An international team of scientists have observed ripples in the fabric of spacetime called gravitational waves, arriving at the earth from a cataclysmic event in the distant universe. This confirms a major prediction of Albert Einstein’s 1915 general theory of relativity and opens an unprecedented new window onto the cosmos.

The gravitational waves were detected on 14 September 2015 at 09:51 UK time by both LIGO (Laser Interferometer Gravitational-wave Observatory) detectors in Louisiana and Washington State in the US. They originated from two black holes, each around 30 times the mass of the Sun and located more than 1.3 billion light years from Earth, coalescing to form a single, even more massive black hole.

The LIGO Observatories are funded by the National Science Foundation (NSF), and were conceived, built, and are operated by Caltech and MIT. The discovery, accepted for publication in the journal Physical Review Letters, was made by the LIGO Scientific Collaboration (which includes the GEO Collaboration and the Australian Consortium for Interferometric Gravitational Astronomy) and the Virgo Collaboration using data from the two LIGO detectors.

“The discovery of gravitational waves by the LIGO team is an incredible achievement,” said Professor Stephen Hawking, the Dennis Stanton Avery and Sally Tsui Wong-Avery Director of Research at the Department of Applied Mathematics and Theoretical Physics at the University of Cambridge. “It is the first observation of gravitational waves as predicted by Einstein and will allow us new insights into our universe. The gravitational waves were released from the collision of two black holes, the properties of which are consistent with predictions I made in Cambridge in the 1970s, such as the black hole area and uniqueness theorems. We can expect this observation to be the first of many as LIGO sensitivity increases, keeping us all busy with many further surprises.”

Gravitational waves carry unique information about the origins of our Universe and studying them is expected to provide important insights into the evolution of stars, supernovae, gamma-ray bursts, neutron stars and black holes. However, they interact very weakly with particles and require incredibly sensitive equipment to detect. British and German teams, including researchers from the University of Cambridge, working with US, Australian, Italian and French colleagues as part of the LIGO Scientific Collaboration and the Virgo Collaboration, are using a technique called laser interferometry.

Each LIGO site comprises two tubes, each four kilometres long, arranged in an L-shape. A laser is beamed down each tube to very precisely monitor the distance between mirrors at each end. According to Einstein’s theory, the distance between the mirrors will change by a tiny amount when a gravitational wave passes by the detector. A change in the lengths of the arms of close to 10^-19 metres (just one-ten-thousandth the diameter of a proton) can be detected.

According to general relativity, a pair of black holes orbiting around each other lose energy through the emission of gravitational waves, causing them to gradually approach each other over billions of years, and then much more quickly in the final minutes. During the final fraction of a second, the two black holes collide into each other at nearly one-half the speed of light and form a single more massive black hole, converting a portion of the combined black holes’ mass to energy, according to Einstein’s formula E=mc². This energy is emitted as a final strong burst of gravitational waves. It is these gravitational waves that LIGO has observed.

Independent and widely separated observatories are necessary to verify the direction of the event causing the gravitational waves, and also to determine that the signals come from space and are not from some other local phenomenon.

To ensure absolute accuracy, the consortium of nearly 1,000 scientists from 16 countries spent several months carefully checking and re-checking the data before submitting their findings for publication.

Christopher Moore, a PhD student from Cambridge’s Institute of Astronomy, was part of the discovery team who worked on the data analysis.

“Since September, we’ve known that something was detected, but it took months of checking to confirm that it was actually gravitational waves,” he said. “This team has been looking for evidence of gravitational waves for decades – a huge amount of work has gone into it, and I feel incredibly lucky to be part of the team. This discovery will change the way we do astronomy.”

Over coming years, the Advanced LIGO detectors will be ramped up to full power, increasing their sensitivity to gravitational waves, and in particular allowing more distant events to be measured. With the addition of further detectors, initially in Italy and later in other locations around the world, this first detection is surely just the beginning. UK scientists continue to contribute to the design and development of future generations of gravitational wave detectors.

The UK Minister for Universities and Science, Jo Johnson MP, said: “Einstein’s theories from over a century ago are still helping us to understand our universe. Now that we have the technological capability to test his theories with the LIGO detectors his scientific brilliance becomes all the more apparent. The Government is increasing support for international research collaborations, and these scientists from across the UK have played a vital part in this discovery.”

LIGO was originally proposed as a means of detecting these gravitational waves in the 1980s by Kip Thorne, Caltech’s Richard P. Feynman Professor of Theoretical Physics, Emeritus; Ronald Drever, professor of physics, emeritus also from Caltech; and Rainer Weiss, professor of physics, emeritus, from MIT.

“The description of this observation is beautifully described in the Einstein theory of General Relativity formulated 100 years ago and comprises the first test of the theory in strong gravitation. It would have been wonderful to watch Einstein’s face had we been able to tell him,” said Weiss.

“With this discovery, we humans are embarking on a marvelous new quest: the quest to explore the warped side of the universe—objects and phenomena that are made from warped spacetime. Colliding black holes and gravitational waves are our first beautiful examples,” said Thorne.

The discovery was made possible by the enhanced capabilities of Advanced LIGO, a major upgrade that increases the sensitivity of the instruments compared to the first generation LIGO detectors, enabling a large increase in the volume of the universe probed—and the discovery of gravitational waves during its first observation run.

The US National Science Foundation leads in financial support for Advanced LIGO. Funding organisations in Germany (Max Planck Society), the UK (Science and Technology Facilities Council, STFC) and Australia (Australian Research Council) also have made significant commitments to the project.

Several of the key technologies that made Advanced LIGO so much more sensitive have been developed and tested by the German UK GEO collaboration. Significant computer resources have been contributed by the AEI Hannover Atlas Cluster, the LIGO Laboratory, Syracuse University, and the University of Wisconsin-Milwaukee.

Several universities designed, built, and tested key components for Advanced LIGO: The Australian National University, the University of Adelaide, the University of Florida, Stanford University, Columbia University of New York, and Louisiana State University.

Cambridge has a long-standing involvement in the field of gravitational wave science, and specifically with the LIGO experiment. Until recently these efforts were spearheaded by Dr Jonathan Gair, who left last year for a post at the University of Edinburgh and who has made significant contributions to a wide range of gravitational wave and LIGO science; he is one of the authors on the new paper. Several scientists in Cambridge are current members of the collaboration, including PhD students Christopher Moore and Alvin Chua from the Institute of Astronomy; Professor Anthony Lasenby and PhD student Sonke Hee from the Cavendish Laboratory and the Kavli Institute of Cosmology; and Professor Mike Hobson from the Cavendish Laboratory.  

Further members of the collaboration until recently based at Cambridge, include Dr Philip Graff (author on the detection paper) and Dr Farhan Feroz, who, jointly with Mike Hobson and Anthony Lasenby, developed a machine learning method of analysis used currently within LIGO, as well as Dr Christopher Berry (author) and Dr Priscilla Canizares.

These findings will be discussed at next month's Cambridge Science Festival during the open afternoon at the Institute of Astronomy.  

Researchers have identified a drug that targets the first step in the toxic chain reaction leading to the death of brain cells, suggesting that treatments could be developed to protect against Alzheimer’s disease, in a similar way to how statins are able to reduce the risk of developing heart disease.

The drug, which is an approved anti-cancer treatment, has been shown to delay the onset of Alzheimer’s disease, both in a test tube and in nematode worms. It has previously been suggested that statin-like drugs – which are safe and can be taken widely by those at risk of developing disease – might be a prospect, but this is the first time that a potential ‘neurostatin’ has been reported.

When the drug was given to nematode worms genetically programmed to develop Alzheimer’s disease, it had no effect once symptoms had already appeared. But when the drug was given to the worms before any symptoms became apparent, no evidence of the condition appeared, raising the possibility that this drug, or other molecules like it, could be used to reduce the risk of developing Alzheimer’s disease. The results are reported in the journal Science Advances.

By analysing the way the drug, called bexarotene, works at the molecular level, the international team of researchers, from the University of Cambridge, Lund University and the University of Groningen, found that it stops the first step in the molecular cascade that leads to the death of brain cells. This step, called primary nucleation, occurs when naturally occurring proteins in the body fold into the wrong shape and stick together with other proteins, eventually forming thin filament-like structures called amyloid fibrils. This process also creates smaller clusters called oligomers, which are highly toxic to nerve cells and are thought to be responsible for brain damage in Alzheimer’s disease.

“The body has a variety of natural defences to protect itself against neurodegeneration, but as we age, these defences become progressively impaired and can get overwhelmed,” said Professor Michele Vendruscolo of Cambridge’s Department of Chemistry, the paper’s senior author. “By understanding how these natural defences work, we might be able to support them by designing drugs that behave in similar ways.”

For the past two decades, researchers have attempted to develop treatments for Alzheimer’s that could stop the aggregation and proliferation of oligomers. However, these attempts have all failed, in part because there was not a precise knowledge of the mechanics of the disease’s development: Vendruscolo and his colleagues have been working to understand exactly that.

Using a test developed by study co-author Professor Tuomas Knowles, also from the Department of Chemistry, and by Professor Sara Linse, from Lund University, the researchers were able to determine what happens during each stage of the disease’s development, and also what might happen if one of those stages was somehow switched off.

“In order to block protein aggregation, we need accurate understanding of exactly what is happening and when,” said Vendruscolo. “The test that we have developed not only measures the rates of the process as a whole, but also the rates of its specific component sub-processes, so that we can reduce the toxicity of the aggregates rather than simply stopping them forming.”

Johnny Habchi, the first author of the paper, and colleagues assembled a library of more than 10,000 small molecules which interact in some way with amyloid-beta, a molecule that plays a vital role in Alzheimer’s disease. Using the test developed by Knowles and Linse, the researchers first analysed molecules that were either drugs already approved for some other purpose, or drugs developed for Alzheimer’s disease or other similar conditions which had failed clinical trials.

The first successful molecule they identified was bexarotene, which is approved by the US Food and Drug Administration for the treatment of lymphoma. “One of the real steps forward was to take a molecule that we thought could be a potential drug and work out exactly what it does. In this case, what it does is suppress primary nucleation, which is the aim for any neurostatin-type molecule,” said Vendruscolo. “If you stop the process before aggregation has started, you can’t get proliferation.”

One of the key advances of the current work is that by understanding the mechanisms of how Alzheimer’s disease develops in the brain, the researchers were able to target bexarotene to the correct point in the process.

“Even if you have an effective molecule, if you target the wrong step in the process, you can actually make things worse by causing toxic protein assemblies to build up elsewhere,” said study co-author Professor Chris Dobson, Master of St John’s College, University of Cambridge. “It’s like traffic control – if you close a road to try to reduce jams, you can actually make the situation worse if you put the block in the wrong place. It is not necessarily the case that all the molecules in earlier drug trials were ineffective, but it may be that in some cases the timing of the delivery was wrong.”

Earlier studies of bexarotene had suggested that the drug could actually reverse Alzheimer’s symptoms by clearing amyloid-beta aggregates in the brain, which received a great deal of attention. However, the earlier results, which were later called into question, were based on a completely different mode of action – the clearance of aggregates – than the one reported in the current study. By exploiting their novel approach, which enables them to carry out highly quantitative analysis of the aggregation process, the researchers have now shown that compounds such as bexarotene could instead be developed as preventive drugs, because its primary action is to inhibit the crucial first step in the aggregation of amyloid-beta.

“We know that the accumulation of amyloid is a hallmark feature of Alzheimer’s and that drugs to halt this build-up could help protect nerve cells from damage and death,” said Dr Rosa Sancho, Head of Research at Alzheimer’s Research UK. “A recent clinical trial of bexarotene in people with Alzheimer’s was not successful, but this new work in worms suggests the drug may need to be given very early in the disease. We will now need to see whether this new preventative approach could halt the earliest biological events in Alzheimer’s and keep damage at bay in in further animal and human studies.”

Over the next 35 years, the number of people with Alzheimer’s disease is predicted to go from 40 million to 130 million, with 70% of those in middle or low-income countries. “The only way of realistically stopping this dramatic rise is through preventive measures: treating Alzheimer’s disease only after symptoms have already developed could overwhelm healthcare systems around the world.”

The body has a number of natural defences designed to keep proteins in check. But as we get older, these processes can become impaired and get overwhelmed, and some proteins can slip through the safety net, resulting in Alzheimer’s disease and other protein misfolding conditions. While neurostatins are not a cure for Alzheimer’s disease, the researchers say that they could reduce its risk by acting as a backup for the body’s natural defences against misfolding proteins.

“You wouldn’t give statins to someone who had just had a heart attack, and we doubt that giving a neurostatin to an Alzheimer’s patient who could no longer recognise a family member would be very helpful,” said Dobson. “But if it reduces the risk of the initial step in the process, then it has a serious prospect of being an effective preventive treatment.”

But is there hope for those already affected by the disease? The methods that have led to the present advance have enabled the researchers to identify compounds that, rather than preventing the disease, could slow down its progression even when symptoms have become evident. “The next target of our research is also to be able to treat victims of this dreadful disease,” said Vendruscolo.

Reference:
Johnny Habchi et. al. ‘An anti-cancer drug suppresses the primary nucleation reaction that produces the toxic Aβ42 aggregates linked with Alzheimer’s disease.’ Science Advances (2016). DOI: 10.1126/sciadv.1501244

When the numbers began to filter through from the spectrograph that was measuring small shifts in light from distant stars, Didier Queloz at first thought they were wrong. He certainly didn’t think he’d discovered an exoplanet. He checked and re-checked.

“At some point I realised the only explanation could be that the numbers were right.”

Today, many regard the discovery of 51 Pegasi b by Queloz and Professor Michel Mayor at the University of Geneva in 1995 as a moment in astronomy that forever changed the way we understand the universe and our place within it. It was the first confirmation of an exoplanet – a planet that orbits a star other than our Sun. Until then, although astronomers had speculated as to the existence of these distant worlds, no planet other than those in our own solar system had ever been found.

“For centuries, we only had the one single example of our own solar system on which to base our knowledge of planets,” says Queloz, who moved to Cambridge’s Department of Physics two years ago. “If you wanted to understand botany, you wouldn’t build the botanic picture from one single flower – you need all the others.”

Of the 1,900 or so confirmed exoplanets that have now been found – a tenth of these by Queloz himself – many are different to anything we ever imagined, challenging existing theories of planet formation.

Fifty light years from Earth, the exoplanet 51 Peg resembles the gas giant Jupiter. But unlike our distant cousin, which is located in the further reaches of our solar system and takes 10 years to orbit the Sun, 51 Peg ‘hugs’ its sun, orbiting every four days. It’s been hailed as an example of a whole new class of ‘roaster planets’ or ‘Hot Jupiters’ and has prompted scientists to wonder if large planets are able to migrate closer to their suns over millions of years.

“We are constantly surprised by the diversity of the other worlds,” says Queloz. Super-Earths like the volcanic planet 55 Cancri e with a temperature gradient across it of a thousand degrees; rogue planets like PSO J318.5-22, which roam freely between stars; Kepler-186f, which is lit by the light of a red star; and icy Kepler-16b with its double sunset. “For some, we don’t even have names to describe what they are.”

But, as yet, no planet has been discovered that could be considered a twin of our own. “We are finding planets of a similar size and mass to Earth but nothing at the right temperature – so-called Goldilocks planetary systems in the habitable zone close enough to the sun to be warmed by it but not so close that the presence of water and life is a sheer impossibility,” explains Queloz.

“Of course the question everyone would like to answer is whether there is life out there, because we are curious and we can’t resist – it’s how we are,” says Queloz.

Queloz believes that a new era of terra hunting is fast approaching. “The past 20 years has seen a ‘brute force’ hunt for exoplanets. We are now confident that they are practically everywhere you look for them. To find an Earth twin, however, we need to look at specific planets for longer.”

It’s not possible to see an exoplanet directly – it’s far too close to a blinding source of light, its star – so astronomers use two  techniques to look indirectly. Focusing on a star, they use NASA’s Kepler telescope to look for the dimming of starlight as the planet transits in front of it. From this, they calculate the planet’s size and temperature.

The breakthrough that Queloz and Mayor pioneered was a technique to look for signs of ‘wobble’ caused by the gravitational pull exerted by the planet on the star as it orbits. The technique needed to be accurate enough to detect a wobble of only 10 m/s –  the speed of a running man. To put this in context, the Earth moves at the speed of 30,000 m/s.”

Current technology works well for finding large exoplanets but to find planets the size of the Earth in the habitable zone astronomers need to look at smaller stars, and they need to overcome ‘stellar noise’, or natural variability in the data caused by physical motions of gas at the surface of the star.

“This noise is slowing further progress but we believe that it can be overcome by careful analysis and by extending the length of time we are able to observe a planet for,” adds Queloz. “Intensive runs on a small number of stars where an observation is carried out every night for years is far more valuable than unevenly spaced data taken over years.”

As techniques improve and with the launch of NASA's James Webb Space Telescope, astronomers will be able to ask whether what we understand as the basic molecules of life – carbon, oxygen and hydrogen – are present in the atmosphere of exoplanets, opening up the possibility of understanding their astrobiology and geophysics.

“My feeling is that life will be found, although life like us may be extremely rare because otherwise we probably would have seen it by now,” he adds. “It may take a long time, and many scientists, to find life, but maybe that’s part of the fun – it would be too easy otherwise!”

On the door of Queloz’s office is a spoof poster published by NASA in celebration of 20 years of exoplanet discoveries. Offering greetings from the Exoplanet Travel Bureau, it suggests 51 Pegasi b as a dream destination, or indeed “any planet you wish – as long as it’s far beyond our solar system.” Could this be reality one day? “It’s far too hard to say,” says Queloz. “But I would hope that sending a tiny probe of perhaps a few grams in weight might be possible in the next century.”

At one stage in recent years, Queloz was almost finding an exoplanet a week. His terra hunting has slowed while he focuses on improving the equipment and techniques that he believes will help find an Earth twin. But the excitement never goes away, he says. “I must admit that every time I find a planet I feel like a child – it’s a surprise because it’s a new system. I used to joke with people asking me about sci-fi – the reality is far more exciting and diverse than any sci-fi movie you can imagine!”

Inset images: top: Didier Queloz; bottom: 'travel' poster by NASA /JPL-Caltech

Other worlds: Professor Didier Queloz and Dr William Bains consider what life might be like under the light of other suns at the Cambridge Science Festival on 17 March 2016

The humble fruit fly is being put to an unusual use in sub-Saharan Africa: it’s being used as bait. Its intended lure? It’s hoped that the tiny creature, whose scientific name is Drosophila melanogaster, can stop the exodus of researchers from Africa.

At the moment most of the biomedical research being done in African laboratories is performed using rats. Now a project called DrosAfrica is underway to promote the use of the fruit fly as a model organism for research into human diseases.

There are several reasons for this. Firstly, rats are far more expensive to keep than fruit flies. As an affordable alternative, the fruit fly requires fewer resources to maintain and not as much expensive preparation for experiments.

Also, as a model system, Drosophila enables researchers to perform sophisticated genetics, live imaging, genome-wide analysis and other state-of-the-art approaches. Drosophila research has identified thousands of genes with human equivalents. This has provided key insights into cancer biology, pathology, neurobiology and immunology.

Drosophila is a prime model organism with tens of thousands of researchers working on every aspect of their biology. This work is aided by electronic open resources such as Flybase and stock centres like the one in Bloomington, Indiana in the US. The centre will send Drosophila to any lab in the world for the cost of shipping. These stock centres are funded by governmental grants enabling 100 000s flies to be kept alive in warehouses.

And entire research unit has been built with a focus on understanding a specific aspect of the fly. The most famous is called Janelia Farm, founded by the Howard Hughes Medical Institute in the US.

A bigger agenda

The project that’s using fruit flies as bait for scientists is known as DrosAfrica. It wants to drive the paradigm shift from rats to flies as experimental organisms. To do this, project leaders have organised workshops to share fruit fly techniques with universities and research institutes across sub Saharan Africa.

But there’s more to the work than merely extolling the virtues of fruit flies.

We also try to provide basic equipment such as dissecting microscopes, buffers, slides and antibodies for labelling proteins to facilitate the creation of local research communities. Such strong communities will ultimately be able to provide PhD programmes and research opportunities for African researchers. This will mean students don’t automatically feel they have to emigrate when seeking research opportunities.

Powerful local research programmes will also help to place the continent in the spotlight of international research. This could ultimately lead to a return of expatriates with a strong scientific background.

Activities organised by DrosAfrica: Past and Future

During the last three years, DrosAfrica has organised three workshops at the Institute of Biomedical Research Kampala International University-Western Campus, Uganda. Two focused exclusively on the use of Drosophila for biomedical research. The other concentrated on image and data analysis techniques.

The workshops' participants came from sub-Saharan Africa and included Nigerians, Kenyans, Ugandans and a delegate from South Sudan. They were able to work on several common projects and then networked after the workshops using information and resources on a dedicated website. These interactions planted the seed for developing an African Drosophila research community. At this institute, we’ve been lucky to build on the work that the non-profit organisation Trend has already done. Their team of volunteer scientists equipped the institute’s lab and introduced insect research models to the local scientists.

In 2016 the project plans to deliver workshops at Kenya’s International Centre of Insect Physiology and Ecology. The team is also visiting Nigeria during the second half of February to pave the way for future research collaborations.

The work done over the past few years has already paid dividends. Alumni from the workshops have presented their work at international scientific conferences and supervised undergraduate, Masters and PhD projects. PhD candidates have graduated on the basis of their research done on flies. One student has submitted an abstract to the American Society for Biochemistry and Molecular Biology.

DrosAfrica vision

The DrosAfrica project is taking important steps to increase the African contribution to scientific advancement. In the coming years we hope to further boost local research opportunities to promote genuine African research led by African researchers, all of them investigating matters of interest to Africans.

And to think: it all started with a tiny little fruit fly.

*DrosAfrica would like to acknowledge the generosity of Faculty members and sponsors, without whom the workshops described above wouldn’t have been possible. They are:

(Cambridge Africa, Sayansi, Wellcome Trust, TWAS, KIU, Pembroke College-Cambridge, St John’s College-Cambridge, Emmanuel College-Cambridge, EMBO, Fruit4Science, and very specially to FRS Tony Kouzarides).*

Silvia Muñoz-Descalzo, Lecturer in Biology & Biochemistry; Developmental Biology Theme, University of Bath and Timothy Weil, Lecturer, Department of Zoology, University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

Despite being written out of large parts of history, atheists thrived in the polytheistic societies of the ancient world – raising considerable doubts about whether humans really are “wired” for religion – a new study suggests.

The claim is the central proposition of a new book by Tim Whitmarsh, Professor of Greek Culture and a Fellow of St John’s College, University of Cambridge. In it, he suggests that atheism – which is typically seen as a modern phenomenon – was not just common in ancient Greece and pre-Christian Rome, but probably flourished more in those societies than in most civilisations since.

As a result, the study challenges two assumptions that prop up current debates between atheists and believers: Firstly, the idea that atheism is a modern point of view, and second, the idea of “religious universalism” – that humans are naturally predisposed, or “wired”, to believe in gods.

The book, entitledBattling The Gods, is being launched in Cambridge on Tuesday (February 16).

“We tend to see atheism as an idea that has only recently emerged in secular Western societies,” Whitmarsh said. “The rhetoric used to describe it is hyper-modern. In fact, early societies were far more capable than many since of containing atheism within the spectrum of what they considered normal.”

“Rather than making judgements based on scientific reason, these early atheists were making what seem to be universal objections about the paradoxical nature of religion – the fact that it asks you to accept things that aren’t intuitively there in your world. The fact that this was happening thousands of years ago suggests that forms of disbelief can exist in all cultures, and probably always have.”

The book argues that disbelief is actually “as old as the hills”. Early examples, such as the atheistic writings of Xenophanes of Colophon (c.570-475 BCE) are contemporary with Second Temple-era Judaism, and significantly predate Christianity and Islam. Even Plato, writing in the 4th Century BCE, said that contemporary non-believers were “not the first to have had this view about the gods.”

Because atheism’s ancient history has largely gone unwritten, however, Whitmarsh suggests that it is also absent from both sides of the current monotheist/atheist debate.  While atheists depict religion as something from an earlier, more primitive stage of human development, the idea of religious universalism is also built partly on the notion that early societies were religious by nature because to believe in god is an inherent, “default setting” for humans.

Neither perspective is true, Whitmarsh suggests: “Believers talk about atheism as if it’s a pathology of a particularly odd phase of modern Western culture that will pass, but if you ask someone to think hard, clearly people also thought this way in antiquity.”

His book surveys one thousand years of ancient history to prove the point, teasing out the various forms of disbelief expressed by philosophical movements, writers and public figures.

These were made possible in particular by the fundamental diversity of polytheistic Greek societies. Between 650 and 323 BCE, Greece had an estimated 1,200 separate city states, each with its own customs, traditions and governance. Religion expressed this variety, as a matter of private cults, village rituals and city festivals dedicated to numerous divine entities.

This meant that there was no such thing as religious orthodoxy. The closest the Greeks got to a unifying sacred text were Homer’s epics, which offered no coherent moral vision of the gods, and indeed often portrayed them as immoral. Similarly, there was no specialised clergy telling people how to live: “The idea of a priest telling you what to do was alien to the Greek world,” Whitmarsh said.

As a result, while some people viewed atheism as mistaken, it was rarely seen as morally wrong. In fact, it was usually tolerated as one of a number of viewpoints that people could adopt on the subject of the gods. Only occasionally was it actively legislated against, such as in Athens during the 5th Century BCE, when Socrates was executed for “not recognising the gods of the city.”

While atheism came in various shapes and sizes, Whitmarsh also argues that there were strong continuities across the generations. Ancient atheists struggled with fundamentals that many people still question today – such as how to deal with the problem of evil, and how to explain aspects of religion which seem implausible.

These themes extend from the work of early thinkers – like Anaximander and Anaximenes, who tried to explain why phenomena such as thunder and earthquakes actually had nothing to do with the gods – through to famous writers like Euripides, whose plays openly criticised divine causality. Perhaps the most famous group of atheists in the ancient world, the Epicureans, argued that there was no such thing as predestination and rejected the idea that the gods had any control over human life.

The age of ancient atheism ended, Whitmarsh suggests, because the polytheistic societies that generally tolerated it were replaced by monotheistic imperial forces that demanded an acceptance of one, “true” God. Rome’s adoption of Christianity in the 4th Century CE was, he says, “seismic”, because it used religious absolutism to hold the Empire together.

Most of the later Roman Empire’s ideological energy was expended fighting supposedly heretical beliefs – often other forms of Christianity. In a decree of 380, Emperor Theodosius I even drew a distinction between Catholics, and everyone else – whom he classed as dementes vesanosque (“demented lunatics”). Such rulings left no room for disbelief.

Whitmarsh stresses that his study is not designed to prove, or disprove, the truth of atheism itself. On the book’s first page, however, he adds: “I do, however, have a strong conviction – that has hardened in the course of researching and writing this book – that cultural and religious pluralism, and free debate, are indispensable to the good life.”

Battling The Gods is published by Faber and Faber. Tim Whitmarsh is A G Leventis Professor of Greek Culture and a Fellow of St John’s College, University of Cambridge.

Money might not buy you love, but according to some studies in psychology and consumer behaviour, how you spend it could reveal a thing or two about your romantic intentions. These studies demonstrate that just thinking about meeting a new partner can actually impact our shopping decisions in surprising ways – affecting men and women differently.

These studies are largely based on “costly signalling theory” – a model borrowed from evolutionary biology which suggests that conspicuous displays that are difficult to acquire, such as the elaborate and colourful nests of bowerbirds, serve a vital function in signalling one’s desirable traits.

In humans, the signals displayed by men and women tend to differ, due to the different traits that are thought to be attractive to the opposite sex based on evolutionary pressures. According to costly signalling theory, men should seek to display their wealth and resources to women, while women should advertise their helpfulness and kindness to men.

Emotional shopping

But how does this relate to spending? One study investigated this question by showing half of the participants pictures of attractive people of the opposite sex or having them reading a scenario about meeting an attractive person for a romantic walk on the beach. The other half read a neutral scenario unrelated to attraction. The results showed that men who had romance on their minds were more likely to report that they would spend money on conspicuous luxury goods, for example a new car, a new watch, a new cell phone or a nice holiday.

Women, on the other hand, did not increase their desire for luxury goods when thinking about meeting a new partner. However, such thoughts did increase their desire to be altruistic and helpful (this was determined by a question to both women and men about how much volunteer work they were willing to do if they had free time).

Another set of studies found that men were particularly interested in making luxury purchases after reading a scenario about a fleeting romance, rather than a potential long-term relationship. This was especially the case in men who were already more interested in short-term relationships than in long-term partnerships. Interestingly, women reported being more attracted to such conspicuously consuming men if they were looking for a short-term relationship, but not for the long term.

But what about women? One study found that women who were thinking about female romantic rivals trying to poach their mate were more likely to purchase luxury goods. This effect was not found when they did not imagine attractive rivals being around. However, the study did not examine to what extent men’s consumption can be linked to being scared about losing a partner.

Surprisingly, this study also found that women who possessed luxury goods were seen by other women as having a more devoted romantic partner.

Another study looked at how women’s spending habits would change during an economic recession. From a list of items, women chose more objects associated with grooming when thinking about a recession, as compared to no recession. However, non-grooming items such as headphones were more likely to be chosen when not thinking about a recession. Women also reported being more eager to attract a mate with resources (such as money) when thinking about a recession.

But how do we spend when we’re less optimistic about our romantic chances? A study by me and my colleagues has shown that men are willing to pay more for a conspicuous luxury car after thinking about a romantic rejection. This could be due to their desire to attract a new partner, after having had their self-esteem harmed. However, women show the opposite pattern: they are willing to pay more for a luxury car after thinking about a romantic success, likely because they view the car as a sign of relationship commitment with their partner.

Eric Levy, University Lecturer in Marketing (Assistant Professor), University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

Spinal cord injury is, in many respects, a testosterone disease, says Professor James Fawcett.

What he means by this is that four out of five spinal cord injuries happen to men, and the most common age group is early adulthood. “Men are not good at assessing risk at that age,” he says. “Females are much more sensible.”

It is perhaps not surprising, then, that when asked about their priorities, most quadriplegic people will select a return of sexual function as second after the use of arms and hands. Third on the list, above being able to walk, is a return of bladder and bowel control. “Way down the list is walking, because wheelchairs work reasonably well and patients can get used to using them,” says Fawcett, who heads the John van Geest Centre for Brain Repair at Cambridge.

Restoring bladder and bowel control is a particular challenge, however. Currently, patients have to fill their bladder with botulinum toxin (botox) to paralyse it and catheterise themselves several times a day. This may be the simplest method, but catheterisation can cause infection and scarring in the urethra. 

Instead, Fawcett is developing a device based on the ‘Brindley device’, named after physiologist Giles Brindley, who trained at Cambridge after the Second World War. The Brindley device is an implant to which an external stimulator is applied manually, causing the bladder to contract and empty itself. It has been used in thousands of patients, but it, too, is not without problems: it necessitates severing sensory nerves from the pelvis into the spinal cord, causing weakening of the pelvic muscles – and loss of sexual function. (For most male patients, Viagra can at least help them maintain an erection, but this is only half the problem. ‘Well OK, doc,’ they say, ‘you’ve given me an erection, but what’s the use if I can’t feel it?’”)

Fawcett and colleagues are developing a ‘biorobotic’ version of the Brindley device that can read signals from the sensory nerves in the pelvis, rather than requiring them to be cut. These signals would stop the bladder emptying itself at embarrassing times, tell the patient how full the bladder is, and allow them to use the electronics to empty it.

The ability to record signals from individual nerves has applications beyond just bladder control: Fawcett envisioned the technology as enabling patients who had lost a limb – such as soldiers losing arms or legs – to control robotic limbs. “The limbs themselves are quite sophisticated,” he says, “but what doesn’t work at all well is their interface with the nervous system.” The technology required for recording signals for a whole limb has proven to be extremely complicated, so the team is looking at the bladder-control device as a simpler demonstration of a proof of concept.

Biorobotics will be one focus of a proposed new Spinal Injury Research Centre to be based at Addenbrooke’s Hospital. Although still at the very early planning stages, the Centre will capitalise on Cambridge’s position as the regional trauma centre for the East of England (even though a lack of facilities means spinal injury patients have to be sent to Stoke Mandeville near Oxford for rehabilitation).

A simplified version of the adapted Brindley device has so far been trialled in around 50 dogs, in whom spinal cord injury is surprisingly common, particularly in dogs with longer spines, such as dachshunds. Many owners of injured dogs want to keep their pets but, as Fawcett explains, “the dogs are perfectly happy to paddle around with wheels under their back legs, but they do so dribbling urine around your house.”

In fact, a randomised controlled trial in 2013 showed that injured dogs may even be able to do away with their wheels. Professor Robin Franklin from the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute showed that transplanting cells found in the nasal cavity, known as olfactory ensheathing cells, into the injured spine could help restore movement to the previously paralysed limbs. Although the cell transplant did not restore bowel or bladder control, it was, says Franklin, “a landmark study” that offers the promise of translation into humans. Franklin’s colleague Dr Mark Kotter is currently seeking funding to carry out a trial in humans.

But as Fawcett says, the priority among injured patients is to recover use of their upper limbs. Spinal cord injury causes damage to motor nerve fibres travelling from the brain and to sensory nerve fibres travelling to the brain. Both are structurally different and need to be coaxed to regenerate across the site of the injury – but even getting the nerve fibres to span these couple of centimetres is a challenge.

“The problem is scar tissue,” says Fawcett. “It’s very difficult for nerve fibres to grow through this tissue.” He has identified an enzyme, chondroitinase, which can dissolve scar tissue. The enzyme works in rats and is in preclinical development for use in humans by the US biotech company Acorda Therapeutics.

Once the scar tissue has been dissolved, the nerve fibres need to regenerate and make new connections. Although restoring motor nerve fibres is proving a challenge, Fawcett has managed to restore sensory nerve fibres in rats, which is an important start. “Patients need to be able to feel what they’re doing and to sense pain. If they turn on a hot tap, they can easily scald themselves if they can’t feel the heat. And of course, they want sensation back in their genitalia.”

In most spinal cord injuries, some nerve fibres will always survive, and Fawcett believes we may be able to harness these to bypass nerve damage if we can harness a remarkable property of the young brain known as plasticity, which enables new connections to be made as we learn new skills. If a young child receives a spinal injury, their chances of recovery are much better than for an adult as their brain can adapt, but as we age, a cartilage-like coating wraps around nerve fibres, cementing the connections in place. These molecules make it difficult for the brain of an injured adult to find a way to bypass the injury.

“Interestingly,” explains Fawcett, “one of the main constituents of this cartilage is the same as that which blocks nerve growth in scar tissue – and we know we can dissolve this using chondroitinase. This should make rehabilitation – teaching the brain to do useful things again – dramatically more successful.”

Inset image: Credit The District.

Lesson learned: always check the microphones. Just after the start of the Hague trial of former Côte d'Ivoire president Laurent Gbagbo, prosecutor Eric MacDonald accidentally revealed the names of four anonymous prosecution witnesses within reach of a live microphone. The names were heard in the courtroom and the public gallery, and the recordings have been shared on social media.

The clearly disconcerted presiding judge, Cuno Tarfusser, wondered whether this incident “of utmost and inexcusable gravity” was due to “recklessness, superficiality or stupidity.” He did not wish to “speculate about something else”, alluding to hypothetical foul play. The judge formally apologised to the witnesses and ordered an internal investigation.

The incident highlights the difficult balancing act between holding transparent trials and prioritising witness and victim protection. And having observed the prosecutor’s opening statements from the public gallery, I saw the reactions of the two defendants' close supporters – reactions that revealed the deep fault lines in this case.

Gbagbo served as president of Côte d’Ivoire between 2000 and 2010. In 2010, he disputed the results of presidential elections that he officially lost, sparking a five-month political crisis that left more than 3,000 people dead. He is on trial with Charles Blé Goudé, the longtime leader of a youth movement known as Jeunes Patriotes (Young Patriots). Gbagbo appointed him minister for youth in 2010 during the crisis.

Gbagbo and Blé Goudé were transferred to the International Criminal Court in 2011 and 2014 respectively, and were charged as indirect co-perpetrators of crimes against humanity allegedly committed as part of a plan to keep Gbagbo in power “at any cost”. The two have both written tell-allbooks in which they refute such allegations.

I was at the ICC on the first day of the Gbagbo-Blé Goudé trial and waited with about 300 of their supporters outside the court’s shiny new permanent building in The Hague. One woman told me, only half-jokingly: “They built a new building just to try our president!” Protesting the portrait that was painted of Gbagbo as a dictator during the 2010-2011 crisis, another fan chanted sarcastically: “Give us back our dictator!”

Inside the court, diplomats, NGOs, journalists and members of Gbagbo and Blé Goudé’s close entourage filled the public gallery. Following the trial through headphones with simultaneous French and English translation, audience members have a clear view of the judges, prosecution and legal representative for victims teams on the left, both defence teams on the right, and both defendants sitting behind their respective representatives. For identity protection concerns, audience members cannot, however, see witnesses and victims testifying.

From inside the courtroom, one can look up and see members in the public gallery. After the second day’s hearings, Gbagbo stood up and saluted his supporters – who waved back ecstatically and left the gallery singing the Ivoirian anthem.

Disbelief, guffaws, and amulets

Since all the ICC’s criminal charges concern acts that took place in Abidjan, much of the evidence will be photo and video footage of the urban warfare that took place there. But rumours and conspiracy theories are rife in Côte d’Ivoire – and there are suspicions that evidence of this sort can be fabricated and altered.

Rumours have spread that video footage showing women lying on the ground, wounded from gunfire after an attack on a pro-Ouattara march in the Abobo neighbourhood of Abidjan, had been fabricated. When the prosecutor showed the graphic video in court, many of the pro-Gbagbo supporters reacted strongly, contesting its authenticity. For others, the dissonance between the gravity of the women’s injuries and the doubts of some supporters was jarring.

Another sticking point has been the relations between Ivoirian ethnic groups. As part of his case, the prosecutor wants to establish that Gbagbo and his “inner circle” encouraged crimes against perceived Ouattara supporters, who (very broadly) often share some combination of various characteristics: origins in northern Côte d’Ivoire and/or other West African countries, Muslim faith, and/or Dioula ethnicity.

The prosecution accused Blé Goudé of having ordered pro-Gbagbo youth to monitor “foreigners” and search for those who wore amulets known as “gris-gris”. At this, the Gbagbo supporters in the public gallery guffawed. To them, Ivoirians are not as ethnically divided as the prosecution contends – “gris-gris” are supposedly not worn exclusively by northerners and therefore couldn’t be a target sign for persecution.

The impression that foreign lawyers are trying Ivoirians without understanding the country’s nuances is a rallying point for those who contest the ICC’s legitimacy. But, ultimately, it is up to the judges to weigh this scepticism against well-documented evidence of persecution of pro-Ouattara supporters.

But who gets to determine whether or not a trial is political?

Problematic partiality

In her opening statement, the ICC prosecutor, Fatou Bensouda, proclaimed the trial apolitical, emphasising that it is not trying to determine either who won the elections or who should have won them. I immediately heard a chorus of incredulous groans from Gbagbo’s supporters. As they see it, this trial is the finale of a campaign that set out to oust Gbagbo as president with the help of France, a campaign waged first with hijacked elections and now with an instrumentalised ICC.

One of the most trenchant criticisms of the trial so far is that, by trying only the Gbagbo side without trying members of the Ouattara side (some of whom are suspected of serious crimes), the court is revealing its political nature. This line of criticism is what professor of law Darryl Robinson calls the “apologia” critique: the idea that by not trying members loyal to the incumbent Ouattara, the ICC is deferring to politics, thereby lacking the “principled independence” and “critical bite” that a court should have.

But the prosecutor’s strategy needs to be viewed in light of the ICC’s very particular nature. The Office of the Prosecutor requires co-operation from governments in order to bring a case to trial, and states' refusal to co-operate has led to cases being suspended before. At the crux of this trial’s inherent politicality is the tension between pursuing effective yet impartial prosecutions, bearing in mind all the conflict’s victims.

It is likely the trial will last several years. If so, the verdict will be handed down just in time for the run-up to Côte d'Ivoire’s next presidential elections in 2020 – when Gbagbo’s supporters can channel their reaction to the verdict into the political process.

Sophie Rosenberg, PhD Candidate in International Studies, University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

Charities will no longer be able to use public money for lobbying activities according to new rules. The anti-advocacy clause in government contracts announced by the Cabinet Office stated that “taxpayers’ money must be spent on improving people’s lives and spreading opportunities, not wasted on the farce of government lobbying government”, adding that it was “a zero sum game if Peter is robbed to pay Paul”.

There are structures for local communication between the public and voluntary sectors, such as Local Strategic Partnerships, but these do not connect charities with the national policymakers that regulate their work. This is particularly true for small and medium-sized charities who already lack channels of communication, despite the value of their experience working closely with service users. This is a potentially more profound political problem resulting from the clause.

So if the government is serious about not stifling debate, but rather to ensure money is spent on services, then it should demonstrate this through creating other venues for critiquing policy and transmitting knowledge gained from frontline service delivery.

Feedback from the frontline

The new clause has been criticised by umbrella charities such as the National Council for Voluntary Organisations (NCVO) and others, although charities such as Shelter, cited in the government announcement as an example of using private funds for lobbying, have been (officially) quiet. Those who have criticised the government’s regulation have expressed their concern that knowledge from frontline service delivery, which should inform better decision-making in policy, will go unused.

For these critics, the “farce” is a political construction that in practice undermines the aim of government funding to address social problems. John Tizard, an adviser and commentator on public policy, wrote that his “experience suggests that mature and confident politicians welcome informed debate and campaigns, even when they disagree with them”.

A joint letter from the Association of Chief Executives of Voluntary Organisations and NCVO also said the clause “may actually cost the taxpayer more money through limiting the range of insight that policy makers can draw upon”.

Deep cuts

Yet it’s the issue for smaller charities that cuts deepest. Both the local charities and government-funded consortia that bring together community-based associations working in the same area (such as public health), and the community activists the government now depends on to fill the gaps created by cuts, risk becoming more distant than ever from the political elites instigating those cuts. These groups operate job clubs, advice networks, food banks, lunch clubs, and other activities that are often replacing or compensating for reduced local public services.

Large charities such as Shelter, with diverse sources of funding, will continue to pressure the government over poverty-related issues like housing and likewise receive recognition as a representative of the sector. But smaller charities or government-funded local consortia, which already lack a voice because of their size and diversity, may find themselves even more financially and politically marginalised in a climate that will discourage open, public discussion.

This marginalisation may affect both local charities and policymakers in three specific ways:

• It will exacerbate the mounting frustration and workload among many local charities facing daily the personal consequences of policies like sanctions, the bedroom tax, and cuts to public services, but unable to leverage this responsibility for greater access to policymakers.

• Likewise, there will be an increasingly visible tension between local charities striving to be “safe spaces”, where service users can trust that someone will listen and try to help, and the policies that affect their work. Policies like the anti-advocacy clause implicitly convey a lack of trust in the intentions of charities and demonstrate the unwillingness of policymakers to listen to what charity staff have to say.

• Community-based associations that serve particular ethnic and religious groups may have little or no capacity to express the impact their projects have on integration, undermining policies aimed at inclusion.

Smaller charities (and bigger ones too) must be able to transmit knowledge and findings from the frontline to those making policy. If the government keeps the anti-advocacy clause, then it must provide alternative ways for charities to voice concerns – or share ideas. These forums should include charities dependent on government funding or which lack the resources to develop a policy position so that they have the opportunity to have genuine influence over policymaking. They should include a range of charities from diverse local communities, not just the large national charities that can afford to lobby using private funds, in order to gain the broadest understanding of the social impact of current policies and the policy reforms needed to improve this impact.

Shana Cohen, Senior Research Associate, University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

This is a significant increase in volume, but growth of the online alternative finance market is slowing down, with the annual growth in 2014/2015 being nearly half the 161% growth from 2013/14. Although the absolute year-on-year growth rate is slowing down, the report said, the alternative finance industry still recorded substantive expansion across almost all models.

The report also highlights the rapid expansion of donations-based crowdfunding, the perceived risk of fraud and malpractice by the industry, and increasing institutionalisation – as around a quarter of P2P (peer-to-peer) loans are now funded by institutional investors, including traditional banks and government through organisations such as the British Business Bank.

Pushing Boundaries - 2015 UK Alternative Finance is jointly published by the Cambridge Centre for Alternative Finance at the University of Cambridge and UK innovation foundation Nesta, in partnership with KPMG and with the support of CME Group Foundation. It is the latest in an annual series of reports from the University of Cambridge Judge Business School and Nesta, which track the size and development of online alternative finance, such as P2P lending and crowdfunding, in the UK.

Key findings of the report, a survey of 94 crowdfunding and P2P lending platforms, include:

• Increased share of the market for business finance: in 2015 it is estimated that online alternative finance platforms provided the equivalent of over 3% of all lending to SMEs (small and medium-sized enterprises) in the UK. For small businesses - those with a turnover of less than £1 million a year - P2P platforms provided an amount lending equivalent of 13% of all new bank loans.
• Institutionalisation is taking off: 2015 saw increased involvement from institutional investors in the online alternative finance market. The report shows that 32% of loans in P2P consumer lending and 26% of P2P business lending were funded by institutional investors.
• Donation-based crowdfunding is the fastest growing model: although starting from a relatively small base (£2 million), donation-based crowdfunding is the fastest growing model in the 2015 study, up by 500% to £12 million.
• Real estate is the single most popular sector: in 2014/2015 the most popular sector for online alternative finance investments and loans was real estate, with the combined debt and equity-based funding for this sector reaching £700m in 2015.
• The equity market is growing fast: the second fastest growing area of the alternative finance market is equity-based crowdfunding, up by 295% - from £84 million raised in 2014, to £332m in 2015. Excluding real estate crowdfunding, in 2014/2015 the equity-based crowdfunding sector contributed to £245 million worth of venture financing in 2015 – equivalent to over 15% of total UK seed and venture equity investment.
• The industry is generally satisfied with current regulation: when asked what they thought of existing regulation, more than 90% of P2P lending and equity-based crowdfunding platforms stated that they thought the current level was appropriate.
• The biggest risk to market growth is fraud or malpractice: when asked what they saw as the biggest risk to the future growth of the market, 57% of P2P lending and equity-based crowdfunding platforms cited the potential collapse of one or more of the well-known industry player due to fraud or malpractice.

“The substantive growth of alternative finance in the UK last year is not surprising, given that these new channels of finance are increasingly moving mainstream,” said Robert Wardrop, Executive Director of Cambridge Centre for Alternative Finance. “One of the key drivers underpinning this development is the growing institutionalisation of the sector. The Cambridge Centre for Alternative Finance is proud to shed light on this fascinating and dynamic industry, to help inform policymakers, regulators and the general public about how these areas of finance are increasingly becoming part of our everyday economic life.”

“2015 has seen another year of remarkable growth for Alternative Finance in the UK,” said Stian Westlake, Nesta’s Executive Director of Policy & Research. “Little more than a collection of plucky startups just six years ago, the sector now does £3.2 billion of business a year. As the sector grows and matures it is sure to face challenges - investors will be keen to see returns, and another financial crisis would certainly test the robustness of P2P lending.”

Warren Mead, Global co-lead of Fintech at KPMG, said: “After years of pushing boundaries, 2016 will be the year where ‘alternative’ financial options finally join the ranks of the mainstream. But while this evolution gives the industry the platform to grow, it also brings its own set of challenges. Being part of the financial establishment doesn’t sit well with its original social purpose. Incumbents are also playing catch up with their own digital investment, and are closing in on the disrupters’ lead. Meanwhile, platform failures within these growing networks are inevitable. So the question is, will the hard won enthusiasm for these platforms start to wane?”

The report was led by Bryan Zhang, a Director of the Cambridge Centre for Alternative Finance, and Peter Baeck, Principal Researcher at Nesta. It has been supported in part by funding from audit, tax and advisory service KPMG and CME Group Foundation, the foundation affiliated with CME Group.

Originally published on the Cambridge Judge Business School website. 

Restless, disordered, uncertain, impulsive, emotional – the teenage brain can be a confused fury of neural firings and misfirings.

For most 14- to 24-year-olds – the “risky age” as Professor Ed Bullmore describes it – the maelstrom eventually subsides. For some, episodes of depression, low self-esteem, self-harm or paranoia may intensify and become more frequent. For around 1 in 100, the change in mental state is so marked that it will become difficult for them to distinguish their delusions and hallucinations from reality – one of the hallmarks of schizophrenia.

“Schizophrenia is a particularly feared diagnosis,” says Bullmore. “People tend to think it means a chronic lifelong dependency on medication and therapy. It can mean this, but it can also last only a few years. The main thing that patients and their families want to know is what does the future hold – am I likely to be able to resume my life, get a job, and so on?”

Bullmore is co-chair of Cambridge Neuroscience, an initiative to enhance multidisciplinary research across the University, and leads the Department of Psychiatry, where he and colleagues have been developing imaging techniques that are revealing where and over what timescale abnormalities in the brain develop in people with mental health problems.

This is no easy task. Even being able to show a neural abnormality has been a major and relatively recent advance for understanding a condition that, Bullmore says, has in the past been regarded with prejudice and assumptions. “Demonstrating neural change moves us away from what might be regarded as a blaming approach where someone is made to feel personally responsible for the fact these symptoms exist. Imaging shows you that’s not the case – there is a biological basis.”

The task is made difficult because there is no single event or area of the brain that underlies schizophrenia. It has only been from the collation of results from imaging studies worldwide that it has become apparent that when it comes to mental health disorders the scientists need to look at the big picture – the changes happening in wiring circuits across the whole brain.

Imaging techniques such as magnetic resonance imaging (MRI) are helping to map the brain in unprecedented detail. Structural MRI follows the movement of water as it diffuses along the pathways forged by neurons – showing the network of connections spread across the brain. Functional MRI measures slow rhythmic activity in the brain; if two areas of the brain show activity at the same time the chances are they are functionally connected. Bullmore and colleagues have developed mathematical methods to calculate the probability of there being such a connection.

“Neuroscience is no longer just about neurons,” he explains. “We can also now talk in terms of hubs, networks and connectomes. If the brain is thought of as a computer, with ‘processors’ in the outer grey matter and ‘wires’ that connect them in the inner white matter, some hub regions are more highly connected than others.”

In schizophrenia, connectivity in the wiring diagram goes awry and highly connected hubs are especially affected – “you could call it a hubopathy,” says Bullmore. His team’s research has demonstrated that those who have suffered decades of schizophrenia have large-scale network abnormalities compared with a healthy brain, which goes some way to explaining the diversity and severity of symptoms experienced in schizophrenia. The question is: can imaging be used to chart this progression?

Bullmore and his colleagues believe so: “Roughly a third of patients recover, a third have intermittent symptoms and a third will be affected for decades by schizophrenia. At diagnosis we can’t currently tell which of these outcomes lies in store. But we think one day we will be able to correlate the pattern of network activity with future outcome.”

It’s not only what happens to patients post-diagnosis that interests Bullmore, but also what has happened neurologically in the years before diagnosis.

“For me, one of the most exciting aspects of psychiatry is that we can use imaging to study the ‘risky age’ of brain development to understand how the connectome grows or matures in healthy brains. We can then start to pinpoint which genetic and environmental factors might favour healthy adolescent brain network development and which factors might predispose to abnormal network development, leading to chronic disability or distress.”

In 2012, Bullmore and colleagues Professor Ian Goodyer and Professor Peter Jones in Cambridge’s Department of Psychiatry (in collaboration with Professor Ray Dolan and Professor Peter Fonagy from University College London) launched the NeuroScience in Psychiatry Network, funded by the Wellcome Trust. They have been recruiting a panel of 2,000 healthy volunteers aged 14–24 years, 300 of whom have had brain scans to contribute to one of the most comprehensive ‘circuit diagrams’ of the teenage brain ever attempted.

“Remarkably little is known about how brain networks grow during the crucial transition from childhood dependence to life as independent adults,” adds Bullmore. “The adolescent brain is still a bit of a black box. But it is a big step forward that we can now see healthy human brain development much more clearly, especially with the next-generation brain scanners coming to Cambridge soon [see panel]. It’s very exciting to think that we should then be able to understand and predict the pathways of brain network development that lead to schizophrenia.”

Hospitals’ £2bn deficit “certainly sounds dramatic”, they argue, “but hospitals don’t go bust – someone usually picks up the bill.” General practice doesn’t have that luxury, and its share of the NHS budget has fallen from 11% in 2006 to under 8.5% now.

Recent research shows that GPs are experiencing unprecedented levels of stress with increasing workload and overwhelming bureaucracy. A GP’s comment at a recent national conference encapsulates the sense of despair: “The pressure of work leaves me in constant fear of making mistakes”.

GPs are finding it harder to recruit trainees and to find partners to replace those increasingly retiring in their 50s.

Politicians and NHS leaders want more care to be moved into primary care, yet the share of funding devoted to general practice is falling as a high proportion of the NHS budget is channelled into hospitals, and in the past 10 years, the number of hospital consultants has increased at twice the rate of GPs.

GPs currently manage the great majority of patients without referral or admission to hospital but if this balance shifted only slightly, hospitals would be overwhelmed.

“It is general practice that makes the NHS one of the world’s most cost effective health services,” they say. The £136 cost per patient per year for unlimited general practice care is less than the cost of a single visit to a hospital outpatient department.

The authors, who are both internationally renowned experts in general practice, present a number of solutions. They say GPs need a “substantial injection of new funding” to provide more staff in primary care.

In addition, new roles are needed to take the “strain off” clinical staff, for example, physician associates, pharmacists, and advanced practice nurses. They also argue that reviews of practices’ contracts that threaten serious financial destabilisation should be put on hold while a fair funding formula is developed to replace the 25 year old ‘Carr-Hill’ formula.

NHS England should tackle spiralling indemnity costs by providing Crown Indemnity similar to that for hospital doctors, as GPs increasingly do work previously done by specialists.

Bureaucracy should be slashed, in part by changing the £224m Care Quality Commission inspection regime to one where only the 5-10% of practices found to be struggling are revisited within five years.

In hospitals, the ‘Choose and Book’ referral system needs radical reform – the authors estimate that communicating by phone, email, and online video link could reduce outpatient attendance by as much as 50% in some specialties. And the ‘Payment by Results’ system for funding hospitals must become a population based, capitated budget that incentivises hospitals to support patients and clinicians in the community.

The authors identify two ‘elephants in the room’ that can no longer be ignored. First, cuts to social care make it increasingly difficult for hospitals to discharge patients.

Second, the UK’s funding for healthcare has fallen well behind its European neighbours – now thirteenth out of 15 in healthcare expenditure as a percentage of gross domestic product. In 2000, Tony Blair promised to raise NHS spending to mid-European levels. Today, this would require another £22bn a year.

“Urgent action is needed to restore the NHS,” warn the authors. “But the crisis will not be averted by focusing on hospitals. If general practice fails, the whole NHS fails.”

Professor Martin Roland, Professor of Health Services Research at the University of Cambridge, adds: “GPs need to feel valued rather than continually criticised by politicians and regulators. Many other countries see primary care as the jewel in the crown of the NHS, yet many practices are at breaking point, with an increasing number simply handing in their contracts and closing.”

Sir Sam Everington, Tower Hamlets GP and chair of Tower Hamlets CCG, says: “Patients really value the support of their family doctor, particularly in crises like end of life care. Moving care into the community means supporting patients to die at home surrounded by their loved ones – this is one of many reasons why family medicine is critical to the NHS.

“Family medicine and new developments like social prescribing show the strengths of general practice in supporting vulnerable patients in all aspects of their physical and mental well-being.”

Reference
Martin Roland and Sam Everington. Tackling the crisis in general practice. The BMJ. 18 Feb 2016. dx.doi.org/10.1136/bmj.i942

Adapted from a press release by The BMJ.

Researchers have shown how a bizarrely shaped black hole could cause Einstein’s general theory of relativity, a foundation of modern physics, to break down. However, such an object could only exist in a universe with five or more dimensions.

The researchers, from the University of Cambridge and Queen Mary University of London, have successfully simulated a black hole shaped like a very thin ring, which gives rise to a series of ‘bulges’ connected by strings that become thinner over time. These strings eventually become so thin that they pinch off into a series of miniature black holes, similar to how a thin stream of water from a tap breaks up into droplets.

Ring-shaped black holes were ‘discovered’ by theoretical physicists in 2002, but this is the first time that their dynamics have been successfully simulated using supercomputers. Should this type of black hole form, it would lead to the appearance of a ‘naked singularity’, which would cause the equations behind general relativity to break down. The results are published in the journal Physical Review Letters.

General relativity underpins our current understanding of gravity: everything from the estimation of the age of the stars in the universe, to the GPS signals we rely on to help us navigate, is based on Einstein’s equations. In part, the theory tells us that matter warps its surrounding spacetime, and what we call gravity is the effect of that warp. In the 100 years since it was published, general relativity has passed every test that has been thrown at it, but one of its limitations is the existence of singularities.

A singularity is a point where gravity is so intense that space, time, and the laws of physics, break down. General relativity predicts that singularities exist at the centre of black holes, and that they are surrounded by an event horizon – the ‘point of no return’, where the gravitational pull becomes so strong that escape is impossible, meaning that they cannot be observed from the outside.

“As long as singularities stay hidden behind an event horizon, they do not cause trouble and general relativity holds - the ‘cosmic censorship conjecture’ says that this is always the case,” said study co-author Markus Kunesch, a PhD student at Cambridge’s Department of Applied Mathematics and Theoretical Physics (DAMTP). “As long as the cosmic censorship conjecture is valid, we can safely predict the future outside of black holes. Because ultimately, what we’re trying to do in physics is to predict the future given knowledge about the state of the universe now.”

But what if a singularity existed outside of an event horizon? If it did, not only would it be visible from the outside, but it would represent an object that has collapsed to an infinite density, a state which causes the laws of physics to break down. Theoretical physicists have hypothesised that such a thing, called a naked singularity, might exist in higher dimensions.

“If naked singularities exist, general relativity breaks down,” said co-author Saran Tunyasuvunakool, also a PhD student from DAMTP. “And if general relativity breaks down, it would throw everything upside down, because it would no longer have any predictive power – it could no longer be considered as a standalone theory to explain the universe.”

We think of the universe as existing in three dimensions, plus the fourth dimension of time, which together are referred to as spacetime. But, in branches of theoretical physics such as string theory, the universe could be made up of as many as 11 dimensions. Additional dimensions could be large and expansive, or they could be curled up, tiny, and hard to detect. Since humans can only directly perceive three dimensions, the existence of extra dimensions can only be inferred through very high energy experiments, such as those conducted at the Large Hadron Collider.

Einstein’s theory itself does not state how many dimensions there are in the universe, so theoretical physicists have been studying general relativity in higher dimensions to see if cosmic censorship still holds. The discovery of ring-shaped black holes in five dimensions led researchers to hypothesise that they could break up and give rise to a naked singularity.

What the Cambridge researchers, along with their co-author Pau Figueras from Queen Mary University of London, have found is that if the ring is thin enough, it can lead to the formation of naked singularities.

Using the COSMOS supercomputer, the researchers were able to perform a full simulation of Einstein’s complete theory in higher dimensions, allowing them to not only confirm that these ‘black rings’ are unstable, but to also identify their eventual fate. Most of the time, a black ring collapses back into a sphere, so that the singularity would stay contained within the event horizon. Only a very thin black ring becomes sufficiently unstable as to form bulges connected by thinner and thinner strings, eventually breaking off and forming a naked singularity. New simulation techniques and computer code were required to handle these extreme shapes.

“The better we get at simulating Einstein’s theory of gravity in higher dimensions, the easier it will be for us to help with advancing new computational techniques – we’re pushing the limits of what you can do on a computer when it comes to Einstein’s theory,” said Tunyasuvunakool. “But if cosmic censorship doesn’t hold in higher dimensions, then maybe we need to look at what’s so special about a four-dimensional universe that means it does hold.”

The cosmic censorship conjecture is widely expected to be true in our four-dimensional universe, but should it be disproved, an alternative way of explaining the universe would then need to be identified. One possibility is quantum gravity, which approximates Einstein’s equations far away from a singularity, but also provides a description of new physics close to the singularity.

The COSMOS supercomputer at the University of Cambridge is part of the Science and Technology Facilities Council (STFC) DiRAC HPC Facility.

Inset image: A video of a very thin black ring starting to break up into droplets. In this process a naked singularity is created and weak cosmic censorship is violated. Credit: Pau Figueras, Markus Kunesch, and Saran Tunyasuvunakool

Reference:
Pau Figueras, Markus Kunesch, and Saran Tunyasuvunakool ‘End Point of Black Ring Instabilities and the Weak Cosmic Censorship Conjecture.’ Physical Review Letters (2016). DOI: 10.1103/PhysRevLett.116.071102

Archaeologists working at Must Farm, a Bronze Age site near Peterborough, have uncovered a 3,000-year-old wheel, the first and largest complete example ever to be discovered in Britain.  

The find, which will broaden our understanding of Late Bronze Age life, is the latest from a settlement described as Peterborough’s Pompeii. The large wooden round houses, built on stilts, plunged into a river after a dramatic fire 3,000 years ago.

Thought to date from 1100-800 BC, the ancient wooden wheel is one metre in diameter and has been so well preserved by the silt that it still contains its hub. An incomplete Bronze Age wheel was found nearby at Flag Fen in the 1990s but the Must Farm find is unprecedented in terms of size and completeness.

The discovery poses challenges to what is known about the Late Bronze Age in terms of the technology available 3,000 years ago.

Duncan Wilson, Chief Executive of Historic England, said: “This remarkable but fragile wooden wheel is the earliest complete example ever found in Britain. The existence of this wheel expands our understanding of Late Bronze Age technology and the level of sophistication of the lives of people living on the edge of the Fens 3,000 years ago.”

The find is the latest in a series of discoveries at the Must Farm site which is providing an extraordinary insight into domestic life 3,000 years ago.  Excavation has already revealed circular wooden houses believed to be the best–preserved Bronze Age dwellings ever found in Britain.

The large wheel was unearthed just a few metres away from the biggest round house on the site. Other exciting finds include a wooden platter, small wooden box and rare small bowls and jars with food remains inside, as well as exceptional textiles and Bronze Age tools. After a catastrophic fire, the houses collapsed into a slow-moving and silty river, which preserved their contents in amazing detail.

David Gibson, Archaeological Manager at the Cambridge Archaeological Unit, Division of Archaeology, University of Cambridge, said: “The discovery of the wheel demonstrates that the inhabitants of this watery landscape had links to the dry land beyond the river.”

The Must Farm site is located at a quarry run by Forterra. Brian Chapman, Head of Land and Mineral Resources, said: “This is an incredible project which we are delighted to be part of. We understand that the discovery of the wheel is of national importance. We are committed to helping uncover the remaining secrets of this unique site at Must Farm and look forward to working with our partners over the coming months.”

Kasia Gdaniec, Senior Archaeologist for Cambridgeshire County Council, said: “Among the wealth of other fabulous artefacts and the new structural remains of round houses built over this river channel, this site continues to amaze and astonish us with its insight into prehistoric life, the latest being the discovery of this wooden wheel.  Believed to be the most complete example yet found from this period, this wheel poses a challenge to our understanding of both Late Bronze Age technological skill and, together with the eight boats recovered from the same river in 2011, transportation.”

Historic England (formerly known as English Heritage) and building products supplier Forterra are funding a major £1.1 million project to excavate 1,100 square metres of the Must Farm quarry site in Cambridgeshire. The Cambridge Archaeological Unit, Division of Archaeology, University of Cambridge is over half way through the excavation which is taking place because of concerns about the location and future preservation of the site.

The remains cannot be preserved indefinitely in situ and need to be recorded and analysed so that the unique site of Must Farm can expand our knowledge of the Bronze Age.  

Once the excavation is finished, the team will take the finds for further analysis and conservation. Eventually, the objects will be displayed at Peterborough Museum, Flag Fen and at other local venues. The end of the four-year project will see a major publication about Must Farm and an online resource detailing the finds.

The oldest Bronze Age wheel in Britain is the Flag Fen wheel which dates to c1300 BC but is incomplete and is smaller at 0.8m in diameter. Part of a Late Bronze Age wooden wheel is also known from Lingwood Fen near Cottenham in Cambridgeshire. In Europe, the earliest wheels date to at least 2,500 BC, in the Copper Age.

The Must Farm site is close to modern-day Whittlesey, Cambridgeshire, and sits astride a prehistoric watercourse inside the Flag Fen basin. The site has produced large quantities of Bronze Age metalwork, including a rapier and sword in 1969, and more recently the discovery of eight well-preserved log boats in 2011.

These finds place Must Farm alongside similar European Prehistoric Wetland sites: the ancient loch-side dwellings known as crannogs in Scotland and Ireland; stilt houses, also known as pile dwellings, around the Alpine Lakes; and the terps of Friesland, man-made hill dwellings in the Netherlands.

Adapted from a press release by Historic England.

Inset images: Excavation of Bronze Age Wheel at Must Farm one metre in diameter, with hub clearly visible (Copyright Cambridge Archaeological Unit, photo by Dave Webb).

Reed warblers are a little smaller than sparrows and each one weighs no more than a large envelope. As autumn begins they migrate some 5,000 km from Britain to West Africa, a journey they might make just two or three times in their short lives. In April they fly north to breed in the watery landscapes of northern Europe where they raise their young in nests suspended from reeds. Sometimes they are tricked into raising cuckoo chicks which grow to four times their size. 

In his book  Cuckoo - Cheating by Nature, Nick Davies (Department of Zoology) describes what it’s like to watch reed warblers at the Cambridgeshire nature reserve of Wicken Fen. He carefully parts the reeds until he can see a pair of warblers feeding their young in a nest. He senses the parents’ urgency in collecting insects for their chicks while keeping them warm and staying alert for signs of danger. When several hours later he stands up, the intimate world of the warbler disappears into the great expanse of fenland and the wide East Anglian skies.

Observation remains vital to learning more about the world, believes Davies. “There’s still plenty more to learn from going out into nature and watching carefully,” he says. “I get most of my ideas by watching animals and simply asking ‘I wonder why they’re doing that?’ The key to research is coming up with a good question and devising an experiment to answer it.”

Davies, who gives this week's Darwin Lecture (Games Animals Play), has been studying reed warblers at Wicken Fen for more than 30 years. He thinks of them as ‘his’ warblers and calls his interest in their lives, and their fragile niche within a changing environment, a kind of obsession. In the process of countless early mornings, and dozens of experiments, he and his colleagues have gradually unlocked some of the secrets of warblers’ interactions with cuckoos, who ‘parasitise’ other birds.

In an endless game of trickery and defence, the cuckoo and its hosts engage in an ‘arms race’ involving mimicry of many kinds – from the patterning of eggs to the demanding twittering of chicks – as the two species weigh up the risks of being duped and discovered. Reed warblers sometimes reject eggs that don’t look like their own – but what evidence does a warbler need before it takes such drastic action?  Recent research reveals that warblers eject suspect eggs from their nests only when local information is reinforced by signals from a wider ‘neighbourhood watch’.

Davies’s fascination for birds stems from a childhood spent on the Lancashire coast where the skies were full of skeins of pink-footed geese and the sand dunes were home to croaking natter jack toads. He got his taste for patient observation, for asking difficult questions (why, for example, does the reed warbler accept a cuckoo chick so obviously different to one of its own?), and interest in detective work from Niko Tinbergen, a pioneer of scientific studies of animal behaviour. As an evolutionary biologist, Davies is also respectful of the observational studies of the early naturalists who laid the foundations for subsequent experimental work.

The remarkable insights explored so vividly in Cuckoo - Cheating by Nature would have been impossible without research collaborations, often international. Birds migrate vast distances: to understand them, and how they’re shaped by evolution, requires an investigation of every aspect of their lives. Within the same species, there are behavioural variations which offer clues to their evolutionary pathways. To get a picture of the different ‘races’ of cuckoos (categorised by the species they parasitise to host their young) Davies has worked with biologists across the world.

He says: “Some of the most exciting discoveries are now being made in Africa by Claire Spottiswoode and in Australia by Naomi Langmore. In both places, the arms race between cuckoos and hosts has been going on much longer and has escalated to new levels. For example, in Australia some hosts reject chicks unlike their own and their cuckoo has combated this by evolving a mimetic chick. And in Africa, cuckoo hosts have the most remarkable egg signatures in the form of individual spots and squiggles which makes it easier for them to detect a foreign egg.”

In the accompanying podcast, Davies talks about the games animals play with particular reference to the dunnock, a small brown bird with a surprisingly inventive sex life.  

The lecture Games Animals Play will take place in the Lady Mitchell Hall, Sidgwick Site, University of Cambridge, on Friday, February 26, 2016 - 17:30 to 18:30. No booking required, no charge. Arrive in good time to secure a seat.

Main image: a reed warbler feeds a cuckoo fledgling (http://www.richardnicollphotography.co.uk/) Inset images: a clutch of reed warbler eggs with a larger cuckoo egg (Nick Davies); a meadow pipit feeds a cuckoo fledgling (Charles Tyler).

Sir Mark will take up office in September 2016, succeeding Professor Dame Jean Thomas, who has been Master of St Catharine’s since 2007.

Professor Sir Mark Welland is Professor of Nanotechnology and Head of Electrical Engineering at the University of Cambridge, where he has established the purpose-built Nanoscience Centre.

Sir Mark is currently researching into a broad range of both fundamental and applied problems. These include using nanotechnology to both understand and treat human diseases, biologically inspired nanomaterials for green technologies, and nanoelectronics for future generation energy transmission and sensing.

From April 2008 until May 2012, Sir Mark was Chief Scientific Adviser to the UK Government Ministry of Defence.

He was elected a Fellow of the Royal Society, a Fellow of the Royal Academy of Engineering, and a Fellow of the Institute of Physics in 2002, a Foreign Fellow of the National Academy of Sciences of India in 2008, and a Foreign Fellow of the Danish Academy of Sciences in 2010.

Sir Mark was awarded a Knighthood in the Queen's Birthday Honours list in 2011.

Sir Mark brings to the College unrivalled national and international experience and expertise, as well as a thorough understanding of the University and the way it can engage with the wider world.

Sir Mark said: "I am in equal measures humbled and excited at being elected as Master and am looking forward to supporting the Fellows, students and staff of St Catharine’s over the next years."

"I am honoured to be following Dame Jean, who has set a very high standard of leadership and intellectual rigour."

Dame Jean said: "The Fellows have elected a distinguished scientist as the 39th Master to lead the College in the next phase of its 543-year history. Sir Mark will find a welcoming and flourishing community at St Catharine’s. I offer him my warmest congratulations on his election, I wish him well for the future, and I hope he will be as happy at St Catharine’s as I have been for almost ten years."

Donald Trump has said Mexicans are “are bringing drugs, and bringing crime” to the US, while his fellow Republican presidential hopefuls are also talking up hawkish anti-immigration policies as the primary season unfolds.

That they feel confident doing so says something about American Latinos' surprising history of not showing up at the ballot box in big numbers. But based on the data we have, it seems the anti-immigration right may have finally gone too far.

Latinos are the largest ethnic minority group in the US, making up 17.4% of the population, yet the Latino electorate has so far underperformed at the ballot box. The Pew Research Centre projects that a record 27.3m Latinos will be eligible to vote in 2016. That’s 4m more than in 2012, but still only about half of the US’s Latino population.

Expanding the size of the electorate through voter registration and naturalisation campaigns is undoubtedly an important step towards augmenting the political influence of the Latino community. But the impact of a larger electorate will be mitigated if half of eligible Latino voters continue to stay home on election day.

At the 2012 election, an alarming 12m eligible Latinos chose not to vote, and the Latino turnout rate dropped from 49.9% in 2008 to 48%. Conversely, 66.6% of African Americans and 64.1% of non-Hispanic whites voted.

While mobilising unlikely voters in Chicago in 2014, I witnessed how misinformation and a lack of understanding of how the government functions fuels public disillusion with the political process, a major reason many voters, not just Latinos, opt to reject the ballot box.

But the viciously anti-immigrant rhetoric promulgated by Republican candidates is forcing Latino voters to pay attention.

Waking up

A 2015 survey of registered Latino voters jointly conducted by the National Council of La Raza (NCLR) and Latino Decisions found that 43% of respondents felt more interested in this year’s presidential election than in 2012. The same survey found that immigration reform, deportations and Barack Obama’s recent interventions via executive actions are the most important issues for 39% of respondents, tied with job creation and the economy – whereas immigration issues ranked only fourth among Latino voters' priorities in 2012.

This doesn’t make good reading for the Republican presidential front-runners, who claim to recognise the importance of the Latino vote to their campaigns but repeatedly alienate voters with their xenophobic rhetoric and unrealistic immigration policies.

On some themes, Donald Trump is in a league of his own: at the start of his campaign in the summer of 2015, he described Mexicans, by far the US’s largest Latino subgroup, as criminals and rapists. But allthreecandidates have called for mass deportations of undocumented immigrants and have promised to end Deferred Action for Childhood Arrivals (DACA), an administrative policy that allows certain undocumented youth the ability to temporarily live and work in the US.

These promises alarm me since I’m a DACA beneficiary. DACA, among other things, made it possible for me to gain employment after graduating from Amherst College and to continue my graduate education. I am currently a Gates Cambridge Scholar at the University of Cambridge, and a future Schwarzman Scholar at Tsinghua University in China.

If Trump, Cruz or Rubio reach the White House, the other 660,000 beneficiaries and I would return to living under fear of deportation without access to legal employment.

From the ground up

Deporting all 11m of us is not realistic and will hurt the economy. The cheap labour of undocumented workers subsidises the standard of living of every American. Undocumented immigrants also pay billions in taxes which help support public programs. The Institute on Taxation and Economy Policy that undocumented residents paid an estimated $11.84 billion in state and local taxes in 2012 – and that legalising undocumented people would add $2.2 billion a year to state and local taxes.

Republican candidates know their immigration proposals are unrealistic, but they chose to ignore the facts to score political points with their conservative base.

Fortunately, the American people are on our side. A 2015 Gallup poll found that 65% of US adults and 77% of Latinos favour a path to citizenship for undocumented immigrants. While I can’t vote, most of my extended family members, my colleagues and my friends can, and they will not vote for a candidate who wants to deport my mother and me.

Cruz and Rubio, both Cuban Americans, are perhaps hoping Latinos will ignore their stance on immigration and support them in the general election by virtue of their last names. But, if nominated, their ethnicity alone will not endear them to Latino voters. In the aforementioned NCLR survey, only 4% of respondents said they would blindly vote for a Latino candidate; 55% of Latinos listed the candidates’ positions as the most important factor influencing their vote.

This will only matter if Latinos vote in numbers that can make a real difference. Raised turnout and greater political representation are not the catalysts for political empowerment, but the products of it. If those who stand up for Latino interests want to sustain political participation in a meaningful way, civic engagement at the grassroots level must be their focus.

If they can be brought to the ballot box in representative numbers, they could dramatically change American politics. But without a sustained grassroots organising effort, a significant number of Latinos will remain political bystanders in the US.

Carlos Adolfo Gonzalez Sierra, ‎Gates Scholar in Latin American Studies, University of Cambridge

This article was originally published on The Conversation. Read the original article.

The opinions expressed in this article are those of the individual author(s) and do not represent the views of the University of Cambridge.

Public health guidelines state that children should accumulate at least an hour per day of moderate to vigorous intensity physical activity, which might include brisk walking or running, active participation in sports or exercising. At the same time, children should minimise the amount of time they spend sitting for extended periods.

To examine the seasonal variation in children’s behaviour, researchers at the Medical Research Council (MRC) Epidemiology Unit and Centre for Diet and Activity Research (CEDAR) at the University of Cambridge used data from the UK Millennium Cohort Study, which measured levels of physical activity in more than 700 seven year old children across a calendar year using accelerometers. Using the data, they also modelled the relationship between levels of activity and variables such as gender, weight and family income. The results of their study are published in the journal Medicine and Science in Exercise and Sport.

The researchers found that physical activity was lower in autumn and winter compared to spring; average activity levels across the group peaked in April at 65.3 min/day and reached their lowest levels in February at 47.8 min/day. Physical activity was at its lowest at weekends during winter. Children were at their most active during early summer, particularly at weekends.

The models suggested that boys’ activity levels changed more than girls’ throughout the year, but remained higher than girls’ at all times.  Although on average, boys achieved the recommended minimum activity even at winter, girls only tended to reach recommended levels during the summer.

“Physical activity is important for children’s health and development, but many do not get enough exercise,” says the study’s first author Dr Andrew Atkin, from the MRC Epidemiology Unit and CEDAR. “During spring and summer, when the weather is better and the days are longer, they tend to be playing out and more active, but during the darker, colder months, they are much less active.”

The team argues that the findings provide further support for initiatives aimed at encouraging physical activity amongst children during winter, particularly at the weekend. To some extent, the structure of the school day, including the need to travel to and from school, protects against inactivity during weekdays in term time.

“Children need to be given more opportunities to be active, particularly during the winter months and when the weather is bad,” adds Dr Esther van Sluijs, the study’s senior author also from CEDAR. “This might include better access to indoor spaces where children can be active or through schools changing their policies related to the use of indoor and outdoor spaces during bad weather.”

The study was largely supported by the UK Clinical Research Collaboration, whose funding comes from the British Heart Foundation, Department of Health, Economic and Social Research Council, Medical Research Council, and the Wellcome Trust. The Millennium Cohort Study was funded by the Economic and Social Research Council.

Reference
Atkin, AJ et al. Seasonal Variation in Children’s Physical Activity and Sedentary Time. Med. Sci. Sports Exerc., Vol. 48, No. 3, pp. 449–456, 2016. doi: 10.1249/MSS.0000000000000786

In 10 minutes, Srivas Chennu can work out what’s going on inside your head.

With the help of an electrode-studded hairnet wired up to a box that measures patterns of electrical activity, he can monitor the firing of millions of neurons deep within the brain. A few minutes later, wheeling his trolley-held device away, he has enough information to tell how conscious you really are.

What Chennu is looking for with his electroencephalogram (EEG) is the brain’s electrical ‘signature’. At any one moment in the body’s most complex organ, networks of neurons are firing up and creating ‘brain waves’ of electrical activity that can be detected through the scalp net.

This isn’t new technology – the first animal EEG was published a century ago – but computational neuroscientist Chennu has come up with a way of combining its output with a branch of maths called graph theory to measure the level of a person’s consciousness. What’s more, he’s developing the technology as a bedside device for doctors to diagnose patients suffering from consciousness disorders (such as a vegetative state caused by injury or stroke) to work out the best course of action and to support family counselling.

“Being conscious not only means being awake, but also being able to notice and experience,” he explains. “When someone is conscious, there are patterns of synchronised neural activity arcing across the brain that can be detected using EEG and quantified with our software.”

So for a healthy brain, the brain’s signature might look like a raging scrawl of lines sweeping back and forth, as integrated groups of neurons perceive, process, understand and sort information. When we sleep, this diminishes to a squiggle of the faintest strokes as we lose consciousness, flaring occasionally if we dream.

“Understanding how consciousness arises from neural interactions is an elusive and fascinating question. But for patients diagnosed as vegetative and minimally conscious, and their families, this is far more than just an academic question – it takes on a very real significance.

“The patient might be awake, but to what extent are they aware? Can they hear, see, feel? And if they are aware, does their level of awareness equate to their long-term prognosis?”

Chennu points to charts showing the brain signature of two vegetative patients. On one chart, just a few lines appear above the skull. In the other, the lines are so many they resemble, as Chennu describes, a multi-coloured mohican, almost indistinguishable from the signature one would see from a healthy person.

Did either of the patients wake up? “Yes, the second patient did, a year after this trace was taken. The point is, if you think that a patient will wake up, what would you do differently as a clinician, or as a family member?”

The research is based on the finding that a patient in a vegetative state could respond to yes or no questions, as measured by distinct patterns of brain activity using functional magnetic resonance imaging. It was discovered by Chennu’s colleagues in the Department of Clinical Neurosciences and the Medical Research Council Cognition and Brain Sciences Unit (MRC CBSU), led by Dr Adrian Owen.

In 2011, the group found the same attention to commands could be measured using EEG – a less expensive and more widely available technology. Three years later, Chennu and Dr Tristan Bekinschtein from the CBSU, and now in the Department of Psychology, showed that their mathematical analysis of the EEG outputs was enough to measure the ambient amount of connectivity in a patient’s brain.

Chennu hopes that the machine will fill a technology gap: “Misdiagnosis of true levels of consciousness in vegetative patients continues to be around 40% and depends on behavioural examination. In part this is because there is no gold standard for the assessment of a patient’s awareness at the bedside.”

With funding from the Evelyn Trust, he will assess and follow the treatment and rehabilitation trajectory of 50 patients over a three-year period. This will be the first time that a study has linked diagnosis, treatment and outcome to regular real-time assessment of the activity of a patient’s brain.

Meanwhile he is continuing to develop the medical device with industry as part of the National Institute for Health Research Healthcare Technology Co-operative for Brain Injury, which is hosted within the Department of Clinical Neurosciences.

“Medical advances mean that we are identifying subtypes of brain injury and moving away from ‘one size fits all’ to more-targeted treatment specific for an individual’s needs,” adds Chennu, who is also funded by the James S. McDonnell Foundation and works as part of a team led by Professors John Pickard and David Menon.

Intriguingly the device could even offer a channel of communication, as Chennu speculates: “The question that fascinates us is what type of consciousness do patients have? Perhaps we can create systems to translate neural activity into commands for simple communication – interfaces that could provide a basic but reliable communication channel from the ‘inbetween place’ in which some patients exist.

“Moreover, we think that the measurement of brain networks will provide clinically useful information that could help with therapeutics for a larger majority of patients, irrespective of whether they are able to demonstrate hidden consciousness.”

How conscious is my dog? Can robots become conscious? Are people in a vegetative state conscious? Don't miss Philosopher Professor Tim Crane and neuroscientist Dr Srivas Chennu at the Cambridge Science Festival, where they will look into our minds and wrestle with the meaning of what it is to be conscious. 'Brain, body and mind: new directions in the neuroscience and philosophy of consciousness', the Research Horizons Public Lecture, will be on Wednesday 16 March 2016, 8pm–9pm, Mill Lane Lecture Rooms, Mill Lane, Cambridge. Pre-booking required.