A study tracking the lives of Chicagoans from childhood and adolescence in the 1990s to the start of middle age has found that 56% of Black and Hispanic residents from across the city witnessed at least one shooting by the time they turned forty.

White residents were exposed to gun violence at less than half the rate of Black and Hispanic residents, although it was still high: 25% of White Chicagoans had witnessed a shooting before turning forty.  

Across racial categories, 50% of all the study’s participants had been exposed to gun violence by age forty. The average age to witness a shooting was just 14 years old.  

Of those in the study, more than 7% of Black and Hispanic people had themselves been shot before turning forty, compared to 3% of White people. The average age for being shot was 17 years old.

Researchers also compared the locations of gun violence incidents* in the year leading up to recent study interviews in 2021. Rates of shootings within a 250-metre radius of the homes of Black participants were over 12 times higher than those of White participants. Rates of shootings near the homes of Hispanic people were almost four times higher than for White people.

The research team continued to gather data for participants who had moved out of the city, although the vast majority of gun violence took place within Chicago. 

The sustained stress of living with the potential for gun violence likely takes a “cumulative physiological toll” on Chicago’s citizens – and people in cities across the US, argue researchers.

Findings from the latest study, led by a University of Cambridge criminologist in collaboration with researchers from Harvard and Oxford universities, are published in JAMA Network Open, a journal of the American Medical Association

“Existing evidence suggests that the long-term stress of exposure to firearm violence can contribute to everything from lower test scores for schoolkids to diminished life expectancy through heart disease,” said study lead author Dr Charles Lanfear, from the University of Cambridge’s Institute of Criminology.

“We expected levels of exposure to gun violence to be high, but not this high. Our findings are frankly startling and disturbing,” said Lanfear. “A substantial portion of Chicago’s population could be living with trauma as a result of witnessing shootings and homicides, often at a very young age.”

“It is clear that Black people in particular are often living in a very different social context, with far higher risks of seeing and becoming victims of gun violence in the streets near their homes lasting into middle age.”

The Project on Human Development in Chicago Neighborhoods (PHDCN), a Harvard University study, has followed thousands of children since they were first surveyed in the 1990s, gathering life experiences as they grow up in the city or move away. Participants are from households selected at random from a set list of eighty Chicago districts – carefully chosen to reflect Chicago’s spectrum of race and levels of social advantage, or lack thereof.   

The latest research focused on data gathered from 2,418 of participants born in the early 1980s through to the mid-1990s, equally split between men and women.**   

The oldest study participants, born in 1981, hit adolescence in the early-to-mid 1990s when lethal violence reached a peak in the US. “The nineties saw a demographic bump collide with high poverty levels and rises in gang crime resulting in part from the crack epidemic,” said Lanfear.

“However, since 2016 we have seen another surge in gun violence. Rates of fatal shootings in Chicago are now higher than they ever were in the nineties.”

Men are far more likely to be involved in violent crime, and this is reflected in the risks of actually being shot by age 40, which are five times higher for men than women. However, there was a much smaller difference between the sexes for exposure to gun violence: 43% of women and 58% of men had seen someone shot.

“The chronic stress effects on women from being so highly exposed to firearm violence may well be substantial in Chicago, and indeed in many US cities,” said Lanfear.

“The study participants are taken from right across Chicago, and only a tiny fraction will be involved in any kind of crime. Given the levels of women and children witnessing gun violence in the city, the vast majority of this exposure will be as bystanders in public spaces, in streets or outside schools.”    

“The public health consequences of life in violent and traumatised neighbourhoods will be playing out not just in Chicago, but in many cities right across the United States,” Lanfear said.

The Royal Society is a self-governing Fellowship of many of the world’s most distinguished scientists drawn from all areas of science, engineering and medicine.

The Society’s fundamental purpose, as it has been since its foundation in 1660, is to recognise, promote and support excellence in science and to encourage the development and use of science for the benefit of humanity.

This year, a total of 80 researchers, innovators and communicators from around the world have been elected as Fellows of the Royal Society for their substantial contribution to the advancement of science. These include 59 Fellows, 19 Foreign Members and two Honorary Fellows.

Sir Adrian Smith, President of the Royal Society said: “I am delighted to welcome our newest cohort of Fellows. These individuals have pushed forward the boundaries of their respective fields and had a beneficial influence on the world beyond. This year’s intake have already achieved incredible things, and I have no doubt that they will continue to do so. I look forward to meeting them and following their contributions in future.” 

The Fellows and Foreign Members join the ranks of Stephen Hawking, Isaac Newton, Charles Darwin, Albert Einstein, Lise Meitner, Subrahmanyan Chandrasekhar and Dorothy Hodgkin.

The Cambridge Fellows are:

Professor Cathie Clarke FRS

Professor of Theoretical Astrophysics, Institute of Astronomy, and Fellow of Clare College

Clarke studies astrophysical fluid dynamics, including accretion and protoplanetary discs and stellar winds. She was the first to demonstrate how protoplanetary disc formation around low-mass young stars is determined by their radiation field. In 2017 she became the first woman to be awarded the Eddington Medal by the Royal Astronomical Society and in 2022 she became director of the Institute of Astronomy.

She said: “It's a great honour to join the many Cambridge astrophysicists who have held this title. I would like to particularly pay tribute to the many junior colleagues, PhD students and postdocs who have contributed to my research.”

Professor Christopher Jiggins FRS

Professor of Evolutionary Biology (2014), Department of Zoology, and Fellow of St John's College

Jiggins studies adaption and speciation in the Lepidoptera (butterflies and moths). In particular he is interested in studying how species converge due to mimicry as a model for understanding the predictability of evolution and the genetic and ecological causes of speciation. He demonstrated the importance of hybridisation and movement of genes between species in generating novel adaptations. He also works on the agricultural pest cotton bollworm and carries out genomic studies of the insect bioconversion species, black soldier fly.

He said: “I am amazed and delighted to receive this honour, and would thank all the amazing students, and postdocs that I have been lucky enough to work with over the years.”

Dr Philip Jones FRS

Senior Group Leader, Wellcome Sanger Institute and Professor of Cancer Development, University of Cambridge, and Fellow of Clare College

Jones studies how normal cell behaviour is altered by mutation in aging and the earliest stages of cancer development. He focuses on normal skin and oesophagus, which become a patchwork of mutant cells by middle age. He has found that different mutations can either promote or inhibit cancer development giving hope of new ways to prevent cancer in the future. He is also a Consultant in Medical Oncology at Addenbrooke’s Hospital in Cambridge.

He said: “I am delighted to be elected to the Fellowship of the Royal Society. This honour is a tribute to the dedication of my research team and collaborators and support of my mentors and scientific colleagues over many years.”

Dr Lori Passmore FRS

Group Leader, Structural Studies Division, MRC Laboratory of Molecular Biology, and Fellow of Clare Hall

Passmore a cryo-electron microscopist and structural biologist who works at the Medical Research Council (MRC) Laboratory of Molecular Biology and at the University of Cambridge. She is known for her work on multiprotein complexes involved in gene expression and the development of new supports for cryo-EM studies. She also studies the molecular mechanisms underlying Fanconi anemia, a rare genetic disease resulting in an impaired response to DNA damage.

She said: “I am so honoured to be recognised alongside such an exceptional group of scientists. I am grateful to all the trainees, collaborators and colleagues whom I have worked with over the past years - science is truly collaborative and this is a recognition of all the courageous work of many people.”

Professor Peter Sewell FRS

Professor of Computer Science, Department of Computer Science and Technology, and Fellow of Wolfson College

Sewell’s research aims to put the engineering of the real-world computer systems that we all depend on onto better foundations, developing techniques to make systems that are better-understood, more robust and more secure. He and his group are best known for their work on the subtle relaxed-memory concurrency behaviour and detailed sequential semantics of processors and programming languages. He co-leads the CHERI cybersecurity project, for which his team have established mathematically-proven security properties of Arm's Morello industrial prototype architecture.

He said: “This honour is a testament to the work of many excellent colleagues over the years, without whom none of this would have been possible.”

Professor Ivan Smith FRS

Professor of Geometry, Centre for Mathematical Sciences, and Fellow of Caius College

Smith is a mathematician who deals with symplectic manifolds and their interaction with algebraic geometry, low-dimensional topology and dynamics. In 2007, he received the Whitehead Prize for his work in symplectic topology, highlighting the breadth of applied techniques from algebraic geometry and topology, and in 2013 the Adams Prize. 

He said: “I am surprised, delighted and hugely honoured to be elected a Fellow of the Royal Society. I’ve been very fortunate to work in a rapidly advancing field, learning it alongside many inspirational and generous collaborators, who should definitely share this recognition.”

Professor William Sutherland CBE FRS

Miriam Rothschild Chair of Conservation Biology, Department of Zoology and Professorial Fellow of St Catharine’s College

Sutherland is a conservation scientist who is interested in improving the processes by which decisions are made. This has involved horizon scanning to identify future issues to reduce the surprises of future developments. His main work has been the industrial-scale collation of evidence to determine which interventions are effective and which are not and then establishing processes for embedding evidence in decision making. He has developed a free, online resource, Conservation Evidence, summarising evidence for the effectiveness of conservation actions to support anyone making decisions about how to maintain and restore biodiversity and an open access book Transforming Conservation: a practical guide to evidence and decision making.

He said: “I am delighted that our work on the means of improving decision making in conservation and elsewhere has been recognised in this way and thank my numerous collaborators.”

A team of researchers, jointly led by the Universities of Oxford and Cambridge, have discovered that a solar cell material – bismuth oxyiodide (BiOI) – is capable of detecting X-ray dose rates over 250 times lower than the current best performing detectors used commercially. This has the potential to make medical imaging safer, and open up new opportunities in non-invasive diagnostics, such as X-ray video techniques. Their results are reported in the journal Nature Communications.

“We have developed BiOI single crystals into X-ray detectors that work over 100 times better than the current state-of-the-art for medical imaging,” said Dr Robert Hoye from the University of Oxford, who led the work. “BiOI is nontoxic, stable in air, and can be grown cost-effectively and at scale. We are very excited by the potential BiOI has to make the next generation of non-invasive diagnostics more accessible, safer, and more effective.”

BiOI is a nontoxic semiconductor that absorbs visible light and is stable in air. Owing to these qualities, over the past decade there has been a surge of interest in this material for solar cells (turning sunlight into clean electricity), photoelectrochemical cells (turning sunlight into fuels) and energy harvesting to power smart devices, among many other applications.

BiOI contains two heavy elements – bismuth and iodine – which allows the material to strongly absorb X-rays. However, previous attempts to make BiOI into X-ray detectors were ineffective due to significant energy losses from defects arising from the nanocrystalline nature of the detectors made.

The researchers developed and patented a method to grow high-quality single crystals of BiOI using a scalable vapour-based approach. The low defect density in these crystals led to stable and ultra-low dark currents, which was critical to substantially improve the sensitivity and detection limit of this material to X-rays.

“Showing that these simply-processed, low-temperature grown, stable crystals can give such high sensitivity for X-ray detection is quite remarkable,” said Professor Judith Driscoll from Cambridge’s Department of Materials Science and Metallurgy, who co-led the work. “We began working on this material, BiOI, several years ago, and we find it outshines other rival materials in a range of optoelectronic and sensing applications, when toxicity and performance are considered together.”

The researchers formed an interdisciplinary team to understand why BiOI works so well as an X-ray detector. They used advanced optical techniques to resolve processes taking place over a trillionth of a second, and coupled these with simulations to link these processes with what is happening at the atomic level.

Through this study, the team revealed the unusual way in which electrons couple to vibrations in the lattice. Unlike other bismuth-halide compounds, the electrons in BiOI remain delocalised, meaning that electrons can easily and rapidly move within the lattice of BiOI. At the same time, the unusual electron coupling with lattice vibrations results in an irreversible energy loss channel that would still be present even if the material were defect-free.

The researchers found that these losses can be overcome by cooling down the sample to reduce thermal energy, or by applying an electric field to rip away electrons from the lattice. The latter case is ideally matched with how X-ray detectors operate. By applying a small electric field, electrons can be transported over a millimetre length-scale, allowing the efficient extraction of electrons generated in the single crystals through the absorption of X-rays.

“We have built a microscopic quantum mechanical model of electrons and ions that can fully explain the remarkable optoelectronic properties of BiOI that make it such a good material for X-ray detection,” said Dr Bartomeu Monserrat from Cambridge’s Department of Materials Science and Metallurgy, who co-led the project. “This gives us a roadmap for designing even more materials with similarly advantageous properties.

This work offers important insights into how delocalised charge-carriers can be achieved in bismuth-halide compounds. The researchers are now working on applying these insights to design materials with similarly advantageous properties as BiOI, as well as how to tune the composition of BiOI to improve its transport properties further. They are also working on bringing the unique benefits of BiOI to society by devising routes to increase the size of the BiOI detectors, while preserving the exceptional properties found in single crystals.

The study also involved researchers from Imperial College London, Queen Mary University London, Technical University Munich and CNRS in Toulouse.

Reference:
R A Jagt, I Bravić, et al. ‘Layered BiOI single crystals capable of detecting low dose rates of X-rays.’ Nature Communications (2023). https://doi.org/10.1038/s41467-023-38008-4

Adapted from a story by the University of Oxford

The BUCS Outdoor Athletics Championships, held in Manchester, saw Cambridge athletes from Cambridge University Athletic Club and Cambridge University Hare and Hounds, clinch five medals. Some of the notable results included:

• Angus Harrington of St. John's College securing a gold medal in the 800m event, making him the BUCS Champion for the 2022-23 season. 
• Jeremy Dempsey from Girton College claiming the silver medal in the highly competitive 1500m race. 
• Reese Robinson of Jesus College displaying remarkable skill in the Triple Jump event, earning a well-deserved bronze medal. 
• Niamh Bridson Hubbard from Magdalene College also securing a bronze medal in the 1500m event.
• Mary Adeniji of Newnham College impressed with a bronze medal in the Long Jump.

In addition to the medalists, several other Cambridge students reached the finals and narrowly missed out on podium finishes, underscoring the depth of talent within the university.

The weekend included six students who are part of Cambridge’s UCAPP programme, showcasing the university's commitment to nurturing exceptional athletic talent. 

The BUCS success followed another great triumph for Cambridge University Amateur Boxing Club (CUABC) in the 114th Amateur Boxing Varsity in March. The Amateur Boxing Varsity stands as the longest-running amateur boxing fixture in the world since its inception in 1897.

Cambridge's Varsity Squad, comprising 12 fighters, travelled to Oxford where victory for the CUABC boxers unfolded in front of a boisterous crowd of 750 Oxford supporters. The final score was 6-3 and included 3 early stoppages by technical knockout. 

Cambridge's victory further extended their lead in the overall score, with the tally now standing at 58-56 in Cambridge's favour, reflecting the close competition between the two universities.

Clinical trials have shown that COVID-19 vaccines are highly effective at reducing symptoms, hospitalisation and deaths caused by the virus, including for people with obesity. Previous studies have suggested that antibody levels may be lower in vaccinated people who have obesity and that they may remain at higher risk of severe disease than vaccinated people with normal weight. The reasons for this have, however, remained unclear.

This study, published in the journal Nature Medicine, shows that the ability of antibodies to neutralise the virus declines faster in vaccinated people who have obesity. The findings have important implications for vaccine prioritisation policies around the world.

During the pandemic, people with obesity were more likely to be hospitalised, require ventilators and to die from COVID-19. In this study, supported by the NIHR Bioresource and funded by UKRI, the researchers set out to investigate how far two of the most extensively used vaccines protect people with obesity compared to those with a normal weight, over time.

A team from the University of Edinburgh, led by Prof Sir Aziz Sheikh, looked at real-time data tracking the health of 3.5 million people in the Scottish population as part of the EAVE II study. They looked at hospitalisation and mortality from COVID-19 in adults who received two doses of COVID-19 vaccine (either Pfizer-BioNTech BNT162b2 mRNA or AstraZeneca ChAdOx1).

They found that people with severe obesity (a BMI greater than 40 kg/m2) had a 76% higher risk of severe COVID-19 outcomes, compared to those with a normal BMI. A modest increase in risk was also seen in people with obesity (30-39.9kg/m2), which affects a quarter of the UK population, and those who were underweight. ‘Break-through infections’ after the second vaccine dose also led to hospitalisation and death sooner (from 10 weeks) among people with severe obesity, and among people with obesity (after 15 weeks), than among individuals with normal weight (after 20 weeks).

Prof Sir Aziz Sheikh said: “Our findings demonstrate that protection gained through COVID-19 vaccination drops off faster for people with severe obesity than those with a normal body mass index. Using large-scale data assets such as the EAVE II Platform in Scotland have enabled us to generate important and timely insights that enable improvements to the delivery of COVID-19 vaccine schedules in a post-pandemic UK.”

The University of Cambridge team – jointly led by Dr James Thaventhiran, from the MRC Toxicology Unit and Prof Sadaf Farooqi from the Wellcome-MRC Institute of Metabolic Science – studied people with severe obesity attending the Obesity clinic at Addenbrooke’s Hospital in Cambridge, and compared the number and function of immune cells in their blood to those of people of normal weight.

They studied people six months after their second vaccine dose and then looked at the response to a third 'booster' vaccine dose over time. The Cambridge researchers found that six months after a second vaccine dose, people with severe obesity had similar levels of antibodies to the COVID-19 virus as those with a normal weight.

But the ability of those antibodies to work efficiently to fight against the virus (known as ‘neutralisation capacity’) was reduced in people with obesity. 55% of individuals with severe obesity were found to have unquantifiable or undetectable ‘neutralising capacity’ compared to 12% of people with normal BMI.

“This study further emphasises that obesity alters the vaccine response and also impacts on the risk of infection,” said Dr Agatha van der Klaauw from the Wellcome-MRC Institute of Metabolic Science and first author of the paper. “We urgently need to understand how to restore immune function and minimise these health risks.”

The researchers found that antibodies produced by people with severe obesity were less effective at neutralising the SARS-CoV-2 virus, potentially because the antibodies were not able to bind to the virus with the same strength.

When given a third (booster) dose of a COVID-19 vaccine, the ability of the antibodies to neutralise the virus was restored in both the normal weight and severely obese groups. But the researchers found that immunity again declined more rapidly in people with severe obesity, putting them at greater risk of infection with time.

Dr James Thaventhiran, a Group Leader from the MRC Toxicology Unit in Cambridge and co-lead author of the SCORPIO study said: “It is promising to see that booster vaccines restore the effectiveness of antibodies for people with severe obesity, but it is concerning that their levels decrease more quickly, after just 15 weeks. This shows that the vaccines work as well in people with obesity, but the protection doesn’t last as long.”

Prof Sadaf Farooqi from the Wellcome-MRC Institute of Metabolic Science and co-lead author of the SCORPIO study said: “More frequent booster doses are likely to be needed to maintain protection against COVID-19 in people with obesity. Because of the high prevalence of obesity across the globe, this poses a major challenge for health services”.

Reference

A A van der Klaauw et al., ‘Accelerated waning of the humoral response to COVID-19 vaccines in obesity’, Nature Medicine (2023). DOI: 10.1038/s41591-023-02343-2

International aid for pre-primary education has fallen further behind an agreed 10% spending target since the COVID-19 outbreak, according to new research.

The report, compiled by academics at the University of Cambridge for the global children’s charity, Theirworld, highlights “continued, chronic” underfunding of pre-primary education in many of the world’s poorest nations, after years of slow progress and pandemic-related cuts.

Early childhood education is widely understood to be essential to children’s successful cognitive and social development and to breaking cycles of poverty in poorer countries. In 2017, Cambridge research for Theirworld resulted in UNICEF formally recommending that 10% of education aid should be allocated to pre-primary education. Last year 147 United Nations member states signed a declaration agreeing to the target.

According to the new report’s findings, aid spending is falling far short of this goal and any progress towards the target ground to a halt following the COVID-19 outbreak. The most recent figures, from 2021, indicate that the proportion of education aid spent on pre-primary education internationally during the pandemic dropped by approximately (US)$19.7 million: from 1.2% to 1.1%.

The report identifies several reasons for the decline, notably spending cuts by the World Bank’s International Development Association, EU Institutions, and by the governments of wealthy nations, such as the UK.

Professor Pauline Rose, Director of the Research for Equitable Access and Learning (REAL) Centre at the University of Cambridge’s Faculty of Education said: “Hundreds of millions of children around the world are missing out on high-quality pre-primary education despite clear evidence that prioritising this will improve their life chances. The overall trend is very worrying.”

“Although some progress has been made towards the 10% target, it started from a very low base. Other education levels are still being prioritised amid a general decline in aid spending. International commitments to pre-primary education are good, but we need concrete action.”

The United Nations’ 2030 Sustainable Development Goals include the ambition to provide all children with proper childcare and pre-primary education. Over the past seven years, Theirworld and the REAL Centre have systematically monitored aid spending, tracking progress towards this goal.

The new report was compiled using the Organisation for Economic Co-operation and Development’s creditor report system, which gathers information about the aid contributions of both individual countries and international agencies such as UNICEF and the World Bank.

It shows that over the past two decades, the proportion of education aid spending that goes to pre-primary education has never exceeded 1.2%. Between 2020 and 2021, spending on the sector dropped from $209 million to $189.3 million: a decrease of 9.4%, compared with a 6.9% fall in education aid overall and a 0.9% decline in total aid spending. In 2021, aid spending on post-secondary education – the vast majority of which never leaves donor countries – was 27 times higher than that spent on pre-primary, despite widespread acknowledgement of the need to invest in the early years.

The report nevertheless also shows that the 10% target is attainable. UNICEF, which has consistently prioritised pre-primary education, spent 30% of its education aid budget on the sector in 2021. Italy increased spending from $2.6 million to $38 million. The majority of this was allocated to the ‘National Strategy on Human Resource Development’ which focuses on supporting the Jordanian government in strengthening its education system.  

The research shows that pre-primary aid is highly concentrated from a few donors, leaving early childhood development in poorer countries particularly vulnerable to sudden fluctuations in those donors’ spending.

Much of the pandemic-induced drop in spending, for instance, occurred because the World Bank cut its investment in pre-primary education from $122.8 million to $70.7 million. Other donors, such as Canada, EU Institutions, France, Norway and the UK, also reduced spending in this area. In 2021, eight of the top 35 education donors allocated no funds to pre-primary education at all.

The UK’s contribution was lacklustre for the world’s sixth largest economy, due in part to the Government’s controversial decision to reduce overall aid spending from the UN-recommend target of 0.7% of Gross National Income to 0.5%. Between 2020 and 2021, its education aid spending dropped from $703.67 million to $584.95 million. Aid to pre-primary was particularly badly hit, falling from an already low $5.6 million in 2020 to just $1.8 million in 2021, equivalent to a mere 0.3% of its reduced education aid budget.

The report also shows that pre-primary education spending tends to be focused on lower-middle income countries rather than the very poorest nations. In 2021, just 15% of aid in this area went to countries classified as “low income”, while 52.7% was allocated to lower-middle income countries.

As a result, some of the world’s least-advantaged children have little prospect of receiving pre-primary support. Eritrea and Sudan, for example, received no pre-primary education aid in 2021. In many other poorer countries – such as the Central African Republic, Chad, Niger and Syria – the amount of aid per primary school-aged child was less than $5.

Rose said the finding pointed to the need for a model of “progressive universalism”, where those most in need receive a greater proportion of aid spending. “The biggest gaps are in the poorest countries, and particularly among the very poorest and least advantaged,” she said. “Increasing spending on pre-primary alone will not be enough. We also have to make sure those in greatest need are prioritised.”

The full report will be available on the Theirworld website.

The new Fellows have been elected to the Academy in recognition of their exceptional contributions to the advancement of biomedical and health science, cutting-edge research discoveries and translating developments into benefits for patients and wider society.

They join a prestigious Fellowship of 1,400 esteemed researchers who are central to the Academy’s work. This includes providing career support to the next generation of researchers and contributing to the Academy’s influential policy work to improve health in the UK and globally.

Professor Dame Anne Johnson PMedSci, President of the Academy of Medical Sciences, said: “These new Fellows are pioneering biomedical research and driving life-saving improvements in healthcare. It’s a pleasure to recognise and celebrate their exceptional talent by welcoming them to the Fellowship.

“This year, we are celebrating our 25th anniversary. The Fellowship is our greatest asset, and their broad expertise and dynamic ability has shaped the Academy to become the influential, expert voice of health. As we look to the future, the collective wisdom our new Fellows bring will be pivotal in achieving our mission to create an open and progressive research sector to improve the health of people everywhere.”

The new Cambridge Fellows are:

Professor Charlotte Coles FMedSci

Professor of Breast Cancer Clinical Oncology, Department of Oncology, NIHR Research Professor and Director of Cancer Research UK RadNet Cambridge

Professor Coles leads practice-changing breast radiotherapy trials, has influenced international hypofractionation policy and is addressing global health, gender and equity challenges within the Lancet Breast Cancer Commission.

“It’s an honour to be elected as a new Fellow of the Academy of Medical Sciences. This is a result of research collaborations in Cambridge, the UK and internationally and I’d like to thank these wonderful colleagues, especially patient advocates,” said Coles.

“I hope to contribute to the Academy’s work to increase equity, diversity and inclusion within leadership roles, including lower- and middle-income countries, to enrich research and improve the culture in Medical Sciences.”

Professor Emanuele Di Angelantonio FMedSci

Professor of Clinical Epidemiology and Donor Health, Department of Public Health and Primary Care, and Head of Health Data Science Centre, Human Technopole (Milan)

Professor Di Angelantonio’s research has focused on addressing major clinical and public health priorities in cardiovascular disease (CVD) and transfusion medicine. His election recognises his many contributions both in helping resolve important controversies in CVD prevention strategies and in improving the safety and efficiency of blood donation.

“I am delighted and honoured to be elected to the Fellowship of the Academy of Medical Sciences, which I recognise is an outcome of the collaborations with many colleagues in UK and worldwide,” said Di Angelantonio.

“Research excellence across medical sciences and translation to health improvements has been at the centre of the Academy’s mission and I am very pleased to now be able to contribute to fulfilling this aim as a Fellow.”

Dr Rita Horvath FMedSci

Director of Research in Genetics of Rare Neurological Disorders in the Department of Clinical Neurosciences and Honorary Consultant in Neurology

Dr Horvath is an academic neurologist using genomics and biochemistry to diagnose rare, inherited neurological disorders, with a focus on mitochondrial diseases. Throughout her career she has combined fundamental experimental work with clinical studies. She pioneered the development and implementation of next generation sequencing in the diagnosis of rare neurogenetic diseases in the UK, leading to precision genetic approaches. She has established extensive international collaborations, having impact in Europe, but also for underserved groups in countries where such expertise is lacking.

“I am delighted and honoured to be elected to this Fellowship, which recognises the impact of my work. I would not have achieved it without the support of my excellent colleagues and research team, for which I give my sincere thanks,” said Horvath.

“As a Hungarian woman working in different countries before I arrived in the UK in 2007, I feel particularly proud of this award, which I recognise is an outcome of the open and fair research environment in Cambridge. This Fellowship enables me to further expand my research to develop effective treatments for patients with rare inherited neurological diseases.”

Professor Eric Miska FMedSci

Herchel Smith Chair of Molecular Genetics and Head of Department of Biochemistry, Affiliated Senior Group Leader at the Gurdon Institute, Associate Faculty at the Wellcome Sanger Institute and Fellow of St John’s College

Professor Miska is a molecular geneticist who has carried out pioneering work on RNA biology. His work led to fundamentally new insights into how small RNA molecules control our genes and protect organisms from selfish genes and viruses, and how RNA can carry heritable information across generations. Miska is Founder and Director of STORM Therapeutics Ltd, which creates novel therapies that inhibit RNA modifying enzymes for use in oncology and other diseases.

“Wonderful recognition of the work of an amazing team of researchers I have the pleasure to work with,” said Miska. “Most of our research has been done using the roundworm C. elegans. As Friedrich Nietzsche wrote in Thus Spoke Zarathustra: ‘You have evolved from worm to man, but much within you is still worm’.”

Professor Serena Nik-Zainal FMedSci

NIHR Research Professor, Professor of Genomic Medicine and Bioinformatics, Department of Medical Genetics and Early Cancer Institute, and Honorary Fellow of Murray Edwards College

Professor Nik-Zainal’s research is focused on investigating the vast number of mutations that occur in human DNA from birth, causing patterns called ‘mutational signatures’, and the associated physiological changes to cellular function, in progressive diseases such as cancer and neurodegeneration. She uses a combination of experimental and computational methods to understand biology and to develop clinical tests for early detection and precision diagnostics. Her team also builds computational tools to enable genomic advances become more accessible across the NHS. 

“What an honour it is to be elected to the Fellowship. This is a wonderful recognition of the work from my team,” said Nik-Zainal. “We are thrilled and hugely indebted to all our inspiring collaborators, supporters and patients, who have shared in our passion and joined us on our path, exploring biomedical science and translating insights into patient benefit.”

Professor Julian Rayner FMedSci

Director of the Cambridge Institute for Medical Research, School of Clinical Medicine, Honorary Faculty at the Wellcome Sanger Institute, and Director of Wellcome Connecting Science

Professor Rayner’s research has made significant contributions to our understanding of how malaria parasites recognise and invade human red blood cells to cause disease. His work has helped to identify new vaccine targets, such as a protein essential for red blood cell invasion that is now in early stage human vaccine testing, and inform antimalarial drug development, through co-leading the first ever genome-scale functional screens in malaria parasites. He collaborates closely with researchers in malaria-endemic countries and is strongly committed to engaging public audiences with the process and outcomes of science.

“Malaria is a devastating and too often forgotten disease that still kills more than half a million children every year. Tackling it requires deep collaboration and working across disciplines. I’m enormously honoured by this announcement, which reflects not my work but the work of all the talented people I’ve been lucky enough to host in my lab, and collaborations with friends and colleagues across the world,” said Rayner.

“I’m excited to become a Fellow of the Academy of Medical Sciences because I strongly share their conviction that science is not just for scientists. I believe that dialogue, learning and public engagement are all fundamental and essential parts of the research process, and I look forward to contributing to their leading role in these areas.”

Professor James Rowe FMedSci

Professor of Cognitive Neurology, Department of Clinical Neurosciences, and MRC Cognition and Brain Sciences Unit

Professor Rowe leads a highly interdisciplinary research team at the Cambridge Centre for Frontotemporal Dementia and at Dementias Platform UK to improve the diagnosis and treatment of people affected by dementia. His work integrates cognitive neuroscience, brain imaging, fluidic biomarkers, computational models and neuropathology for experimental medicine studies and clinical trials. He is motivated by his busy clinical practice and the need for better diversity and inclusivity throughout medical research.

“I am delighted and honoured to be elected to the Fellowship of the Academy of Medical Sciences. It is a testament to the many wonderful colleagues and students I have been fortunate to work with, and to inspirational mentors,” said Rowe.

“Research excellence, and translation of research for direct human benefit, comes from innovation and collaboration in diverse cross-disciplinary teams. I believe in the vision and values of the Academy as the route to better health for all.”

In addition, two researchers from the wider community have also been elected:

Dr Trevor Lawley FMedSci, Senior Group Leader, Wellcome Sanger Institute and Chief Scientific Officer, Microbiotica

Professor Ben Lehner FRS FMedSci, Senior Group Leader, Human Genetics Programme, Wellcome Sanger Institute

Fifteen fully-funded PhD studentships based in these collections, and with a strong community focus, will be offered, with the first five studentships beginning in October 2024.

The Collections and Communities in the East of England CDP consortium, the region’s first, will equip future research leaders with the skills and experience for careers in the creative and cultural sectors, supporting a pipeline of staff into the museum and cultural sector.

The Consortium holds extraordinary collections of over 20 million items, spanning the globe and hundreds of millions of years, including art and archaeology, anthropology, social history, natural history, books, archives, photography, born digital material, buildings and living plants.

In line with the priorities of the new University of Cambridge Strategic Research Initiative Collections-Connections-Communities, the PhD students will undertake research around today’s societal challenges, with a focus on health and wellbeing, environment and sustainability, and identity. 

Each student will benefit from a cross-consortium training programme, providing experience in both University and local authority museums, as well as professional internships in organisations including BT.  Consortium members will also ensure that students are equipped to undertake interdisciplinary research using participatory methodologies, where local communities play critical roles as co-researchers.  

This CDP will create an inspiring, diverse, transdisciplinary, inclusive and supportive environment for doctoral students that will shape the provision of doctoral training for the twenty-first century.  

Dr Neal Spencer, Principal Investigator of this award and the Fitzwilliam Museum's Deputy Director (Collections & Research) said: “Collections are ever more prominent in the debates around our history, present and future. We’re thrilled to be able to offer the next generation of researchers the opportunity to use these incredible collections to ask questions that will help shape our collective future.

“These PhD projects will engage our communities and employ a truly interdisciplinary approach. We look forward to welcoming the first students next year, who will benefit from the rich diversity of collections, institutions, expertise and training support provided by this partnership.”

The Arts and Humanities Research Council (AHRC) Collaborative Doctoral Partnership (CDP) offers up to 50 collaborative research studentships per annum to galleries, libraries, museums and archives, the creative industries, and public and third sector organisations. This new consortium will collaborate with CDP organisations across the UK.

Frank Hargrave, Colchester + Ipswich Museums manager, said: “Collections & Communities in the East of England offers the unrivalled opportunity to look at our collections differently, researching themes that are of particular relevance to our changing communities. To work with world-renowned academics on this research is an unrivalled opportunity and Colchester + Ipswich Museums are delighted with the funding announcement.”

Sarah Wilson, Heritage Manager at Peterborough Museum & Art Gallery, said: “Peterborough Museum and Art Gallery is delighted to be involved. The museum collections are hidden gems, a treasure trove for researchers that span 150 million years, cover a diverse range of subjects and offer endless opportunities for learning.”

Steve Miller, Director of Culture & Heritage, Norfolk County Council,  said: “Norfolk Museums Service is delighted to be a partner in the Collections & Communities in the East of England consortium. The initiative supports our commitment to building the skills and experience of a diverse workforce in the museums and cultural sector and we look forward to supporting the researchers to work with our local communities to gain important new insights into our collections.”

The researchers, from the University of Cambridge, harnessed the power of photosynthesis to convert CO2, water and sunlight into multicarbon fuels – ethanol and propanol – in a single step. These fuels have a high energy density and can be easily stored or transported.

Unlike fossil fuels, these solar fuels produce net zero carbon emissions and completely renewable, and unlike most bioethanol, they do not divert any agricultural land away from food production.

While the technology is still at laboratory scale, the researchers say their ‘artificial leaves’ are an important step in the transition away from a fossil fuel-based economy. The results are reported in the journal Nature Energy.

Bioethanol is touted as a cleaner alternative to petrol, since it is made from plants instead of fossil fuels. Most cars and trucks on the road today run on petrol containing up to 10% ethanol (E10 fuel). The United States is the world’s largest bioethanol producer: according to the U.S. Department of Agriculture, almost 45% of all corn grown in the US is used for ethanol production.

“Biofuels like ethanol are a controversial technology, not least because they take up agricultural land that could be used to grow food instead,” said Professor Erwin Reisner, who led the research.

For several years, Reisner’s research group, based in the Yusuf Hamied Department of Chemistry, has been developing sustainable, zero-carbon fuels inspired by photosynthesis – the process by which plants convert sunlight into food – using artificial leaves.

To date, these artificial leaves have only been able to make simple chemicals, such as syngas, a mixture of hydrogen and carbon monoxide that is used to produce fuels, pharmaceuticals, plastics and fertilisers. But to make the technology more practical, it would need to be able to produce more complex chemicals directly in a single solar-powered step.

Now, the artificial leaf can directly produce clean ethanol and propanol without the need for the intermediary step of producing syngas.

The researchers developed a copper and palladium-based catalyst. The catalyst was optimised in a way that allowed the artificial leaf to produce more complex chemicals, specifically the multicarbon alcohols ethanol and n-propanol. Both alcohols are high energy density fuels that can be easily transported and stored.

Other scientists have been able to produce similar chemicals using electrical power, but this is the first time that such complex chemicals have been produced with an artificial leaf using only the energy from the Sun.

“Shining sunlight on the artificial leaves and getting liquid fuel from carbon dioxide and water is an amazing bit of chemistry,” said Dr Motiar Rahaman, the paper’s first author. “Normally, when you try to convert CO2 into another chemical product using an artificial leaf device, you almost always get carbon monoxide or syngas, but here, we’ve been able to produce a practical liquid fuel just using the power of the Sun. It’s an exciting advance that opens up whole new avenues in our work.”

At present, the device is a proof of concept and shows only modest efficiency. The researchers are working to optimise the light absorbers so that they can better absorb sunlight and optimising the catalyst so it can convert more sunlight into fuel. Further work will also be required to make the device scalable so that it can produce large volumes of fuel.

“Even though there’s still work to be done, we’ve shown what these artificial leaves are capable of doing,” said Reisner. “It’s important to show that we can go beyond the simplest molecules and make things that are directly useful as we transition away from fossil fuels.”

The research was supported in part by the European Commission Marie Skłodowska-Curie Fellowship, the Cambridge Trust, and the Winton Programme for the Physics of Sustainability. Erwin Reisner is a Fellow and Motiar Rahaman is a Research Associate of St John’s College, Cambridge.

Reference:
Motiar Rahaman et al. ‘Solar-driven liquid multi-carbon fuel production using a standalone perovskite-BiVO4 artificial leaf.’ Nature Energy (2023). DOI: 10.1038/s41560-023-01262-3

It is regrettable that the national pay and conditions dispute has reached a point whereby a marking and assessment boycott has been called. Very sadly, and as things stand, it is likely to have a significant impact on students at Cambridge, and across the country.

This cohort of students have already been hit especially hard by the pandemic; now, many are facing the likelihood that the completion of their degrees and their graduation may be delayed. The boycott also means that some international students may not be able to apply for post-study graduate visas on completion of their course. No-one wants students to suffer further, and we are deeply sympathetic to the strength of feeling in our student body. For many, including staff, this is a stressful and anxious time.

We jointly want this dispute to be resolved as quickly as possible and for students to have their exams marked on time. Any dispute plainly requires negotiation. The ACAS negotiations on pay and working conditions were interrupted earlier this year. It is regrettable that these talks ultimately failed to resolve the dispute. We therefore call for negotiations between UCEA and UCU to restart to reach an agreed settlement. This needs to happen urgently, for the sake of our students, staff and members.

A new analysis of ancient faeces taken from two Jerusalem latrines dating back to the biblical Kingdom of Judah has uncovered traces of a single-celled microorganism Giardia duodenalis– a common cause of debilitating diarrhoea in humans.

A research team led by the University of Cambridge say it is the oldest example we have of this diarrhoea-causing parasite infecting humans anywhere on the planet. The study is published in the journal Parasitology.  

“The fact that these parasites were present in sediment from two Iron Age Jerusalem cesspits suggests that dysentery was endemic in the Kingdom of Judah,” said study lead author Dr Piers Mitchell from Cambridge’s Department of Archaeology.

“Dysentery is a term that describes intestinal infectious diseases caused by parasites and bacteria that trigger diarrhoea, abdominal cramps, fever and dehydration. It can be fatal, particularly for young children.”

“Dysentery is spread by faeces contaminating drinking water or food, and we suspected it could have been a big problem in early cities of the ancient Near East due to over-crowding, heat and flies, and limited water available in the summer,” said Mitchell.

The faecal samples came from the sediment underneath toilets found in two building complexes excavated to the south of the Old City, which date back to the 7th century BCE when Jerusalem was a capital of Judah.

During this time, Judah was a vassal state under the control of the Assyrian Empire, which at its height stretched from the Levant to the Persian Gulf, incorporating much of modern-day Iran and Iraq. Jerusalem would have been a flourishing political and religious hub estimated to have had between 8,000 and 25,000 residents.

Both toilets had carved stone seats almost identical in design: a shallow curved surface for sitting, with a large central hole for defecation and an adjacent hole at the front for male urination. “Toilets with cesspits from this time are relatively rare and were usually made only for the elite,” said Mitchell.

One was from a lavishly decorated estate at Armon ha-Natziv, surrounded by an ornamental garden. The site, excavated in 2019, probably dates from the days of King Manasseh, a client king for the Assyrians who ruled for fifty years in the mid-7th century.

The site of the other toilet, known as the House of Ahiel, was a domestic building made up of seven rooms, housing an upper-class family at the time. Date of construction is hard to pin down, with some placing it around the 8th century BCE.

However, its destruction is safely dated to 586 BCE, when Babylonian ruler Nebuchadnezzar II brutally sacked Jerusalem for a second time after its citizens refused to pay their agreed tribute, bringing to an end the Kingdom of Judah.

Ancient medical texts from Mesopotamia during the first and second millennium BCE describe diarrhoea affecting the populations of what is now the Near and Middle East. One example reads: “If a person eats bread and drinks beer and subsequently his stomach is colicky, he has cramps and has a flowing of the bowels, setu has gotten him”.

The cuneiform word often used in these texts to describe diarrhoea was sà si-sá. Some texts also included recommended incantations for reciting to increase the chances of recovery.

“These early written sources do not provide causes of diarrhoea, but they encourage us to apply modern techniques to investigate which pathogens might have been involved,” said Mitchell. “We know for sure that Giardia was one of those infections responsible.”

The team investigated the two-and-a-half-thousand year-old decomposed biblical period faeces by applying a bio-molecular technique called “ELISA”, in which antibodies bind onto the proteins uniquely produced by particular species of single-celled organisms.

“Unlike the eggs of other intestinal parasites, the protozoa that cause dysentery are fragile and extremely hard to detect in ancient samples through microscopes without using antibodies,” said co-author and Cambridge PhD candidate Tianyi Wang.

The researchers tested for Entamoeba, Giardia and Cryptosporidium: three parasitic microorganisms that are among the most common causes of diarrhoea in humans, and behind outbreaks of dysentery. Tests for Entamoeba and Cryptosporidium were negative, but those for Giardia were repeatedly positive.

Previous research has dated traces of the Entamoeba parasite, which also causes dysentery, as far back as Neolithic Greece over 4,000 years ago. Previous work has also shown that users of ancient Judean toilets were infected by other intestinal parasites including whipworm, tapeworm and pinworm.

This research was undertaken through a collaboration between the University of Cambridge, Tel Aviv University, and the Israel Antiquities Authority.

House-owners the world over consider ‘knocking through’ walls to achieve more open-plan living or changing layouts to accommodate new arrivals or circumstances. The results may be impressive, but they come at a sizeable financial and environmental cost. But what if it wasn’t necessary to demolish internal brick and/or plaster walls and build new ones?

Researchers at Cambridge’s Centre for Natural Material Innovation and partners PLP Architecture have just unveiled 'Ephemeral', an innovative alternative using engineered wood, at the London Design Biennale at London’s Somerset House (1st – 25th June 2023).

The project, led by Cambridge researcher Ana Gatóo, invites visitors to step into a home constructed around principles of affordability, sustainability, flexibility and adaptation. The flexible wooden partition walls – developed by Gatóo as part of her Cambridge PhD research – are made using kerfing, which allows wood to bend without breaking, the same technique employed in the construction of guitars and other stringed instruments.

The resulting wooden walls are simple, resilient, foldable and movable, meaning they can respond to the changing needs of residents, for instance, as children are born or leave the nest; as age or mobility bring changing requirements; or as homeworking patterns change.

Gatóo says: “Self-assembly and modular furniture have improved so many people’s lives. We’ve developed something similar but for walls so people can take total control of their interior spaces.”

“If you have lots of money, you can hire a designer and alter the interiors of your house, but if you don't, you're stuck with very rigid systems that could be decades out-of-date. You might be stuck with more rooms than you need, or too few. We want to empower people to make their spaces their own.”

The team’s ‘rooms of requirement’ provide elegant, affordable solutions which can be built into the fabric of the building from its first design, or seamlessly retrofitted – avoiding the mountains of carbon associated with demolition and reconstruction.

Gatóo says: “We’re using engineered timber, which is affordable and sustainable. It's a natural material which stores carbon, and when you don’t need it anymore, you can make something else with it. So you are creating minimal waste.”

Gatóo and her colleagues are based in the University’s Centre for Natural Material Innovation, a world leader in research into innovative and sustainable uses of timber in construction.

The team emphasises that their system could be used anywhere in the world, in workplaces as well as in homes, and the researchers have already had encouraging conversations with industry, including with affordable housing developers in India.

Gatóo says: “I’ve worked in development and post-disaster housing with NGOs in many countries around the world, always using sustainable materials. When I started my PhD, I wanted to merge making housing more affordable and social with technical innovation and sustainability. This is what our cities of the future need – caring for people and the environment at the same time.”

Implemented at scale, this innovation could change the construction industry for the better, empowering people to adapt their spaces to their needs while slashing housing costs and overcoming some of the hurdles which the construction industry must tackle to be part of a sustainable future.

Working with Cambridge Enterprise, the research team is seeking industry and policy partners to further advance product feasibility for industry-wide adoption.

The project is supported by PLP Architecture, The Laudes Foundation, the Future Observatory and the AHRC Design Accelerator.

Prof Ahmed, who has been Professor of Philosophy since 2022 and a Fellow of Gonville and Caius College since 2015, will take up his role later in the summer.

Dr Anthony Freeling, Acting Vice-Chancellor, University of Cambridge, said: "I congratulate Professor Ahmed on his appointment. Free speech, and fostering an environment of debate and discussion, are central to the role of all universities. We look forward to working with him."

Susan Lapworth, chief executive of the OfS, said: “Freedom of speech and academic freedom are essential underpinning principles of higher education in England.  Arif’s appointment will ensure they continue to be robustly defended across the sector.  Arif will bring an important academic perspective to the OfS’s work in this area and I am looking forward to working with him as we implement the new legislation.”
 
 

The researchers, from the University of Cambridge, programmed their robotic chef with a ‘cookbook’ of eight simple salad recipes. After watching a video of a human demonstrating one of the recipes, the robot was able to identify which recipe was being prepared and make it.

In addition, the videos helped the robot incrementally add to its cookbook. At the end of the experiment, the robot came up with a ninth recipe on its own. Their results, reported in the journal IEEE Access, demonstrate how video content can be a valuable and rich source of data for automated food production, and could enable easier and cheaper deployment of robot chefs.

Robotic chefs have been featured in science fiction for decades, but in reality, cooking is a challenging problem for a robot. Several commercial companies have built prototype robot chefs, although none of these are currently commercially available, and they lag well behind their human counterparts in terms of skill.

Human cooks can learn new recipes through observation, whether that’s watching another person cook or watching a video on YouTube, but programming a robot to make a range of dishes is costly and time-consuming.

“We wanted to see whether we could train a robot chef to learn in the same incremental way that humans can – by identifying the ingredients and how they go together in the dish,” said Grzegorz Sochacki from Cambridge’s Department of Engineering, the paper’s first author.

Sochacki, a PhD candidate in Professor Fumiya Iida’s Bio-Inspired Robotics Laboratory, and his colleagues devised eight simple salad recipes and filmed themselves making them. They then used a publicly available neural network to train their robot chef. The neural network had already been programmed to identify a range of different objects, including the fruits and vegetables used in the eight salad recipes (broccoli, carrot, apple, banana and orange).

Using computer vision techniques, the robot analysed each frame of video and was able to identify the different objects and features, such as a knife and the ingredients, as well as the human demonstrator’s arms, hands and face. Both the recipes and the videos were converted to vectors and the robot performed mathematical operations on the vectors to determine the similarity between a demonstration and a vector.

By correctly identifying the ingredients and the actions of the human chef, the robot could determine which of the recipes was being prepared. The robot could infer that if the human demonstrator was holding a knife in one hand and a carrot in the other, the carrot would then get chopped up.

Of the 16 videos it watched, the robot recognised the correct recipe 93% of the time, even though it only detected 83% of the human chef’s actions. The robot was also able to detect that slight variations in a recipe, such as making a double portion or normal human error, were variations and not a new recipe. The robot also correctly recognised the demonstration of a new, ninth salad, added it to its cookbook and made it.

“It’s amazing how much nuance the robot was able to detect,” said Sochacki. “These recipes aren’t complex – they’re essentially chopped fruits and vegetables, but it was really effective at recognising, for example, that two chopped apples and two chopped carrots is the same recipe as three chopped apples and three chopped carrots.”  

The videos used to train the robot chef are not like the food videos made by some social media influencers, which are full of fast cuts and visual effects, and quickly move back and forth between the person preparing the food and the dish they’re preparing. For example, the robot would struggle to identify a carrot if the human demonstrator had their hand wrapped around it – for the robot to identify the carrot, the human demonstrator had to hold up the carrot so that the robot could see the whole vegetable.

“Our robot isn’t interested in the sorts of food videos that go viral on social media – they’re simply too hard to follow,” said Sochacki. “But as these robot chefs get better and faster at identifying ingredients in food videos, they might be able to use sites like YouTube to learn a whole range of recipes.”

The research was supported in part by Beko plc and the Engineering and Physical Sciences Research Council (EPSRC), part of UK Research and Innovation (UKRI).

Reference:
Grzegorz Sochacki et al. ‘Recognition of Human Chef’s Intentions for Incremental Learning of Cookbook by Robotic Salad Chef.’ IEEE Access (2023). DOI: 10.1109/ACCESS.2023.3276234

One of the largest programmes in Webb’s first year of science is the JWST Advanced Deep Extragalactic Survey, or JADES, which will devote about 32 days of telescope time to uncover and characterise faint, distant galaxies. While data is still coming in, JADES has already discovered hundreds of galaxies that existed when the universe was less than 600 million years old. The international team, including researchers from the University of Cambridge, also has identified galaxies sparkling with a multitude of young, hot stars.

The extragalactic research group at the Cavendish Laboratory co-led by Professor Roberto Maiolino and Dr Sandro Tacchella is playing a leadership role in JADES, which is a partnership between the science team of NIRCam — JWST’s primary imager — and NIRSpec — JWST’s primary spectrograph.

In the autumn of 2022, JADES took deep imaging and spectroscopy in and around the iconic Hubble Ultra Deep Field. The JADES imaging is deep, extends further into the infrared, and covers a wider area than any previous imaging with the Hubble Space Telescope. Results based on this data, which have not yet been peer-reviewed, are being reported at the 242nd meeting of the American Astronomical Society in Albuquerque, New Mexico.

“With JADES, we want to answer a lot of questions, like: How did the earliest galaxies assemble themselves? How fast did they form stars? Why do some galaxies stop forming stars?” said Marcia Rieke of the University of Arizona, co-lead of the JADES programme.

For hundreds of millions of years after the big bang, the universe was filled with a gaseous fog. By one billion years after the big bang, the fog had cleared and the universe became transparent, a process known as reionisation. Scientists have debated whether active, supermassive black holes or galaxies full of hot, young stars were the primary cause of reionisation.

As part of the JADES programme, researchers studied these galaxies to look for signatures of star formation – and found them in abundance. “Almost every single galaxy that we are finding shows these unusually strong emission line signatures indicating intense recent star formation. These early galaxies were very good at creating hot, massive stars,” said Ryan Endsley from the University of Texas at Austin.

These bright, massive stars pumped out ultraviolet light, which transformed surrounding gas from opaque to transparent by ionising the atoms, removing electrons from their nuclei. Since these early galaxies had such a large population of hot, massive stars, they may have been the main driver of the reionisation process. The later reuniting of the electrons and nuclei produces distinctively strong emission lines.

The team also found evidence that these young galaxies underwent periods of rapid star formation interspersed with quiet periods where fewer stars formed. These fits and starts may have occurred as galaxies captured clumps of the gaseous raw materials needed to form stars. Alternatively, since massive stars quickly explode, they may have injected energy into the surrounding environment periodically, preventing gas from condensing to form new stars.

Another JADES result released today concerns the structural evolution of galaxies. The team used imaging and spectroscopy data to tackle a key unknown in extragalactic astrophysics, which is how the structural diversity of galaxies we observe today came to be.

The team discovered a galaxy in the infant universe – just 700 million years after the big bang – but with the structure of a far more mature galaxy. The galaxy is 100 times less massive than the Milky Way, but it is highly compact. Most of the young stars of this galaxy are in the outskirts, indicating that this galaxy is growing from the inside out.

“I was surprised to find such a compact galaxy this early in the universe,” said Tacchella, from Cambridge’s Cavendish Laboratory and Kavli Institute for Cosmology. “I’m excited that the telescope works so well, allowing us to do such detailed measurements of galaxies that are so distant.”

Another element of the JADES programme involves the search for the earliest galaxies that existed when the universe was less than 400 million years old. By studying these galaxies, astronomers can explore how star formation in the early years after the big bang was different from what is seen in current times.

The light from faraway galaxies is stretched to longer wavelengths and redder colours by the expansion of the universe – a phenomenon called redshift. By measuring a galaxy’s redshift, astronomers can learn how far away it is and, therefore, when it existed in the early universe. Before Webb, there were only a few dozen galaxies observed above a redshift of 8, when the universe was younger than 650 million years old, but JADES has now uncovered nearly a thousand of these extremely distant galaxies.

The gold standard for determining redshift involves looking at a galaxy’s spectrum, which measures its brightness at closely spaced wavelengths. But a good approximation can be determined by taking photos of a galaxy using filters that each cover a narrow band of colours to get a handful of brightness measurements. In this way, researchers can determine estimates for the distances of many thousands of galaxies at once.

Kevin Hainline of the University of Arizona in Tucson and his colleagues used Webb’s NIRCam (Near-Infrared Camera) instrument to obtain these measurements, called photometric redshifts, and identified more than 700 candidate galaxies that existed when the universe was between 370 million and 650 million years old. The sheer number of these galaxies was far beyond predictions from observations made before Webb’s launch. The observatory’s resolution and sensitivity are allowing astronomers to get a better view of these distant galaxies than ever before.

“Previously, the earliest galaxies we could see just looked like little smudges. And yet those smudges represent millions or even billions of stars at the beginning of the universe,” said Hainline. “Now, we can see that some of them are actually extended objects with visible structure. We can see groupings of stars being born only a few hundred million years after the beginning of time.”

“We’re finding star formation in the early universe is much more complicated than we thought,” said Rieke.

Adapted from a NASA press release.

The findings are from a qualitative study which investigated why more school leaders are not exploring alternative approaches to behaviour management. It argues that resource limitations and other concerns have left teachers feeling trapped within the prevailing system of mounting punishments. Under this, more than a thousand students are excluded, and almost 150,000 suspended, every year.

Educators interviewed for the study often acknowledged the potential benefits of alternative methods, but believed they had little choice but to follow the established orthodoxy. The most common reasons included cost, resource constraints, parental perception, and lack of time.

Most schools in England follow a “behaviourist” approach to student discipline, reinforcing positive behaviour and implementing escalating sanctions for repeated misconduct. Initially, students may receive a verbal warning for poor behaviour, followed by mid-level punishments like detention. Those who persist eventually face suspension and ultimately may be excluded from mainstream education.

The approach seems effective with many students, but there are concerns that it is still failing a significant minority. Government data have, for many years, consistently shown that persistent, disruptive behaviour is the main reason for suspensions or exclusions from school. The latest available figures suggest that about 1,500 students are excluded, and 148,000 suspended, each year for this reason.

The study was conducted by Dr Laura Oxley, now at the Faculty of Education, University of Cambridge, drawing on research she undertook while at the University of York. The newly-published element documents very in-depth interviews with a small group of 14 school leaders in England using a method called Interpretative Phenomenological Analysis. This was just part of the full study, which also surveyed 84 behaviour referral units in England and involved interviews with teachers in other education systems with different approaches to discipline.

Given the scale of the research, the findings should be interpreted cautiously. They do, however, highlight a possible cycle shaping behaviour management policy in England. Specifically, political and resource constraints limit schools’ capacity to experiment with alternative approaches, resulting in scarce evidence for their efficacy. This reinforces the view that the existing model is the only option.

Prior to her academic career Oxley worked with children who were at risk of exclusion from school, their families, and senior school leaders to support schools to provide appropriate educational provision for children who exhibited persistent misconduct. She held roles as an Exclusions and Reintegration Officer in East Yorkshire, and as an Education Inclusion Officer in Cambridgeshire.

“This is not a call to scrap the existing system, but to consider ways to enhance it,” she said. “For significant numbers of children, the current approach isn’t working.”

“Fundamentally, if a child persists with the same behaviour despite multiple punishments, it’s unlikely that they don’t comprehend the consequences. In those situations, instead of escalating the punishment, we should be asking why we aren’t trying something else? Unfortunately, even if school leaders have the motivation to try a different approach, they often feel that they have little choice. This means the same, standardised approach often prevails, even though it doesn’t suit every child.”

Widely-cited alternative behaviour management techniques include ‘restorative practice’ (RP) and ‘collaborative and proactive solutions’ (CPS). RP focuses on rebuilding positive relationships between students, or students and teachers, after breakdowns occur. CPS involves identifying the triggers behind persistent misbehaviour and addressing them collaboratively.

While neither method suits every situation, trials have yielded encouraging results. A 2019 study, for example, found that RP improved behaviour and reduced bullying. Although these approaches are already used by some schools in England, neither is currently used widely.

In Oxley’s study, school leaders identified cost, time and resource constraints as barriers to these alternatives, as they tend to be labour-intensive and require a thorough culture change. Most feared that they would place an intolerable extra burden on already overstretched staff. Issuing sanctions was seen as more efficient. Even providing space for private discussions with challenging students was sometimes considered unfeasible. One teacher explained: “We don’t have the staffing or capabilities for that”.

Some school leaders were concerned that teachers might perceive restorative approaches as a challenge to their authority in the classroom. There is evidence that training can change teachers' perspectives on handling challenging students, fostering a deeper understanding of the psychological context. Again, however, limited time and resources pose barriers to this, the study suggests.

Participants also expressed unease about parental reactions to alternative approaches. One school leader told Oxley: “A lot of pupils would tell you that it’s harder to do a restorative meeting than it is to miss your break time. It’s more difficult to get the message across to parents.” Some cited cases where heads had been “held to ransom” by parents demanding the exclusion of so-called “problem” pupils.

Oxley suggests these pressures have fostered a culture of risk aversion in schools, impeding potential reforms. “We need to give teachers and parents opportunities to understand the alternatives available,” she said. “The fact that researchers know methods like RP could work in situations where the current approach is not promoting behaviour change is irrelevant if teachers don’t share that confidence.”

The study highlights insufficient promotion of alternative methods in current Government guidance, which prioritises the sanctions-based approach. It emphasises, however, that providing adequate funding and time to enhance teachers’ and parents’ understanding of collaborative and restorative behaviour management techniques is essential to cultivating a “desire for change”.

“At the moment, alternative approaches are often dismissed as unrealistic,” Oxley said. “This stems from a lack of large-scale evidence due to limited opportunities to explore them in schools. Education researchers must address that by studying real experiences in schools, moving beyond limited trials. This will empower more school leaders to see restorative practice and other methods as valuable and viable, generating momentum for change.”

The findings are reported in the Psychology of Education Review.

The findings, published today in Nature Genetics, could help inform future treatments of type 2 diabetes, which affects around 4 million people in the UK and over 460 million people worldwide.

Several factors contribute to an increased risk of type 2 diabetes, such as older age, being overweight or having obesity, physical inactivity, and genetic predisposition. If untreated, type 2 diabetes can lead to complications, including eye and foot problems, nerve damage, and increased risk of heart attack and stroke.

A key player in the development of the condition is insulin, a hormone that regulates blood sugar – glucose – levels. People who have type 2 diabetes are unable to correctly regulate their glucose levels, either because they don’t secrete enough insulin when glucose levels increase, for example after eating a meal, or because their cells are less sensitive to insulin, a phenomenon known as ‘insulin resistance’.

Most studies to date of insulin resistance have focused on the fasting state – that is, several hours after a meal – when insulin is largely acting on the liver.  But we spend most of our time in the fed state, when insulin acts on our muscle and fat tissues.

It’s thought that the molecular mechanisms underlying insulin resistance after a so-called ‘glucose challenge’ – a sugary drink, or a meal, for example – play a key role in the development of type 2 diabetes. Yet these mechanisms are poorly-understood.

Professor Sir Stephen O’Rahilly, Co-Director of the Wellcome-MRC Institute of Metabolic Science at the University of Cambridge, said: “We know there are some people with specific rare genetic disorders in whom insulin works completely normally in the fasting state, where it’s acting mostly on the liver, but very poorly after a meal, when it’s acting mostly on muscle and fat. What has not been clear is whether this sort of problem occurs more commonly in the wider population, and whether it’s relevant to the risk of getting type 2 diabetes.” 

To examine these mechanisms, an international team of scientists used genetic data from 28 studies, encompassing more than 55,000 participants (none of whom had type 2 diabetes), to look for key genetic variants that influenced insulin levels measured two hours after a sugary drink.

The team identified new 10 loci – regions of the genome – associated with insulin resistance after the sugary drink. Eight of these regions were also shared with a higher risk of type 2 diabetes, highlighting their importance.

One of these newly-identified loci was located within the gene that codes for GLUT4, the critical protein responsible for taking up glucose from the blood into cells after eating. This locus was associated with a reduced amount of GLUT4 in muscle tissue.

To look for additional genes that may play a role in glucose regulation, the researchers turned to cell lines taken from mice to study specific genes in and around these loci. This led to the discovery of 14 genes that played a significant role in GLUT 4 trafficking and glucose uptake – with nine of these never previously linked to insulin regulation.

Further experiments showed that these genes influenced how much GLUT4 was found on the surface of the cells, likely by altering the ability of the protein to move from inside the cell to its surface. The less GLUT4 that makes its way to the surface of the cell, the poorer the cell’s ability to remove glucose from the blood.

Dr Alice Williamson, who carried out the work while a PhD student at the Wellcome-MRC Institute of Metabolic Science, said: “What’s exciting about this is that it shows how we can go from large scale genetic studies to understanding fundamental mechanisms of how our bodies work – and in particular how, when these mechanisms go wrong, they can lead to common diseases such as type 2 diabetes.”

Given that problems regulating blood glucose after a meal can be an early sign of increased type 2 diabetes risk, the researchers are hopeful that the discovery of the mechanisms involved could lead to new treatments in future.

Professor Claudia Langenberg, Director of the Precision Healthcare University Research Institute (PHURI) at Queen Mary University of London and Professor of Computational Medicine at the Berlin Institute of Health, Germany, said: “Our findings open up a potential new avenue for the development of treatments to stop the development of type 2 diabetes. It also shows how genetic studies of dynamic challenge tests can provide important insights that would otherwise remain hidden.”

The research was supported by Wellcome, the Medical Research Council and the National Institute for Health and Care Research.

Reference
Williamson, A et al. Genome-wide association study and functional characterisation identifies candidate genes for insulin-stimulated glucose uptake. Nat Gen; 8 June 2023; DOI: 10.1038/s41588-023-01408-9

Hever Castle curator, Alison Palmer, recognised the bejewelled, silver gilt binding of Trinity’s Book of Hours from the famous portrait of Thomas Cromwell painted by Hans Holbein the Younger in 1532-3, which hangs in the Frick Collection in New York. Palmer then worked with colleagues Kate McCaffrey and Dr Owen Emmerson to uncover the mystery of the book’s ownership.

The researchers followed a provenance trail that links the book from its donor, Dame Anne Sadleir, directly back to Thomas Cromwell. A team of experts have reviewed the new evidence and are confident that this is the very same book in the Holbein painting and that it belonged to Thomas Cromwell.

The Hardouyn Hours is thought to be the only object from any Tudor portrait to survive to this day.

The team established that the book, printed in Paris by Germain Hardouyn in 1527 or 1528, would have been among the books left by Cromwell to his secretary and protege Ralph Sadleir.

The book came to Trinity from Dame Anne Sadleir who married the grandson of Cromwell’s secretary. Anne was the daughter of the eminent lawyer Sir Edward Coke, a member of Trinity. She donated this Book of Hours, along with Trinity’s best-known manuscript – The Trinity Apocalypse – to the College in 1660.

Trinity’s Librarian Dr Nicolas Bell has collaborated with researchers at Cambridge and beyond to find out more about the Hardouyn Hours.

Based on a note in the front of the book, the gems on the covers and clasps were thought to be jaspers or jacinths, but analysis by Joanna Symonowicz, a doctoral researcher working with Dr Giuliana Di Martino in the University’s NanoPhotonics Centre, has used Raman spectroscopy to identify them as grossular garnets.

Michèle Bimbenet-Privat, formerly curator of metalwork at the Louvre in Paris, has confirmed that the silver gilt edging was made by Pierre Mangot, goldsmith to King Francis I of France. Mangot, who had moved to Paris the previous year from Blois, also made items for members of the Boleyn family. Mangot’s hallmark is the letter ‘M’ and a lower case ‘a’ tells us that the binding was made between December 1529 and 1530, in Paris, only a year or two after the book was printed.

The Holbein portrait celebrates Cromwell’s appointment as Master of the Jewel House which may explain why the Hardouyn Hours features so prominently.

Dr Nicolas Bell said: “This book of devotional prayers is remarkable for its unusually grand binding, covered with velvet, jewels and highly decorated silver gilt borders, all of which date from the time it was printed and illuminated. It has been enormously exciting to position this luxurious creation in the very centre of the court of Henry VIII, where we know that both Catherine of Aragon and Anne Boleyn owned copies of the very same edition.”

Kate McCaffrey, from Hever Castle, said: “We now believe that Anne Boleyn, Catherine of Aragon, and Thomas Cromwell all owned a copy of the same prayer book… We are confident that this discovery will shed new light on the often-troubled relationship between these giants of the Tudor court.”

Dr Tracy Borman said it was: “The most exciting Cromwell discovery in a generation – if not more.”

Hever Castle recently exhibited Catherine of Aragon’s 1527 prayer book (on loan from the Morgan Library in New York) alongside Anne Boleyn’s 1527 Book of Hours.

The Hardouyn Hours will be on loan to Hever Castle for their exhibition Catherine & Anne: Queens, Rivals, Mothers which runs until 10 November 2023. This is the first time that the book has ever been lent by Trinity College since it was received on 10th August 1660.

New research from the University of Cambridge and the University of Melbourne, published in Science Advances, shows neurotypical workers and students taking cognitive enhancers, or ‘smart’ drugs, may actually be inhibiting their performance and productivity.

Drugs such as methylphenidate, sold under the brand name Ritalin among others, are commonly prescribed for attention deficit hyperactivity disorder (ADHD), but are also taken by those without a diagnosis, in the belief that the drugs will enhance focus and cognitive performance.

In four double-blinded, randomised trials in Melbourne, each a week apart, the same 40 healthy participants took one of three popular ‘smart’ drugs (methylphenidate, modafinil or dextroamphetamine) or a placebo. They were assessed on how they performed in a test designed to model the complex decision-making and problem-solving present in our everyday lives.

While previous studies into the effects of smart drugs have used simpler cognitive tasks targeting memory or attention, the Melbourne trial involved more computationally complex activities that better simulate the difficult nature of tasks people encounter in daily life.

Participants were asked to complete an exercise known as the Knapsack Optimisation Problem – or ‘knapsack task’ – in which they were given a virtual knapsack with a set capacity, and a selection of items of different weights and values. The participants had to figure out how to best allocate items to the bag, to maximise the overall value of its contents.

Overall, participants taking the drugs saw small decreases in accuracy and efficiency, along with large increases in time and effort, relative to their results when not taking the drugs.

For example, when given methylphenidate – often used to treat ADHD in children, but increasingly taken by college students cramming for exams – participants took around 50% longer on average to complete the knapsack problem as when they were given a placebo.  

In addition, participants who performed at a higher level in the placebo condition compared to the rest of the group tended to show a bigger decrease in performance and productivity after receiving a drug.

In terms of “productivity”, for example – the level of progress per item moved in or out of the knapsack – the participants in the top 25% under a placebo regularly ended up in the bottom 25% under methylphenidate.

By contrast, participants who had a lower performance in a placebo condition only very occasionally exhibited a slight improvement after taking a drug.

Professor Peter Bossaerts, Leverhulme International Professor of Neuroeonomics at the University of Cambridge, believes more research needs to be conducted to find out what effects the drugs are having on users without ADHD.

“Our results suggest that these drugs don’t actually make you ‘smarter’,” said Bossaerts. “Because of the dopamine the drugs induce, we expected to see increased motivation, and they do motivate one to try harder. However, we discovered that this exertion caused more erratic thinking — in ways that we could make precise because the knapsack task had been widely studied in computer science.

“Performance did not generally increase, so questions remain about how the drugs are affecting people’s minds and their decision making.”

Dr Elizabeth Bowman researcher at the Centre for Brain, Mind and Markets at the University of Melbourne and lead author of the study said the results show we have yet to establish the effectiveness of pharmaceutical enhancers on our performance, when used by neurotypical people to perform everyday complex tasks.

“Our research shows drugs that are expected to improve cognitive performance in patients may actually be leading to healthy users working harder while producing a lower quality of work in a longer amount of time,” said Bowman.

A Cambridge University researcher has digitally reconstructed the missing soft tissue of an early human ancestor – or hominin – for the first time, revealing a capability to stand as erect as we do today.

Dr Ashleigh Wiseman has 3D-modelled the leg and pelvis muscles of the hominin Australopithecus afarensis using scans of ‘Lucy’: the famous fossil specimen discovered in Ethiopia in the mid-1970s.

Australopithecus afarensis was an early human species that lived in East Africa over three million years ago. Shorter than us, with an ape-like face and smaller brain, but able to walk on two legs, it adapted to both tree and savannah dwelling – helping the species survive for almost a million years.

Named for the Beatles classic ‘Lucy in the Sky with Diamonds’, Lucy is one of the most complete examples to be unearthed of any type of Australopithecus – with 40% of her skeleton recovered.

Wiseman was able to use recently published open source data on the Lucy fossil to create a digital model of the 3.2 million-year-old hominin’s lower body muscle structure. The study is published in the journal Royal Society Open Science.  

The research recreated 36 muscles in each leg, most of which were much larger in Lucy and occupied greater space in the legs compared to modern humans.

For example, major muscles in Lucy’s calves and thighs were over twice the size of those in modern humans, as we have a much higher fat to muscle ratio. Muscles made up 74% of the total mass in Lucy’s thigh, compared to just 50% in humans.

Paleoanthropologists agree that Lucy was bipedal, but disagree on how she walked. Some have argued that she moved in a crouching waddle, similar to chimpanzees – our common ancestor – when they walk on two legs. Others believe that her movement was closer to our own upright bipedalism.

Research in the last 20 years have seen a consensus begin to emerge for fully erect walking, and Wiseman’s work adds further weight to this. Lucy’s knee extensor muscles, and the leverage they would allow, confirm an ability to straighten the knee joints as much as a healthy person can today.

“Lucy’s ability to walk upright can only be known by reconstructing the path and space that a muscle occupies within the body,” said Wiseman, from Cambridge University’s McDonald Institute for Archaeological Research.

“We are now the only animal that can stand upright with straight knees. Lucy’s muscles suggest that she was as proficient at bipedalism as we are, while possibly also being at home in the trees. Lucy likely walked and moved in a way that we do not see in any living species today,” Wiseman said.

“Australopithecus afarensis would have roamed areas of open wooded grassland as well as more dense forests in East Africa around 3 to 4 million years ago. These reconstructions of Lucy’s muscles suggest that she would have been able to exploit both habitats effectively.”

Lucy was a young adult, who stood at just over one metre tall and probably weighed around 28kg. Lucy’s brain would have been roughly a third of the size of ours. 

To recreate the muscles of this hominin, Wiseman started with some living humans. Using MRI and CT scans of the muscle and bone structures of a modern woman and man, she was able to map the “muscle paths” and build a digital musculoskeletal model.

Wiseman then used existing virtual models of Lucy’s skeleton to 'rearticulate' the joints – that is, put the skeleton back together. This work defined the axis from which each joint was able to move and rotate, replicating how they moved during life.

Finally, muscles were layered on top, based on pathways from modern human muscle maps, as well as what little “muscle scarring” was discernible (the traces of muscle connection detectable on the fossilised bones). “Without open access science, this research would not have been possible,” said Wiseman.  

These reconstructions can now help scientists understand how this human ancestor walked. “Muscle reconstructions have already been used to gauge running speeds of a T-Rex, for example,” said Wiseman. “By applying similar techniques to ancestral humans, we want to reveal the spectrum of physical movement that propelled our evolution – including those capabilities we have lost.”

Reference:
Ashleigh L. A. Wiseman. 'Three-dimensional volumetric muscle reconstruction of the Australopithecus afarensis pelvis and limb, with estimations of limb leverage.' Royal Society Open Science (2023). DOI: 10.1098/rsos.230356