author of Snow Widows, a book that gives a voice to five remarkable women; separated by class, education and religion but forever joined by their stories in the heroic age of exploration.

More information here

Navigating Multiple Identities: Reflections on Being a Woman – Hughes Hall

Tuesday 7 March, 5.30pm to 7pm, Pavilion Room

This Postdoc-led International Women’s Day event will bring together inspiring speakers from a variety of backgrounds – one thing they have in common is being women of Hughes Hall!
After our speakers’ introductions, we will have a Q&A and panel conversation about navigating life and careers as women, celebrate women’s strengths, and touch on gender equality issues in the world.

More information here 

Service for International Women’s Day – King’s College Chapel

Wednesday 8 March, 5.30pm

A special Evensong in the King’s Chapel will be sung by King’s Voices.

More information here

International Women’s Day 2023 – Building an Equitable Future for All – Judge Business School

Panel discussion and networking event, Wednesday 8 March, 6pm to 8pm

On International Women’s Day, join the Wo+men’s Leadership Centre at Cambridge Judge Business School, as we look at how we can all take meaningful action to help build a diverse, equitable and inclusive workplace culture.
Our panel of speakers will discuss how fostering a culture of allyship can act as a powerful force for good – helping employees at every level identify ways they can take action to create a positive impact.

More information here

International Women’s Day with Professor Rebecca Kilner – Museum of Zoology

Thursday 9 March, 6pm to 7pm

Professor Rebecca Kilner, Director of the Museum of Zoology, will take part in a live online talk and Q&A. Hear about her fascinating research into animal behaviour, and how recent work on the parental behaviour of burying beetles is changing our understanding of evolution. Ask your questions and find out more about the Museum, its collections, and how they are being harnessed for research and engagement.

More information here

Hear, There and Everywhere – a World of Women Composers – West Road Concert Hall

Sunday 12th March, 7pm

Cambridge Concert Orchestra will perform pieces composed solely by women to raise funds for the Cambridge Women's Resources Centre. The event, in recognition of International Women’s Day, focuses on women’s contribution to the light-orchestral repertoire.

More information here 

International Women’s Day celebrations – St Catharine’s College

Throughout March

St Catharine’s College has organised a host of activities marking the vital role of women in history. Events include storytelling workshops, research seminars, panel discussions and a month-long display in the Shakeshaft Library, featuring items from our archive since women were first admitted as undergraduates in 1979.

More information here 

Illustration by Allysa Czerwinsky

The spears were taken by Lieutenant James Cook in 1770 from Kamay (Botany Bay) at the time of the first contact between the crew of the HMB Endeavour and the Aboriginal people of eastern Australia.

Trinity College has agreed to permanently return the four spears to the La Perouse Aboriginal community. The College is now approaching the UK’s Charity Commission to obtain approval for this transfer of legal title.

James Cook recorded that 40 spears were taken from the camps of Aboriginal people living at Botany Bay in April 1770. 

Lord Sandwich of the British Admiralty presented the four spears to Trinity College soon after James Cook returned to England and they have been part of the collection since 1771.  Since 1914 the four spears have been cared for by the Museum of Archaeology and Anthropology (MAA). The four spears are all that remain of the original 40 spears collected. 

Trinity College’s decision follows the establishment of a respectful and robust relationship over the last decade between the Museum of Archaeology and Anthropology and the Aboriginal community at La Perouse. Discussions included representatives of the local Gweagal people - the Aboriginal group from whom the spears were taken - the broader Dharawal Nation and leading community organisations, including the La Perouse Local Aboriginal Land Council and the Gujaga Foundation. 

The relationship between Cambridge and La Perouse will continue through collaborative research projects and community visits, once the spears have been returned. 

The La Perouse community is currently lending contemporary spears made by Senior Gweagal Clan leader Rodney Mason to the Museum of Archaeology and Anthropology to show how traditional knowledge has been passed down, while adapting to new technologies.

The decision by Trinity College to return the spears followed a formal repatriation request in December 2022, from the La Perouse Local Aboriginal Land Council and the Gujaga Foundation.

In 2015 and again in 2020, some of the spears were returned temporarily to Australia, for the first time since they were taken, and displayed by the National Museum of Australia in Canberra, as part of two exhibitions exploring frontier encounters.

The spears will be permanently repatriated with the assistance of the Australian Institute of Aboriginal and Torres Strait Islander Studies (AIATSIS).

La Perouse Local Aboriginal Land Council chairperson, Noeleen Timbery said the spears would be preserved for future generations.

“We are proud to have worked with Cambridge’s Trinity College and the Museum of Archaeology and Anthropology to transfer the ownership of these enormously significant artefacts to the La Perouse Aboriginal community. They are an important connection to our past, our traditions and cultural practices, and to our ancestors. With assistance from the National Museum of Australia and AIATSIS we will ensure these objects are preserved for our future generations and for all Australians. 

"Our Elders have worked for many years to see their ownership transferred to the traditional owners of Botany Bay. Many of the families within the La Perouse Aboriginal community are descended from those who were present during the eight days the Endeavour was anchored in Kamay in 1770,” said Ms Timbery.

Professor Nicholas Thomas, Director of the Museum of Archaeology and Anthropology, said he was honoured to have worked with the Kamay community to repatriate the spears.

“It has been immensely rewarding to work with the La Perouse community to research these artefacts and we look forward to extending the partnership into the future,” said Professor Thomas.

"The spears are exceptionally significant. They are the first artefacts collected by any European from any part of Australia, that remain extant and documented. They reflect the beginnings of a history of misunderstanding and conflict. Their significance will be powerfully enhanced through return to the country."

Dame Sally Davies, Master of Trinity College, welcomed the decision to return the spears.

“Trinity is committed to better understanding the College’s history, and to addressing the complex legacies of the British empire, not least in our collections,” said Professor Davies.

“The College’s interaction with the La Perouse Aboriginal community, the University of Cambridge and National Museum Australia regarding the return of artefacts to the people from whom they were taken has been a respectful and rewarding process. 

“We believe that this is the right decision and I would like to acknowledge and thank all those involved."

Dharawal Elder, Dr Shayne Williams said: “These spears are of immeasurable value as powerful, tangible connections between our forebears and ourselves. I want to acknowledge the respectfulness of Trinity College in returning these spears back to our community. In caring for the spears for over 252 years, Trinity College has ensured that these priceless artefacts can now be utilised for cultural education by the Aboriginal community into the future.”
 

Offering a tiny cash reward for accuracy, or even briefly appealing to personal integrity, can increase people’s ability to tell the difference between misinformation and the truth, according to a new study.

The findings suggest that fake news thrives on social media not only because people are tricked into believing it, but also due to a motivational imbalance: users have more incentive to get clicks and likes than to spread accurate content. 

Social psychologists from the University of Cambridge and New York University argue that their study, published in the journal Nature Human Behaviour, highlights the “perverse incentives” driving shares on social media – particularly in “divisive political climates” such as the United States.

They say the psychological pull of pandering to one’s own “in-group” by attacking the other side of a social and political divide is a significant – and often neglected – factor for why so many believe and choose to spread misinformation, or disbelieve accurate news.  

The study involved four experiments with a total of over 3,300 people from the United States, with equal numbers of Democrats and Republicans. The researchers offered half of participants up to one US dollar if they correctly pointed out true or false headlines, and compared the results to those offered no incentive.

This tiny sum was enough to make people 31% better at discerning true from fake news. The best results came when participants were asked to identify accurate news that benefited the opposing political party.

In fact, the financial incentive reduced partisan division between Republican and Democrat over the truthfulness of news by around 30%. The majority of this shift occurred on the Republican side.

For example, the offer of up to a dollar made Republicans 49% more likely to report that the accurate Associated Press headline ‘Facebook removes Trump ads with symbols once used by Nazis’ was indeed true. A dollar made Democrats 20% more likely to report the Reuters headline 'Plant a trillion trees: U.S. Republicans offer fossil-fuel friendly climate fix' as accurate.

However, in another experiment, researchers inverted the set-up to “mirror the social media environment” by paying participants to identify the headlines likely to get the best reception from members of the same political party. The ability to spot misinformation reduced by 16%.

“This is not just about ignorance of facts among the public. It is about a social media business model that rewards the spread of divisive content regardless of accuracy,” said lead author Dr Steve Rathje, who conducted the work while he was a Gates Cambridge Scholar.

“By motivating people to be accurate instead of appealing to those in the same political group, we found greater levels of agreement between Republicans and Democrats about what is actually true.”

Previous research by the same team has shown that attacking political rivals is one of the most effective ways to go viral on Twitter and Facebook.

“Shifting the motivations to post on social media could help rebuild some of the shared reality lost to political polarisation in many nations, including the United States,” said senior author Prof Sander van der Linden, director of the University of Cambridge’s Social Decision-Making Lab.    

In one of the study’s experiments, half the participants were simply exposed to a short piece of text reminding them that people value truth, and falsehoods can hurt reputations. They were also told they would receive feedback on accuracy rates.

While this did not have the same effect as a small pay out, it still increased the perceived accuracy of true but politically inconvenient news by 25% compared to a control group.

“A short piece of text nudging users to consider the social value of truth could be deployed at scale by social media corporations,” said van der Linden.   

Jay Van Bavel, Professor of Psychology at New York University and co-author of the study, said: “It is not possible to pay everyone on the internet to share more accurate information. However, we can change aspects of social media platform design to help motivate people to share content they know to be accurate.”

Providing incentives improved the accuracy of news judgements across the political spectrum, but had a much stronger effect on Republican voters.

The team point to previous research showing that Republicans tend to believe in and share more misinformation than Democrats. In the latest study, payment incentives brought Republicans far closer to the accuracy levels of Democrats – shrinking the political divide.  

“Recent lawsuits have revealed that Fox News hosts shared false claims about ‘stolen’ elections to retain viewers, despite privately disavowing these conspiracy theories. Republican media ecosystems have proved more willing to harness misinformation for profit in recent years,” said Van der Linden, author of the new book Foolproof: why we fall for misinformation and how to build immunity.

The researchers, from the University of Cambridge, developed the algorithm, which gives an accurate measurement of tree diameter, an important measurement used by scientists to monitor forest health and levels of carbon sequestration.

The algorithm uses low-cost, low-resolution LiDAR sensors that are incorporated into many mobile phones, and provides results that are just as accurate, but much faster, than manual measurement techniques. The results are reported in the journal Remote Sensing.

The primary manual measurement used in forest ecology is tree diameter at chest height. These measurements are used to make determinations about the health of trees and the wider forest ecosystem, as well as how much carbon is being sequestered.

While this method is reliable, since the measurements are taken from the ground, tree by tree, the method is time-consuming. In addition, human error can lead to variations in measurements.

“When you’re trying to figure out how much carbon a forest is sequestering, these ground-based measurements are hugely valuable, but also time-consuming,” said first author Amelia Holcomb from Cambridge’s Department of Computer Science and Technology. “We wanted to know whether we could automate this process.”

Some aspects of forest measurement can be carried out using expensive special-purpose LiDAR sensors, but Holcomb and her colleagues wanted to determine whether these measurements could be taken using cheaper, lower-resolution sensors, of the type that are used in some mobile phones for augmented reality applications.

Other researchers have carried out some forest measurement studies using this type of sensor, however, this has been focused on highly-managed forests where trees are straight, evenly spaced and undergrowth is regularly cleared. Holcomb and her colleagues wanted to test whether these sensors could return accurate results for non-managed forests quickly, automatically, and in a single image.

“We wanted to develop an algorithm that could be used in more natural forests, and that could deal with things like low-hanging branches, or trees with natural irregularities,” said Holcomb.

The researchers designed an algorithm that uses a smartphone LiDAR sensor to estimate trunk diameter automatically from a single image in realistic field conditions. The algorithm was incorporated into a custom-built app for an Android smartphone and is able to return results in near real time.

To develop the algorithm, the researchers first collected their own dataset by measuring trees manually and taking pictures. Using image processing and computer vision techniques, they were able to train the algorithm to differentiate trunks from large branches, determine which direction trees were leaning in, and other information that could help it refine the information about forests.

The researchers tested the app in three different forests – one each in the UK, US and Canada – in spring, summer and autumn. The app was able to detect 100% of tree trunks and had a mean error rate of 8%, which is comparable to the error rate when measuring by hand. However, the app sped up the process significantly and was about four and a half times faster than measuring trees manually.

“I was surprised the app works as well as it does,” said Holcomb. “Sometimes I like to challenge it with a particularly crowded bit of forest, or a particularly oddly-shaped tree, and I think there’s no way it will get it right, but it does.”

Since their measurement tool requires no specialised training and uses sensors that are already incorporated into an increasing number of phones, the researchers say that it could be an accurate, low-cost tool for forest measurement, even in complex forest conditions.

The researchers plan to make their app publicly available for Android phones later this spring.

The research was supported in part by the David Cheriton Graduate Scholarship, the Canadian National Research Council, and the Harding Distinguished Postgraduate Scholarship.

Reference:
Amelia Holcomb, Linzhe Tong, and Srinivasan Keshav. ‘Robust Single-Image Tree Diameter Estimation with Mobile Phones.’ Remote Sensing (2023). DOI: 10.3390/rs15030772

The 36 crew members who have won a coveted place in their 'Blue Boat' were announced at an event, hosted by sports broadcaster Andrew Cotter and held at Apothecaries' Hall, Blackfriars. The Blue Boat is the name given to the top crew from each university whose members win the coveted Light Blue colour of Cambridge, or Dark Blue of Oxford.

Cambridge Women:

Bow: Carina Graf (Emmanuel – Phd Neuro Sci)
2: Rosa Millard (Trinity Hall – BA Linguistics)
3: Alex Riddell-Webster (Murray Edways – BA Comp Sci
4: Jenna Armstrong (Jesus – PhD Physiology)
5: Freya Keto (St Edmund’s – MPhil African Studies)
6: Isabelle Bastian (Jesus – MPhil Health, Medicine, and Society)
7: Claire Brillon (Fitzwilliam – MPhil Musicology)
Stroke: Caoimhe Dempsey (Newnham – PhD Psychology)
Cox: James Trotman (Sidney Sussex – BA Economics)

Caoimhe Dempsey, says: "We are focused on going as fast as possible on Boat Race day. Our goal is to leave no stone unturned in the lead up to the race, use every opportunity to put out our best performance. On the day, the result will take care of itself. These girls have been an absolute pleasure to lead, they have a never ending energy and commitment to strive for more. I’m really proud of the journey we’ve been on and it’ll be an honour to line up on race day together.“

Cambridge Men:

Bow: Matt Edge (St Catharine’s – PhD Chem Eng)
2: Brett Taylor (Queens’ – BA Medicine)
3: Noam Mouelle (Hughes Hall – PhD Astrophysics)
4: Seb Benzecry (Jesus – PhD Film Studies)
5: Tom Lynch (Hughes Hall – PhD Engineering)
6: Nick Mayhew (Peterhouse – MPhil Mgt)
7: Oliver Parish (Peterhouse – MEngineering)
Stroke: Luca Ferraro (King’s – BA Classics)
Cox: Jasper Parish (Clare – BA Comp Sci)

Seb Benzecry said: “This year’s crew is a really exciting boat to be a part of. We’re not the most experienced Blue Boat, and we’re on the small side, but everyone has come in with an incredibly positive mindset and an absolute determination to keep improving session after session. I think that’s allowed us to become much more than the sum of our parts."

The crew for Cambridge are all members of, and selected by, Cambridge University Boat Club (CUBC). Patrick Ryan is the Chief Coach for the women's crew and Rob Baker is Chief Coach for the men's.

The Boat Race will take place on Sunday 26 March, on what is known as 'The Championship Course' and stretches four miles between Putney and Mortlake on the River Thames. The 77th Women’s Boat Race begins at 4pm. The 168th Men’s Boat Race begins at 5pm.

The benefits of skin-to-skin contact for both parents and infants are already recognised, but other behaviours common in hunter-gatherer societies may also benefit families in economically developed countries, a Cambridge researcher suggests.

Parents and children may, for instance, benefit from a larger network of people being involved in care-giving, as seen in hunter-gatherer societies. Increasing staff-to-child ratios in nurseries to bring them closer to highly attentive hunter-gatherer ratios could support learning and wellbeing. And more peer-to-peer, active and mixed-age learning, as seen in hunter-gatherer communities, may help school children in developed countries.

Published today in the Journal of Child Psychology and Psychiatry, the study by Dr Nikhil Chaudhary, an evolutionary anthropologist at Cambridge, and Dr Annie Swanepoel, a child psychiatrist, calls for new research into child mental health in hunter-gatherer societies. They explore the possibility that some common aspects of hunter-gatherer childhoods could help families in economically developed countries. Eventually, hunter-gatherer behaviours could inform ‘experimental intervention trials’ in homes, schools and nurseries.

The authors acknowledge that children living in hunter-gatherer societies live in very different environments and circumstances than those in developed countries. They also stress that hunter-gatherer children invariably face many difficulties that are not experienced in developed countries and, therefore, caution that these childhoods should not be idealised.

Drawing on his own observations of the BaYaka people in Congo and the extensive research of anthropologists studying other hunter-gatherer societies, Dr Chaudhary highlights major differences in the ways in which hunter-gatherer children are cared for compared to their peers in developed countries. He stresses that “contemporary hunter-gatherers must not be thought of as ‘living fossils’, and while their ways of life may offer some clues about our prehistory, they are still very much modern populations each with a unique cultural and demographic history”. 

Physical contact and attentiveness

Despite increasing uptake of baby carriers and baby massage in developed countries, levels of physical contact with infants remain far higher in hunter-gatherer societies. In Botswana, for instance, 10-20 week old !Kung infants are in physical contact with someone for around 90% of daylight hours, and almost 100% of crying bouts are responded to, almost always with comforting or nursing – scolding is extremely rare.

The study points out that this exceptionally attentive childcare is made possible because of the major role played by non-parental caregivers, or ‘alloparents’, which is far rarer in developed countries.

Non-parental caregivers

In many hunter-gatherer societies, alloparents provide almost half of a child’s care. A previous study found that in the DRC, Efe infants have 14 alloparents a day by the time they are 18 weeks old, and are passed between caregivers eight times an hour.

Dr Chaudhary said: “Parents now have much less childcare support from their familial and social networks than would likely have been the case during most of our evolutionary history. Such differences seem likely to create the kind of evolutionary mismatches that could be harmful to both caregivers and children.”

“The availability of other caregivers can reduce the negative impacts of stress within the nuclear family, and the risk of maternal depression, which has knock-on effects for child wellbeing and cognitive development.”

The study emphasises that alloparenting is a core human adaptation, contradicting ‘intensive mothering’ narratives which emphasise that mothers should use their maternal instincts to manage childcare alone. Dr Chaudhary and Dr Swanepoel write that ‘such narratives can lead to maternal exhaustion and have dangerous consequences’.

Care-giving ratios

The study points out that communal living in hunter-gatherer societies results in a very high ratio of available caregivers to infants/toddlers, which can even exceed 10:1.

This contrasts starkly with the nuclear family unit, and even more so with nursery settings, in developed countries. According to the UK’s Department of Education regulations, nurseries require ratios of 1 carer to 3 children aged under 2 years, or 1 carer to 4 children aged 2-3.

Dr Chaudhary said: “Almost all day, hunter-gatherer infants and toddlers have a capable caregiver within a couple of metres of them. From the infant’s perspective, that proximity and responsiveness, is very different from what is experienced in many nursery settings in the UK.”

“If that ratio is stretched even thinner, we need to consider the possibility that this could have impacts on children's wellbeing.”

Children providing care and mixed-age active learning

In hunter-gatherer societies, children play a significantly bigger role in providing care to infants and toddlers than is the case in developed countries. In some communities they begin providing some childcare from the age of four and are capable of sensitive caregiving; and it is common to see older, but still pre-adolescent children looking after infants.

By contrast, the NSPCC in the UK recommends that when leaving pre-adolescent children at home, babysitters should be in their late teens at least.

Dr Chaudhary said: “In developed countries, children are busy with schooling and may have less opportunity to develop caregiving competence. However, we should at least explore the possibility that older siblings could play a greater role in supporting their parents, which might also enhance their own social development.”

The study also points out that instructive teaching is rare in hunter-gatherer societies and that infants primarily learn via observation and imitation. From around the age of two, hunter-gatherer children spend large portions of the day in mixed-age (2-16) ‘playgroups’ without adult supervision. There, they learn from one another, acquiring skills and knowledge collaboratively via highly active play practice and exploration.

Learning and play are two sides of the same coin, which contrasts with the lesson-time / play-time dichotomy of schooling in the UK and other developed countries.

Dr Chaudhary and Dr Swanepoel note that “Classroom schooling is often at odds with the modes of learning typical of human evolutionary history.” The study acknowledges that children living in hunter-gatherer societies live in very different environments and circumstances than those in developed countries:

“Foraging skills are very different to those required to make a living in market-economies, and classroom teaching is certainly necessary to learn the latter. But children may possess certain psychological learning adaptations that can be practically harnessed in some aspects of their schooling. When peer and active learning can be incorporated, they have been shown to improve motivation and performance, and reduce stress.” The authors also highlight that physical activity interventions have been shown to aid performance among students diagnosed with ADHD. 

Further research

The study calls for more research into children’s mental health in hunter-gatherer societies to test whether the hypothesised evolutionary mismatches actually exist. If they do, such insights could then be used to direct experimental intervention trials in developed countries.

Working with a team from the Royal College of Psychiatrists, Dr Chaudhary and Dr Swanepoel hope that greater collaboration between evolutionary anthropologists and child psychiatrists/psychologists can help to advance our understanding of the conditions that children need to thrive.

Reference

N Chaudhary and A Swanepoel, ‘What Can We Learn from Hunter-Gatherers about Children’s Mental Health? An Evolutionary Perspective’, Journal of Child Psychology and Psychiatry (2023). DOI: 10.1111/jcpp.13773

For thousands of years, humanity and science have contemplated the origins of life in the Universe. While today’s scientists are well-equipped with innovative technologies, humanity has a long way to go before we fully understand the fundamental aspects of what life is and how it forms.

“We are living in an extraordinary moment in history,” said Professor Didier Queloz, who directs the Leverhulme Centre for Life in the Universe at Cambridge and ETH Zurich’s Centre for Origin and Prevalence of Life. While still a doctoral student, Queloz was the first to discover an exoplanet – a planet orbiting a star other than our Sun. The discovery led to him being awarded the 2019 Nobel Prize in Physics.

In the three decades since Queloz’s discovery, scientists have discovered more than 5,000 exoplanets. Trillions more are predicted to exist within our Milky Way galaxy alone. Each exoplanet discovery raises more questions about how and why life emerged on Earth and whether it exists elsewhere in the universe.

Technological advancements, such as the James Webb Space Telescope and interplanetary missions to Mars, give scientists access to huge volumes of new observations and data. Sifting through all this information to understand the emergence of life in the universe will take a big, multidisciplinary network.

In collaboration with chemist and fellow Nobel Laureate Jack Szostak and astronomer Dimitar Sasselov, Queloz announced the formation of such a network at the American Association for the Advancement of Science (AAAS) meeting in Washington, DC. The Origins Federation brings together researchers studying the origins of life at Cambridge, ETH Zurich, Harvard University, and The University of Chicago.

Together, Federation scientists will explore the chemical and physical processes of living organisms and environmental conditions hospitable to supporting life on other planets. “The Origins Federation builds upon a long-standing collegial relationship strengthened through a shared collaboration in a recently completed project with the Simons Foundation,” said Queloz.

These collaborations support the work of researchers like Dr Emily Mitchell from Cambridge's Department of Zoology. Mitchell is co-director of Cambridge’s Leverhulme Centre for Life in the Universe and an ecological time traveller. She uses field-based laser-scanning and statistical mathematical ecology on 580-million-year-old fossils of deep-sea organisms to determine the driving factors that influence the macro-evolutionary patterns of life on Earth.

Speaking at AAAS, Mitchell took participants back to four billion years ago when Earth’s early atmosphere - devoid of oxygen and steeped in methane – showed its first signs of microbial life. She spoke about how life survives in extreme environments and then evolves offering potential astrobiological insights into the origins of life elsewhere in the universe.

“As we begin to investigate other planets through the Mars missions, biosignatures could reveal whether or not the origin of life itself and its evolution on Earth is just a happy accident or part of the fundamental nature of the universe, with all its biological and ecological complexities,” said Mitchell.

The founding centres of the Origins Federation are The Origins of Life Initiative (Harvard University), Centre for Origin and Prevalence of Life (ETH Zurich), the Center for the Origins of Life (University of Chicago), and the Leverhulme Centre for Life in the Universe (University of Cambridge).

The Origins Federation will pursue scientific research topics of interest to its founding centres with a long-term perspective and common milestones. It will strive to establish a stable funding platform to create opportunities for creative and innovative ideas, and to enable young scientists to make a career in this new field. The Origins Federation is open to new members, both centres and individuals, and is committed to developing the mechanisms and structure to achieve that aim.

“The pioneering work of Professor Queloz has allowed astronomers and physicists to make advances that were unthinkable only a few years ago, both in the discovery of planets which could host life and the development of techniques to study them,” said Professor Andy Parker, head of Cambridge's Cavendish Laboratory. “But now we need to bring the full range of our scientific understanding to bear in order to understand what life really is and whether it exists on these newly discovered planets. The Cavendish Laboratory is proud to host the Leverhulme Centre for Life in the Universe and to partner with the Origins Federation to lead this quest.”

This will help scientists to understand the basic principles by which signals travel through the brain at the neural level and lead to behaviour and learning.  

An organism's nervous system, including the brain, is made up of neurons that are connected to each other via synapses. Information in the form of chemicals passes from one neuron to another through these contact points.

The map of the 3016 neurons that make up the larva of the fruit fly Drosophila melanogaster’s brain, and the detailed circuitry of neural pathways within it, is known as a ‘connectome’.

This is the largest complete brain connectome ever to have been mapped. It is a huge advance on previous work to map very simple brain structures including the roundworm C. elegans, which only has several hundred neurons.

Imaging entire brains has until recently been extremely challenging. Now, technological advances allow scientists to image the entire brain of the fruit fly larvae relatively quickly using electron microscopy, and reconstruct the brain circuits from the resulting data.

The fruit fly larva has similar brain structures to the adult fruit fly and larger insects, and has a rich behavioural repertoire, including learning and action-selection.

“The way the brain circuit is structured influences the computations the brain can do. But, up until this point, we haven’t seen the structure of any brain except in very simple organisms,” said Professor Marta Zlatic at the University of Cambridge’s Department of Zoology and the Medical Research Council Laboratory of Molecular Biology (MRC LMB).

Zlatic led the research together with Professor Albert Cardona at the University of Cambridge’s Department of Physiology, Development and Neuroscience and the MRC LMB, and Dr Michael Winding at the University of Cambridge’s Department of Zoology. The study, which also involved collaborators from both the UK and the US, is published today in the journal Science.

She added: “Until now, the actual circuit patterns involved in most brain computations have been unknown. Now we can start gaining a mechanistic understanding of how the brain works.”

Current technology is not yet advanced enough to map the connectome of more complex animals such as large mammals. But because all brains involve networks of interconnected neurons, the researchers say that their new map will be a lasting reference for future studies of brain function in other animals.

“All brains of all species have to perform many complex behaviours: for example they all need to process sensory information, learn, choose food, and navigate their environment. In the same way that genes are conserved across the animal kingdom, I think that the basic circuit patterns that drive these fundamental behaviours will also be conserved,” said Zlatic.

To build a picture of the fruit fly larva connectome, the team used thousands of slices of the larva’s brain imaged with a high-resolution electron microscope, to reconstruct a map of the fly’s brain - and painstakingly annotated the connections between neurons. As well as mapping the 3016 neurons, they mapped an incredible 548,000 synapses.

The researchers also developed computational tools to identify likely pathways of information flow and different types of circuit patterns in the insect’s brain. They found that some of the structural features are similar to state-of-the-art deep learning architecture.

“The most challenging aspect of this work was understanding and interpreting what we saw. We were faced with a complex neural circuit with lots of structure. In collaboration with Professor Priebe and Professor Vogestein’s groups at Johns Hopkins University, we developed computational tools to predict the relevant behaviours from the structures. By comparing this biological system, we can potentially also inspire better artificial networks,” said Zlatic.

“This is an exciting and significant body of work by colleagues at the MRC Laboratory of Molecular Biology and others,” said Jo Latimer, Head of Neurosciences and Mental Health at the Medical Research Council.

She added: “Not only have they mapped every single neuron in the insect’s brain, but they’ve also worked out how each neuron is connected. This is a big step forward in addressing key questions about how the brain works, particularly how signals move through the neurons and synapses leading to behaviour, and this detailed understanding may lead to therapeutic interventions in the future.”

The next step is to delve deeper to understand, for example, the brain circuitry required for specific behavioural functions, such as learning and decision making, and to look at activity in the whole connectome while the insect is doing things.

Adapted from a press release by the Medical Research Council

Reference

Winding, M. et al: ‘The connectome of an insect brain.’ Science, 10 March 2023. DOI: 10.1126/science.add9330 

In spring, female mussels were seen moving to the water’s edge and anchoring into the riverbed, with their back ends raised above the waterline.

Then they squirted out regular water jets, which landed in the water up to a metre away. Squirting cycles lasted 3-6 hours.

This behaviour has never been seen in any other mussel species.

The jets disturb the river surface and attract fish. Mussel larvae in the jets can then attach to the gills of the fish and complete their metamorphosis into adults.

“Who'd have thought that a mussel, that doesn't even have a head or a brain, knows to move to the river margin and squirt jets of water back into the river during springtime? It’s amazing!” said Professor David Aldridge in the University of Cambridge’s Department of Zoology, lead author of the report published today in the journal Ecology.

Unlike other mussel species, Unio crassus has a limited range of suitable host fishes – including minnows and chub. These species were attracted to the falling water jets.

The researchers think the mussels squirt water jets to increase the chances of their larvae attaching to the right host fishes. By being squirted into the air and not the water, the larvae are propelled greater distances from the parent mussel.

The study was carried out during spring in the Biała Tarnowska River, Poland. Six squirts were collected from each mussel for analysis – which confirmed that they contained viable mussel larvae.

Before now, there was only anecdotal evidence of this behaviour. Some scientists thought the water jets might be a way for the mussels to expel faeces.

This behaviour could explain why Unio crassus is an endangered species. Climbing out of the water to squirt makes it vulnerable to floods, destruction of river margins, and predators like mink. And its need for specific host fishes links its survival to theirs.

Understanding how this species completes its life cycle is important for its conservation under changing environmental conditions.

Reference

Aldridge, D. C. et al: Fishing for hosts: larval spurting by the endangered thick-shelled river mussel, Unio crassus. Ecology, March 2023. DOI: 10.1002/ECY.4026 

Cambridge University Association Football Club (CUAFC) will wear an innovatively recycled football kit for the 37th Women’s Varsity Match and the 138th Men’s Varsity Match against Oxford University on Sunday 19th March.

The kits include shirts, shorts and socks made from OEKO-TEX certified recycled yarn, produced by recycling used plastic bottles. At the Varsity matches, CUAFC are wearing the equivalent of 2,500 plastic 0.5 litre bottles, approximately 30 bottles per player.

To produce the kits, post-consumer PET plastic bottles are first shredded into small pieces in a recycling plant and cleaned. The parts are melted and the resulting mass is pressed into the desired shape by extrusion. From this the yarn is produced and further processed into fabric which is used to make clothing. The result: Kits made entirely from plastic bottles. 

Matt Hawthorn, captain of the men's team, studying Land Economy at Pembroke College says: “We are proud, as the oldest football club in the world, to lead the way on sustainability in Cambridge sport by choosing kits made from recycled plastic bottles. As sports teams typically need to order new kits for each season and for the Varsity matches, this is a first step towards reducing our environmental footprint.”

Fran Steele, captain of the women’s team, studying Medicine at Wolfson College says: “CUAFC is incredibly excited to be wearing a sustainable kit at the Varsity Match 2023. As a club, we are proud to promote the use of recyclable sports kits, which can help to raise awareness about environmental issues and encourage others to adopt more sustainable practices. The use of this sports kit for this large event is a small but impactful way to contribute to a more sustainable and environmentally-conscious future.”

The kits have been developed by Appareal, a Swiss-based company whose mission is to provide sustainable clothing from recycled sources. It was co-founded four years ago by Andy Wright, who took up studying an Mst at Selwyn College in 2022. Having read the College’s Sustainability Charter, Mr Wright saw an opportunity to expand it through the use of sustainable sports clothing.

The men's and women's Varsity matches against Oxford University will take place on the 19th of March at the Breyer Group Stadium in Leyton, East London, home to League 2 leaders Leyton Orient. Tickets can be bought on the Leyton Orient website.

The University of Cambridge was one of 27 Privileged Bodies – institutions and corporations that enjoy the historic right to present these to the Sovereign – presenting an Address. The Acting Vice-Chancellor introduced and delivered the text of the University’s Address to His Majesty, highlighting the role of the late Prince Philip, Duke of Edinburgh, as the University's Chancellor for thirty-five years, and mentioning members of the Royal Family who are alumni, including the King.

In accordance with University regulations, the Acting Vice-Chancellor was accompanied by the Registrary and the Proctors. He was joined by other members of the University specially nominated for this occasion: the Master of Jesus College, the President of the Postdocs of Cambridge Society and the Presidents (Postgraduate and Undergraduate) of the University of Cambridge Students’ Union. The Esquire Bedells and the University Marshal also attended.

Responding to the Privileged Bodies, HM The King remarked: “Whether in the fields of education, science, or the arts, or whether as representatives of the faith communities or of civic organisations, you advance our knowledge and our understanding of how we relate to each other and the world about us. You underpin the very foundations upon which our country is built and help to construct a framework of excellence and achievement within which our civil society functions and our national narrative can be formed.”

The last time the University was invited to deliver a Loyal Address was in 2012, on the occasion of the Diamond Jubilee of Her Majesty Queen Elizabeth II.

The Cambridge Bursary Scheme is available to students with residual household incomes up to £62,215. But we understand that there are further pressures impacting students and their families, so we have increased responsive funding for students who are experiencing financial hardship. Across the colleges and the University, a further £4.5m has been allocated for support in the current academic year, to benefit all students (undergraduate and postgraduate).

The University and colleges are introducing other measures, including subsidising the cost of food, such as at the University’s West Hub, and fixed price meals at a number of colleges. College rent increases have also been kept at below inflation rates, with student input into these decisions.

We also continue to monitor increases in the cost of living, and are actively considering ways to improve future support for students who are most likely to be impacted.

We will continue to work closely with the Russell Group and others to raise the issue of student support at government level.

We encourage any student who is struggling with the cost of living to speak to their college and access support.

Team AlgaeSorb’s winning pitch persuaded a panel of innovation experts to award them the top prize of £1500 for an idea, which judge Dr Nicky Dee, Founder of climate-focused venture capital group Carbon13, described as “elegant”. 

“The Climate Challenge was an incredible opportunity to not only meet like-minded students, but learn invaluable skills on crafting and designing impact-driven projects,” said Team AlgaeSorb’s Anish Chaluvadi, a Gates-Cambridge Scholar and Nanoscience and Nanotechnology PhD student at King’s College. 

The team also includes Nanoscience and Nanotechnology PhD student Timothy Lambden (Girton College) and Tristan Spreng, a Natural Sciences Masters’ student (Trinity College) and President of the Cambridge University Energy Technology Society. 

“The Climate Challenge was one of the most exciting and well-organised events I got to attend during my four years at Cambridge," Spreng said. "From the breadth of speakers at the seminar sessions to exchanging ideas with other participants during the launch and final events, it was a truly amazing experience.” 

Eight teams gathered in the Cambridge Institute for Sustainability Leadership’s (CISL) newly retro-fitted Entopia building to pitch ideas ranging from using machine learning to create algorithms for flood risk to crunching satellite data for locating wall-mounted solar panels. 

The judging panel also included serial entrepreneur Simon Hombersley, Professor Jaideep Prabhu, the Jawaharlal Nehru Professor of Indian Business and Enterprise at the Cambridge Judge Business School, Lindsay Hooper, Executive Director of CISL and Chris Gibbs from the University’s technology transfer unit Cambridge Enterprise.  

Dr Dee said AlgaeSorb was a brilliant entry by a mixed team, which drew on different country experiences and expertise across chemistry, physics and materials sciences. 

“As a result they developed an elegant solution to tackle methane in the Global South where other landfill solutions are not available and in a way that supports the local communities,” she said. 

In between pitches, experts such as Professor Prabhu and Cambridge Zero Director Professor Emily Shuckburgh offered insights on sustainable innovation and its importance in the race to reduce greenhouse gas emissions and keep global temperatures below 1.5 degrees Celsius.

Dr Amy Munro-Faure, Cambridge Zero’s Head of Education and Student Engagement led a quick game that mixed teams for spontaneous pitches, which resulted in a wild melange of ideas that included saving dolphins and travelling through time. 

The eight-week Climate Challenge programme is run in partnership with CISL Canopy, Carbon13, Energy IRC, Cambridge Enterprise, the Maxwell Centre and sponsored by Moda Living. Competing teams undertake training and develop early-stage proposals for solutions to tackle climate challenges in innovative ways.  

Each year there is a new theme. This year’s theme, “A Just Transition”, asked teams to consider the social impacts of their climate solutions.  

Two runner-up teams were awarded a prize of £750. FireSight, formed of Jovana Knezevic and Onkar Gulati, pitched a risk assessment and consulting service to address global wildfires using remote sensing and machine learning. Carolina Pulignani and Shannon A. Bonke of Wastevalor fascinated the judges with their technology that converts waste into methanol.  

Team Reckon, made up of Aparna Holenarasipura Sreedhara and Akanksha Sahay, won the Audience Choice Award for their software as a service platform entry. The software gives organisations the ability to measure the social impact of their climate transition plans.

Judges said the Climate Challenge was a powerful demonstration of how innovation and the determination to tackle climate change permeate every level of the Cambridge University community.  

“Helping build the entrepreneurial mindset in the University ecosystem is critical to the innovation agenda and particularly crucial for a true net zero where over half the innovations needed for 2050 are still in the lab,” Gibbs said.

Researchers from the University of Cambridge conducted a study in a tech consultancy firm using two robot wellbeing coaches, where 26 employees participated in weekly robot-led wellbeing sessions for four weeks. Although the robots had identical voices, facial expressions, and scripts for the sessions, the physical appearance of the robot affected how participants interacted with it.

Participants who did their wellbeing exercises with a toy-like robot said that they felt more of a connection with their ‘coach’ than participants who worked with a humanoid-like robot. The researchers say that perception of robots is affected by popular culture, where the only limit on what robots can do is the imagination. When faced with a robot in the real world however, it often does not live up to expectations.

Since the toy-like robot looks simpler, participants may have had lower expectations and ended up finding the robot easier to talk and connect with. Participants who worked with the humanoid robot found that their expectations didn’t match reality, since the robot was not capable of having interactive conversations.

Despite the differences between expectations and reality, the researchers say that their study shows that robots can be a useful tool to promote mental wellbeing in the workplace. The results will be reported today (15 March) at the ACM/IEEE International Conference on Human-Robot Interaction in Stockholm.

The World Health Organization recommends that employers take action to promote and protect mental wellbeing at work, but the implementation of wellbeing practices is often limited by a lack of resources and personnel. Robots have shown some early promise for helping address this gap, but most studies on robots and wellbeing have been conducted in a laboratory setting.

“We wanted to take the robots out of the lab and study how they might be useful in the real world,” said first author Dr Micol Spitale, from Cambridge’s Department of Computer Science and Technology.

The researchers collaborated with local technology company Cambridge Consultants to design and implement a workplace wellbeing programme using robots. Over the course of four weeks, employees were guided through four different wellbeing exercises by one of two robots: either the QTRobot (QT) or the Misty II robot (Misty).

The QT is a childlike humanoid robot and roughly 90cm tall, while Misty is a 36cm tall toy-like robot. Both robots have screen faces that can be programmed with different facial expressions.

“We interviewed different wellbeing coaches and then we programmed our robots to have a coach-like personality, with high openness and conscientiousness,” said co-author Minja Axelsson. “The robots were programmed to have the same personality, the same facial expressions and the same voice, so the only difference between them was the physical robot form.”

Participants in the experiment were guided through different positive psychology exercises by a robot in an office meeting room. Each session started with the robot asking participants to recall a positive experience or describe something in their lives they were grateful for, and the robot would ask follow-up questions. After the sessions, participants were asked to assess the robot with a questionnaire and an interview. Participants did one session per week for four weeks, and worked with the same robot for each session.

Participants who worked with the toy-like Misty robot reported that they had a better working connection with the robot than participants who worked with the child-like QT robot. Participants also had a more positive perception of Misty overall.

“It could be that since the Misty robot is more toy-like, it matched their expectations,” said Spitale. “But since QT is more humanoid, they expected it to behave like a human, which may be why participants who worked with QT were slightly underwhelmed.”

“The most common response we had from participants was that their expectations of the robot didn’t match with reality,” said Professor Hatice Gunes, who led the research. “We programmed the robots with a script, but participants were hoping there would be more interactivity. It’s incredibly difficult to create a robot that’s capable of natural conversation. New developments in large language models could really be beneficial in this respect.”

“Our perceptions of how robots should look or behave might be holding back the uptake of robotics in areas where they can be useful,” said Axelsson.

Although the robots used in the experiment are not as advanced as C-3PO or other fictional robots, participants still said they found the wellbeing exercises helpful, and that they were open to the idea of talking to a robot in future.

“The robot can serve as a physical reminder to commit to the practice of wellbeing exercises,” said Gunes. “And just saying things out loud, even to a robot, can be helpful when you’re trying to improve mental wellbeing.”

The team is now working to enhance the robot coaches’ responsiveness during coaching practices and interactions.

The research was supported by the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI). Hatice Gunes is a Staff Fellow of Trinity Hall, Cambridge.

Reference:
Micol Spitale, Minja Axelsson, and Hatice Gunes. ‘Robotic Mental Well-being Coaches for the Workplace: An In-the-Wild Study on Form.’ Paper presented to the ACM/IEEE International Conference on Human-Robot Interaction, Stockholm, Sweden, 13-16 March 2023.

Try a positive psychology session with the robots used in this research as part of the Cambridge Festival on Saturday, 18 March. 

Scientists from the University of Cambridge now have a way to estimate how much water a rocky planet can store in its subterranean reservoirs. It is thought that this water, which is locked into the structure of minerals deep down, might help a planet recover from its initial fiery birth.

The researchers developed a model that can predict the proportion of water-rich minerals inside a planet. These minerals act like a sponge, soaking up water which can later return to the surface and replenish oceans. Their results could help us understand how planets can become habitable following intense heat and radiation during their early years.

Planets orbiting M-type red dwarf stars — the most common star in the galaxy — are thought to be one of the best places to look for alien life. But these stars have particularly tempestuous adolescent years — releasing intense bursts of radiation that blast nearby planets and bake off their surface water.

Our Sun’s adolescent phase was relatively short, but red dwarf stars spend much longer in this angsty transitional period. As a result, the planets under their wing suffer a runaway greenhouse effect where their climate is thrown into chaos. 

“We wanted to investigate whether these planets, after such a tumultuous upbringing, could rehabilitate themselves and go on to host surface water,” said lead author of the study, Claire Guimond, a PhD student in Cambridge’s Department of Earth Sciences.

The new research, published in the Monthly Notices of the Royal Astronomical Society, shows that interior water could be a viable way to replenish liquid surface water once a planet’s host star has matured and dimmed. This water would likely have been brought up by volcanoes and gradually released as steam into the atmosphere, together with other life-giving elements.

Their new model allows them to calculate a planet’s interior water capacity based on its size and the chemistry of its host star. “The model gives us an upper limit on how much water a planet could carry at depth, based on these minerals and their ability to take water into their structure,” said Guimond.

The researchers found that the size of a planet plays a key role in deciding how much water it can hold. That’s because a planet’s size determines the proportion of water-carrying minerals it is made of.

Most of a planet’s interior water is contained within a rocky layer known as the upper mantle — which lies directly below the crust. Here, pressure and temperature conditions are just right for the formation of green-blue minerals called wadsleyite and ringwoodite that can soak up water. This rocky layer is also within reach of volcanoes, which could bring water back to the surface through eruptions.

The new research showed that larger planets — around two to three times bigger than Earth — typically have drier rocky mantles because the water-rich upper mantle makes up a smaller proportion of their total mass.

The results could provide scientists with guidelines to aid their search for exoplanets that might host life, “This could help refine our triaging of which planets to study first,” said Oliver Shorttle, who is jointly affiliated with Cambridge’s Department of Earth Sciences and Institute of Astronomy. “When we’re looking for the planets that can best hold water you probably do not want one significantly more massive or wildly smaller than Earth.”

The findings could also add to our understanding of how planets, including those closer to home like Venus, can transition from barren hellscapes to a blue marble. Temperatures on the surface of Venus, which is of a similar size and bulk composition to Earth, hover around 450oC and its atmosphere is heavy with carbon dioxide and nitrogen. It remains an open question whether Venus hosted liquid water at its surface 4 billion years ago.  “If that’s the case, then Venus must have found a way to cool itself and regain surface water after being born around a fiery sun,” said Shorttle, “It’s possible that it tapped into its interior water in order to do this.”

Reference:
Guimond, C. M., Shorttle, O., & Rudge, J. F. 'Mantle mineralogy limits to rocky planet water inventories'. Monthly Notices of the Royal Astronomical Society (2023). DOI: 10.1093/mnras/stad148

The organs are kept functioning by restarting local circulation to the heart, lungs and abdominal organs – but, crucially, not to the brain – of patients whose hearts have stopped beating for five minutes or longer and have been declared dead by circulatory criteria (donation after circulatory death, or DCD).

It is hoped that this technique could increase the number of usable donated hearts by as much as 30% in the future, helping address the shortage of transplant organs. In 2021, 8,409 heart transplants were reported to the Global Observatory on Donation and Transplantation (GODT) by 54 countries. This activity is in contrast with the 21,935 patients who were on a heart waiting list during the year 2021, of whom 1,511 died while waiting and many others became too sick to receive a transplant.

John Louca, a final year medical student at Gonville & Caius College, University of Cambridge, and the study’s first author, said: “Heart transplants are the last bastion for patients with end-stage heart failure. They are successful – patients who receive a transplant live on average a further 13 to 16 years. The biggest problem they face is actually getting access to a donated heart: many patients will die before an organ becomes available. That’s why we urgently need to find ways to increase the suitability of donor organs.”

Though the first heart transplant performed at the Groote Schuur Hospital in Cape Town (South Africa) in 1967 was obtained from a DCD donor, this technique was abandoned and replaced by heart transplants obtained from donors confirmed dead using neurological criteria (donation after brain death, or DBD) – in other words, their brain has stopped functioning entirely.

Until recently, heart transplants worldwide were still performed only with organs obtained from DBD donors. However, in recent years, heart transplants from DCD donors have become a clinical reality worldwide thanks to years of research carried out in Cambridge.

DCD is the donation of organs by patients who tragically have a non-survivable illness. These patients are typically unconscious in intensive care in hospital and dependent on ventilation. Detailed discussions between doctors, specialist nurses and the patient’s family take place and if the family agree to organ donation, the process starts.

After treatment is withdrawn, the heart stops beating and it begins to sustain damage to its tissues. After 30 minutes, it is thought that this damage becomes irreversible and the heart unusable. To prevent this damage, at the time of death these non-beating hearts are transferred to a portable machine known as the Organ Care System (OCS) where the organ is perfused with oxygenated blood and assessed to see whether it is suitable for transplantation.

This technique was pioneered by Royal Papworth Hospital NHS Foundation Trust in Cambridge, whose transplant team carried out the first DCD heart transplant in Europe in 2015. Royal Papworth has since become the largest and most experienced DCD heart transplant centre in the world.

DCD heart transplantation started simultaneously in Australia, followed by Belgium, The Netherlands, Spain and USA. According to the GODT, 295 DCD heart transplants were performed in these six countries in 2021.

Organ Care Systems are expensive, costing around US$400,000 per machine plus an additional $75,000 for consumables for each perfused organ. An alternative, and much more cost-effective approach, is known as thoraco-abdominal normothermic reperfusion (taNRP). This involves perfusing the organ in situ in the donor’s body and is estimated to cost around $3,000. Its use was first reported in 2016 by a team at Royal Papworth Hospital.

In a study published in eClinical Medicine, an international team of clinical scientists and heart specialists from 15 major transplant centres worldwide, including the UK, Spain, the USA and Belgium, looked at clinical outcomes of 157 DCD donor hearts recovered and transplanted from donors undergoing taNRP. They compared these with the outcomes from 673 DBD heart transplants, which represents the ‘gold-standard’.

The team found that overall, the use of taNRP increased the donor pool significantly, increasing the number of heart transplantations performed by 23%.

Mr Stephen Large, Consultant Cardiothoracic Surgeon at Royal Papworth Hospital and chief investigator, said: “Withdrawing life support from a patient is a difficult decision for both the families and medical staff involved and we have a duty to honour the wishes of the donor as best we can. At present, one in ten retrieved hearts is turned down, but restoring function of the heart in situ could help us ensure more donor hearts find a recipient.”

Survival rates were comparable between DCD and DBD heart transplantation, with 97% of patients surviving for more than 30 days following taNRP DCD heart transplant, 93% for more than a year and 84% of patients still alive after five years.

Professor Filip Rega, Head of Clinic at the Department of Cardiac Surgery, UZ Leuven, Belgium, said: “This promising new approach will allow us to offer heart transplantation, a last resort treatment, to many more patients in need of a new heart.”

The researchers say that some of the benefits from taNRP are likely thanks to the reduced amount of time the heart was not receiving oxygenated blood, known as its warm ischaemic time, when compared to direct procurement (that is, when the heart is removed immediately for transplant, and perfused outside the body). The median average time was 16.7 minutes, significantly less than the 30 minutes associated with permanent damage to the heart cells.

An added benefit to this approach is that it allows medical teams to simultaneously preserve several organs, such as the liver, pancreas and kidneys, without the need of several organ-specific external machine perfusion devices. This decreases complexity and costs.

Professor Ashish Shah, Head of the Department of Cardiac Surgery at Vanderbilt University Hospitals, Nashville, USA, said: “Heart transplantation has been and always will be a uniquely international effort. The current study is another example of effective international collaboration and opens a new frontier, not just in transplantation, but in our basic understanding of how all hearts can be rescued.”

Dr Beatriz Domínguez-Gil, Director General of the National Organisation of Transplantation in Spain, said: “The results of this collaborative study bring hope to thousands of patients in need for a heart transplant every year throughout the world. Its findings reveal that DCD heart transplantation based on taNRP can lead to results at least similar to the gold standard and increase hearts available for transplantation in a manner that contributes to the sustainability of health-care systems.”

Reference
Louca, J et al. The international experience of in-situ recovery of the DCD heart: A multicentre retrospective observational study. eClin Med; published online 2 March 2023; DOI: 10.1016/j.eclinm.2023.101887

An international team of researchers, led by the University of Cambridge, the University of Oxford, and the University of California San Diego, quantified the effect of these waves and other forms of underwater turbulence in the Atlantic Ocean and found that their importance is not being accurately reflected in the climate models that inform government policy.

Most of the heat and carbon emitted by human activity is absorbed by the ocean, but how much it can absorb is dependent on turbulence in the ocean’s interior, as heat and carbon are either pushed deep into the ocean or pulled toward the surface.

While these underwater waves are already well-known, their importance in heat and carbon transport is not fully understood.

The results, reported in the journal AGU Advances, show that turbulence in the interior of oceans is more important for the transport of carbon and heat on a global scale than had been previously imagined.

Ocean circulation carries warm waters from the tropics to the North Atlantic, where they cool, sink, and return southwards in the deep ocean, like a giant conveyer belt. The Atlantic branch of this circulation pattern, called the Atlantic Meridional Overturning Circulation (AMOC), plays a key role in regulating global heat and carbon budgets. Ocean circulation redistributes heat to the polar regions, where it melts ice, and carbon to the deep ocean, where it can be stored for thousands of years.

“If you were to take a picture of the ocean interior, you would see a lot of complex dynamics at work,” said first author Dr Laura Cimoli from Cambridge’s Department of Applied Mathematics and Theoretical Physics. “Beneath the surface of the water, there are jets, currents, and waves – in the deep ocean, these waves can be up to 500 metres high, but they break just like a wave on a beach.”

“The Atlantic Ocean is special in how it affects the global climate,” said co-author Dr Ali Mashayek from Cambridge’s Department of Earth Sciences. “It has a strong pole-to-pole circulation from its upper reaches to the deep ocean. The water also moves faster at the surface than it does in the deep ocean.”

Over the past several decades, researchers have been investigating whether the AMOC may be a factor in why the Arctic has lost so much ice cover, while some Antarctic ice sheets are growing. One possible explanation for this phenomenon is that heat absorbed by the ocean in the North Atlantic takes several hundred years to reach the Antarctic.

Now, using a combination of remote sensing, ship-based measurements and data from autonomous floats, the Cambridge-led researchers have found that heat from the North Atlantic can reach the Antarctic much faster than previously thought. In addition, turbulence within the ocean – in particular large underwater waves – plays an important role in the climate.

Like a giant cake, the ocean is made up of different layers, with colder, denser water at the bottom, and warmer, lighter water at the top. Most heat and carbon transport within the ocean happens within a particular layer, but heat and carbon can also move between density layers, bringing deep waters back to the surface.

The researchers found that the movement of heat and carbon between layers is facilitated by small-scale turbulence, a phenomenon not fully represented in climate models.

Estimates of mixing from different observational platforms showed evidence of small-scale turbulence in the upper branch of circulation, in agreement with theoretical predictions of oceanic internal waves. The different estimates showed that turbulence mostly affects the class of density layers associated with the core of the deep waters moving southward from the North Atlantic to the Southern Ocean. This means that the heat and carbon carried by these water masses have a high chance of being moved across different density levels.

“Climate models do account for turbulence, but mostly in how it affects ocean circulation,” said Cimoli. “But we’ve found that turbulence is vital in its own right, and plays a key role in how much carbon and heat gets absorbed by the ocean, and where it gets stored.”

“Many climate models have an overly simplistic representation of the role of micro-scale turbulence, but we’ve shown it’s significant and should be treated with more care,” said Mashayek. “For example, turbulence and its role in ocean circulation exerts a control over how much anthropogenic heat reaches the Antarctic Ice Sheet, and the timescale on which that happens.”

The research suggests an urgent need for the instalment of turbulence sensors on global observational arrays and a more accurate representation of small-scale turbulence in climate models, to enable scientists to make more accurate projections of the future effects of climate change.

The research was supported in part by the Natural Environment Research Council (NERC), part of UK Research and Innovation (UKRI).

Reference:
Laura Cimoli et al. ‘Significance of Diapycnal Mixing Within the Atlantic Meridional Overturning Circulation.’ AGU Advances (2023). DOI: 10.1029/2022AV000800

Scientists at the Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID) and Wellcome Sanger Institute showed that following SARS-CoV-2 infection, cells in the lining of the lungs, nasal cells, and immune cells in the blood show a blunted inflammatory response in obese patients, producing suboptimal levels of molecules needed to fight the infection.

Since the start of the pandemic, there have been almost 760 million confirmed cases of SARS-CoV-2 infection, with almost 6.9 million deaths. While some people have very mild – or even no – symptoms, others have much more severe symptoms, including acute respiratory distress syndrome requiring ventilator support.

One of the major risk factors for severe COVID-19 is obesity, which is defined as a body mass index (BMI) of over 30. More than 40% of US adults and 28% of adults in England are classed as obese.

While this link has been shown in numerous epidemiological studies, until now, it has not been clear why obesity should increase an individual’s risk of severe COVID-19. One possible explanation was thought to be that obesity is linked to inflammation: studies have shown that people who are obese already have higher levels of key molecules associated with inflammation in their blood. Could an overactive inflammatory response explain the connection?

Professor Menna Clatworthy is a clinician scientist at the University of Cambridge, studying tissue immune cells at CITIID alongside caring for patients at Addenbrooke’s Hospital, part of Cambridge University Hospitals NHS Foundation Trust. She said: “During the pandemic, the majority of younger patients I saw on the COVID wards were obese. Given what we know about obesity, if you’d asked me why this was the case, I would have said that it was most likely due to excessive inflammation. What we found was the absolute opposite.”

Clatworthy and her team analysed blood and lung samples taken from 13 obese patients with severe COVID-19 requiring mechanical ventilation and intensive care treatment, and 20 controls (non-obese COVID-19 patients and ventilated non-COVID-19 patients). These included patients admitted to the Intensive Care Unit at Addenbrooke’s Hospital.

Her team used a technique known as transcriptomics, which looks at RNA molecules produced by our DNA, to study activity of cells in these key tissues. Their results are published in the American Journal of Respiratory and Critical Care Medicine.

Contrary to expectations, the researchers found that the obese patients had underactive immune and inflammatory responses in their lungs.  In particular, when compared to non-obese patients, cells in the lining of their lungs and some of their immune cells had lower levels of activity among genes responsible for the production of two molecules known as interferons (INF) – interferon-alpha and interferon-gamma – which help control the response of the immune system, and of tumour necrosis factor (TNF), which causes inflammation.

When they looked at immune cells in the blood of 42 adults from an independent cohort, they found a similar, but less marked, reduction in the activity of interferon-producing genes as well as lower levels of IFN-alpha in the blood.

Professor Clatworthy said: “This was really surprising and unexpected. Across every cell type we looked at, we found that that the genes responsible for the classical antiviral response were less active. They were completely muted.”

The team was able to replicate its findings in nasal immune cells taken from obese children with COVID-19, where they again found lower levels of activity among the genes that produce IFN-alpha and IFN-gamma. This is important because the nose is one of the entry points for the virus – a robust immune response there could prevent the infection spreading further into the body, while a poorer response would be less effective.

One possible explanation for the finding involves leptin, a hormone produced in fat cells that controls appetite. Leptin also plays a role in the immune response: in individuals who are normal weight, levels of the hormone increase in response to infection and it directly stimulates immune cells. But obese people already have chronically higher levels of leptin, and Clatworthy says it is possible that they no longer produce sufficient additional leptin in response to infection, or are insensitive to it, leading to inadequate stimulation of their immune cells.

The findings could have important implications both for the treatment of COVID-19 and in the design of clinical trials to test new treatments.

Because an overactive immune and inflammatory response can be associated with severe COVID-19 in some patients, doctors have turned to anti-inflammatory drugs to dampen this response. But anti-inflammatory drugs may not be appropriate for obese patients.

Co-author Dr Andrew Conway Morris from the Department of Medicine at the University of Cambridge and Honorary Consultant on the intensive care unit at Addenbrooke’s Hospital said: “What we’ve shown is that not all patients are the same, so we might need to tailor treatments. Obese subjects might need less anti-inflammatory treatments and potentially more help for their immune system.”

Clinical trials for potential new treatments would need to involve stratifying patients rather than including both severe and normal weight patients, whose immune responses differ.

The research was largely supported by Wellcome, the Medical Research Council and the National Institute of Health and Care Research, including via the NIHR Cambridge Biomedical Research Centre.

Reference
Guo, SA, Bowyer, GS, Ferdinand, JR, Maes, M & Tuong, ZK et al. Obesity associated with attenuated tissue immune cell responses in COVID-19. Am J Resp Critical Care Med; 1 Mar 2023; DOI: 10.1164/rccm.202204-0751OC 

The first Innovate UK award, received in 2021, allowed SMi to partner with the Cambridge Institute of Therapeutic Immunology and Infectious Disease, the Medicines Discovery Catapult and the National Physical Laboratory to develop its technology for testing for respiratory diseases. The second award, made in early 2023, is helping SMi and its partners apply the same technology to detecting cancer.

Co-founded in 2018 by former University of Cambridge researcher Dr Andrew Thompson, SMi is developing a new technology that analyses samples using super-resolution imaging. The technology can detect, quantify and characterise single molecules that are of interest, including DNA, RNA and protein molecules associated with specific diseases. It can visualise what other technologies cannot see and very rapidly batch analyse hundreds of samples with extremely high accuracy.

The first round of £1.9m funding enabled SMi to develop its platform, used for the simultaneous screening of common respiratory diseases. The COVID-19 pandemic demonstrated the need for rapid and cost-effective diagnostic testing on a massive scale. Test accuracy and the ability to identify new variants were critical.

The second Innovate UK award has funded the application of SMi’s platform to cancer diagnosis by enabling work with another team of specialists at the Medicines Discovery Catapult. Here the same single molecule visualisation approach is being used to detect and quantify cancer biomarkers in patient blood samples. This will help clinicians to make more accurate assessments, and combined with the flexibility, accuracy, speed and high throughput of SMi’s technology, could reduce diagnostic backlogs and provide patients with their results much sooner.

SMi’s aim has always been to create a user-friendly, automated benchtop instrument that can be used in both research and healthcare settings. Initial instrument designs were guided by consultation with NHS trusts and the NIHR Medical Devices Testing and Evaluation Centre (MD-TEC), while prototypes have been tested in labs at the University of Cambridge, the Medicines Discovery Catapult and the National Physical Laboratory. Commercial production will be outsourced to a medical device manufacturer in the East of England.

SMi’s CEO Dr Andrew Thompson said: “SMi is creating a highly accurate and user-friendly platform that is based upon single molecule imaging, meaning that we can detect individual molecules that are invisible to other technologies. With an approach that allows them to reliably monitor single molecules, SMi provides scientists and clinicians with a quality of data that is unprecedented. Such capabilities are likely to have far-reaching benefits for diagnosis and the discovery of new medicines. Our Innovate UK funding is allowing us to work with very highly qualified research and clinical partners, providing a means to accelerate our product development and realise these opportunities sooner.”

The Cambridge Institute for Therapeutic Immunology and Infectious Diseases has been leading the University of Cambridge’s collaboration with SMi. Ravindra Gupta, Professor of Clinical Microbiology, and named as one of Time Magazine’s 100 most influential people of the year in 2020 for his work on HIV, said: “SMi’s platform is incredibly exciting and could revolutionise testing for a range of diseases. We have been fortunate to partner with SMi on SARS-CoV-2 detection, and application could extend to identification of specific genetic variants of pathogens as well as cancers.”

Dr Tammy Dougan, Life Science and Healthcare Partnership Lead in the University’s Strategic Partnerships Office, said: “This is a great example of a Cambridge start-up winning Innovate UK funding and using it to build effective collaborations between research partners to take a new technology out of the lab and into clinical practice.”

Since 2018, SMi has grown into a team of sixteen, including scientists, mechanical engineers, software engineers and medical device specialists based in two locations: the outskirts of Cambridge and the West Coast of the USA.

The event was an opportunity to showcase this impressive contribution to the UK economy to Parliamentarians and policy makers. It was also a chance to discuss how elements of Cambridge's strategic success may be implemented in new and emerging clusters across the UK.

A highlight of the evening was George Freeman MP, the current Minister of State for Science, Innovation and Technology, delivering a very well received speech on the importance of Cambridge as the "golden corner of the golden triangle". The Minister expressed his delight at receiving such a short, focused summary report and spoke of the importance of the continued success of Cambridge for both the East of England and wider UK economy. 

The Member of Parliament for Cambridge, Daniel Zeichner MP, offered thoughts on infrastructure issues in the city that, if solved, would unlock further potential for economic growth, including tackling congestion, seeing progress on East West Rail, and finding solutions to the lack of lab space. He also described how centres of excellence, like Cambridge, need to be nurtured and supported by government policy, including targeted funding to incentivise innovation. The report had immediate impact when Daniel mentioned the results of the analysis in the House of Commons budget debate that he returned to immediately after the event.

Baroness Sally Morgan of Huyton, Master at Fitzwilliam, and who kindly sponsored the event, highlighted the finding, that for every £1 the University spends, it creates £11.70 of economic impact.

Professor Andy Neely closed the speeches, restating the headline findings and highlighting the ways in which government policy could support the ecosystem’s continued success and help Cambridge attract the best global talent.  

We were delighted to host local stakeholders, including representatives from Nyobolt, Abcam and Cambridge Enterprise, who were on hand to answer questions on how and why the University was crucial to their success. 

Attendees from Parliament included former Universities Minister and Chair of Innovate Cambridge, Lord David Willetts and former Chancellor, Lord Norman Lamont. From the Commons, Chi Onwurah MP (Shadow Science Minister) and Seema Malhotra MP, also joined us for the event.